Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	TAU_HUMAN
Description:	microtubule-associated protein tau [Source:HGNC Symbol;Acc:6893]
Location:	chr17 q21.31
Node attribute:	substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S713	EIVYKsPVVSG		PhosphoSitePlus
S554	PPKSPsSAKSR		PhosphoSitePlus; RegPhos
S673	QSKIGsLDNIT	CAMK2A	HPRD
S315	VSGDTsPRHLS	CDK5	HPRD
S396	KKAKTsTRSSA	CDK5	RegPhos
T548	VAVVRtPPKSP	PKACa	RegPhos
S262	KSKIGsTENLK	CAMK2A	HPRD
T123	PPAPKtPPSSG	MAPK1	HPRD
S396	EIVYKsPVVSG	GSK3B	HPRD
T522	PGSPGtPGSRS	PKN1	RegPhos
S346	VSGDTsPRHLS	GSK3B	HPRD
S606	LSNVQsKCGSK	p38g	RegPhos
S411	NRPCLsPKHPT		PhosphoSitePlus
S575	LKNVKsKIGST	PKN1	HPRD; RegPhos
S262	KSKIGsTENLK	MARK1	HPRD
S713	EIVYKsPVVSG	GSK-3_beta	phosphoELM
S235	TSKCGsLGNIH	MARK1	HPRD
S519	YSSPGsPGTPG	Erk2	RegPhos; SysPTM
S388	KDGTGsDDKKA		PhosphoSitePlus
S342	KSPVVsGDTSP	GSK3B	HPRD
T217	TPSLPtPPTRE	CDK5	HPRD
S713	EIVYKsPVVSG	PDK1	RegPhos
S519	YSSPGsPGTPG	CDK_group	phosphoELM; RegPhos; SysPTM
T147	PGSPGtPGSRS	PRKACA	HPRD
S262	KSKIGsTENLK	PHKG1	HPRD
S525	PGTPGsRSRTP	GSK3B	HPRD; RegPhos
S516	RSGYSsPGSPG		PhosphoSitePlus
T534	TPSLPtPPTRE	PDK1	RegPhos
S247	VPGGGsVQIVY	MARK1	HPRD
T522	PGSPGtPGSRS	p38g	RegPhos
S183	PSSAKsRLQTA		HPRD
T77	KSKDGtGSDDK		HPRD
S356	QSKIGsLDNIT	PRKACA	HPRD
S733	VSSTGsIDMVD	TTBK1	RegPhos
S198	DRSGYsSPGSP	GSK3B	HPRD
S527	TPGSRsRTPSL		HPRD; RegPhos
T147	PGSPGtPGSRS	PKN1	HPRD
S519	YSSPGsPGTPG	p38g	RegPhos; SysPTM
S199	RSGYSsPGSPG	GSK3B	HPRD
T147	PGSPGtPGSRS	GSK3B	HPRD
S673	QSKIGsLDNIT	MARK1	HPRD; RegPhos
S713	EIVYKsPVVSG	CDK_group	phosphoELM; RegPhos
S579	KSKIGsTENLK	PKACa	RegPhos
T181	PPAPKtPPSSG	MAPK12	HPRD
T636	DLSKVtSKCGS	Tubulin-binding	PhosphoSitePlus
S579	KSKIGsTENLK	PKCd	RegPhos
T111	AGIGDtPSLED		RegPhos
T403	VVSGDtSPRHL		HPRD
T470	KTKIAtPRGAA	CDC2	RegPhos
S131	RMVSKsKDGTG		HPRD
S512	KSGDRsGYSSP	PKACa	RegPhos
S721	VSGDTsPRHLS	PDK1	RegPhos
S575	LKNVKsKIGST	GSK3B(GSK3 beta	RegPhos
T173	RQPSGtGPEDT	p38g	RegPhos
S515	DRSGYsSPGSP		PhosphoSitePlus
S515	DRSGYsSPGSP	PRKACA	HPRD
S235	QDSPPsKASPA	GSK3A	RegPhos
S241	PSSAKsRLQTA		HPRD
S637	LSKVTsKCGSL	MAPK12	HPRD
T492	RIPAKtPPAPK	PDK1	RegPhos
S721	VSGDTsPRHLS	GSK-3_beta	phosphoELM
S554	PPKSPsSAKSR	PHKg1	RegPhos
S396	KKAKTsTRSSA	GSK3B	RegPhos
S451	TSRTGsSGAKE		PhosphoSitePlus
T548	VAVVRtPPKSP	CDK_group	phosphoELM; RegPhos
S258	LKNVKsKIGST	PKN1	HPRD
T548	VAVVRtPPKSP	GSK-3_beta	phosphoELM
T159	TPSLPtPPTRE	CDK5	HPRD
S324	TSKCGsLGNIH	GSK3A	HPRD
S294	KDRVQsKIGSL	PKN1	HPRD
S198	DRSGYsSPGSP	PRKACA	HPRD
T263	SKIGStENLKH		HPRD
S552	RTPPKsPSSAK		PhosphoSitePlus; phosphoELM
T123	AAGHVtQEPES	Erk2	RegPhos
S262	KSKIGsTENLK	PRKCD	HPRD
T173	RQPSGtGPEDT		PhosphoSitePlus
S516	RSGYSsPGSPG	GSK3B	HPRD; RegPhos
S327	VSSTGsIDMVD		HPRD
S726	SPRHLsNVSST	PKACa	RegPhos
S307	EIVYKsPVVSG	GSK3B	HPRD
S422	IDMVDsPQLAT	CDK5	HPRD
S554	PPKSPsSAKSR	PHKG1	HPRD
S575	LKNVKsKIGST	GSK-3_beta	phosphoELM
S721	VSGDTsPRHLS	CDK_group	phosphoELM; RegPhos
T548	VAVVRtPPKSP	PRKACA	HPRD
T50	ESPLQtPTEDG	GSK3B	HPRD; RegPhos
S606	LSNVQsKCGSK	PKN1	RegPhos
T50	ESPLQtPTEDG	PDK1	RegPhos
S673	QSKIGsLDNIT	MARK1(in PHF-tau	RegPhos
T173	RQPSGtGPEDT	PKACa	RegPhos
S622	VPGGGsVQIVY	MARK1	HPRD; RegPhos
S204	KSKIGsTENLK	PRKACA	HPRD
Y711	GAEIVyKSPVV		PhosphoSitePlus
T548	VAVVRtPPKSP	PDK1	RegPhos
S512	KSGDRsGYSSP		PhosphoSitePlus
T123	AAGHVtQARMV		HPRD
S141	RSGYSsPGSPG	PRKACA	HPRD
S515	DRSGYsSPGSP	PDK1	RegPhos
T522	PGSPGtPGSRS	MAPK12	HPRD
S531	RSRTPsLPTPP	PKACa	RegPhos
S641	TSKCGsLGNIH	MARK1	HPRD; RegPhos
S404	VSGDTsPRHLS	CDK5	HPRD
T498	PPAPKtPPSSG	MAPK12	HPRD
S262	LSKVTsKCGSL	PKN1	HPRD
S171	ATRQPsGTGPE		PhosphoSitePlus
S231	LSKVTsKCGSL	MAPK12	HPRD
S214	RSRTPsLPTPP	PRKACA	HPRD
T212	GSRSRtPSLPT	GSK3B	HPRD
T154	GSRSRtPSLPT	GSK3B	HPRD
S633	KPVDLsKVTSK	Tubulin-binding	PhosphoSitePlus
T205	PGSPGtPGSRS	CDK5	HPRD
S231	LSKVTsKCGSL	PKN1	HPRD
S673	QSKIGsLDNIT	PRKCD	HPRD
S338	EIVYKsPVVSG	GSK3B	HPRD
T744	SPQLAtLADEV		PhosphoSitePlus
T147	PGSPGtPGSRS	MAPK12	HPRD
T95	KTKIAtPRGAA	CDK1	HPRD
S46	AGLKEsPLQTP		PhosphoSitePlus; HPRD
S320	SPRHLsNVSST	PRKACA	HPRD
S235	TSKCGsLGNIH	GSK3A	HPRD
S515	DRSGYsSPGSP	PKACa	RegPhos
T498	PPAPKtPPSSG		PhosphoSitePlus
T231	VAVVRtPPKSP	MAPK12	HPRD
T231	VAVVRtPPKSP	GSK3B	HPRD
S673	QSKIGsLDNIT	PKCd	RegPhos
S267	QSKIGsLDNIT	PRKCD	HPRD
S208	PGTPGsRSRTP	GSK3B	HPRD
S713	EIVYKsPVVSG	GSK3B	HPRD; RegPhos
T173	RQPSGtGPEDT	CDK5	RegPhos
T522	PGSPGtPGSRS	PKACa	RegPhos
S267	QSKIGsLDNIT	PRKACA	HPRD
S579	KSKIGsTENLK	CAMK2A	HPRD
T580	SKIGStENLKH		HPRD
T522	PGSPGtPGSRS	CDK5	HPRD; RegPhos
T217	TPSLPtPPTRE	GSK3B	HPRD
S237	PPKSPsSAKSR	PHKG1	HPRD
S412	HLSNVsSTGSI		HPRD
S150	PGTPGsRSRTP	GSK3B	HPRD
S46	AGLKEsPLQTP	PDK1	RegPhos
T522	PGSPGtPGSRS	CDK_group	phosphoELM; RegPhos
Y514	GDRSGySSPGS		PhosphoSitePlus
T534	TPSLPtPPTRE		PhosphoSitePlus
T498	PPAPKtPPSSG	CDK5	RegPhos
S204	KSKIGsTENLK	GSK3B	HPRD
Y305	GAEIVyKSPVV	ABL1	HPRD
S355	DLPEPsEKQPA		RegPhos
T159	TPSLPtPPTRE	GSK3B	HPRD
S501	PKTPPsSGEPP		PhosphoSitePlus
T470	KTKIAtPRGAA	CDK1	HPRD
S358	VSSTGsIDMVD		HPRD
S501	PKTPPsSGEPP	GSK3B	HPRD; RegPhos
T529	GSRSRtPSLPT		PhosphoSitePlus
T529	GSRSRtPSLPT	RSK2	RegPhos
S214	RSRTPsLPTPP	PKN1	HPRD
S202	YSSPGsPGTPG	CDK5	HPRD
S739	IDMVDsPQLAT	CDK5	RegPhos
T154	GSRSRtPSLPT	CDK5	HPRD
T548	VAVVRtPPKSP	CDK5	HPRD; RegPhos
S579	KSKIGsTENLK	GSK3B	HPRD; RegPhos
S356	QSKIGsLDNIT	PRKCD	HPRD
S400	TSTRSsAKTLK	GSK3B	RegPhos
S729	HLSNVsSTGSI		PhosphoSitePlus; HPRD; RegPhos
S637	LSKVTsKCGSL	PKN1	HPRD; RegPhos
S610	QSKCGsKDNIK	MARK1	HPRD; RegPhos
S320	LSKVTsKCGSL	PKN1	HPRD
T175	RIPAKtPPAPK	MAPK1	HPRD
S519	YSSPGsPGTPG	MAPK1	HPRD; SysPTM
S721	VSGDTsPRHLS	CDK5	HPRD; RegPhos
S305	VPGGGsVQIVY	MARK1	HPRD
S293	QSKCGsKDNIK	MARK1	HPRD
S214	RSRTPsLPTPP	RPS6KB1	HPRD
T173	VAVVRtPPKSP	MAPK12	HPRD
S739	IDMVDsPQLAT		PhosphoSitePlus; HPRD; RegPhos
S267	QSKIGsLDNIT	CAMK2A	HPRD
S669	KDRVQsKIGSL	PKN1	HPRD; RegPhos
S519	YSSPGsPGTPG	GSK3B	HPRD; RegPhos; SysPTM
T690	NKKIEtHKLTF	CDK5	HPRD; RegPhos
S298	QSKIGsLDNIT	CAMK2A	HPRD
S515	DRSGYsSPGSP	TTBK1	RegPhos
S298	QSKIGsLDNIT	MARK1	HPRD
T135	KSKDGtGSDDK		HPRD
T315	NKKIEtHKLTF	CDK5	HPRD
T534	TPSLPtPPTRE	CDK5	HPRD; RegPhos
S195	KSGDRsGYSSP	GSK3B	HPRD
S214	KERPGsKEEVD	PKN1	RegPhos
S733	VSSTGsIDMVD	CaMK2_group	RegPhos
S531	RSRTPsLPTPP	PKN1	HPRD; RegPhos
T345	VVSGDtSPRHL		HPRD
S46	AGLKEsPLQTP	GSK3B	HPRD; RegPhos
S519	YSSPGsPGTPG	PDK1	RegPhos; SysPTM
S730	LSNVSsTGSID		PhosphoSitePlus
T403	RSSAKtLKNRP		RegPhos
S140	DRSGYsSPGSP	GSK3B	HPRD
S214	KERPGsKEEVD	CDK5	RegPhos
S354	HLSNVsSTGSI		HPRD
S404	VSGDTsPRHLS	GSK3B	HPRD
S204	KSKIGsTENLK	CAMK2A	HPRD
S238	PPSKAsPAQDG		RegPhos
T212	GSRSRtPSLPT	RPS6KA3	HPRD
S579	KSKIGsTENLK	PHKG1	HPRD
Y711	GAEIVyKSPVV	ABL1	HPRD; RegPhos
T65	AAGHVtQARMV		HPRD
T449	SVTSRtGSSGA		PhosphoSitePlus
T95	AAQPHtEIPEG	CDC2	RegPhos
S235	RTPPKsPSSAK	CDK5	HPRD
T529	GSRSRtPSLPT	CDK5	HPRD; RegPhos
T212	GSRSRtPSLPT	CDK5	HPRD
S137	KSGDRsGYSSP	GSK3B	HPRD
S579	KSKIGsTENLK	PHKg1	RegPhos
S156	RSRTPsLPTPP	CDK5	HPRD
S352	KDRVQsKIGSL	PKN1	HPRD
S413	LSNVSsTGSID	GSK3B	HPRD
S552	RTPPKsPSSAK	GSK-3_beta	phosphoELM
T386	KSKDGtGSDDK		PhosphoSitePlus
T153	KTKIAtPRGAA	CDK1	HPRD
S315	VSGDTsPRHLS	GSK3B	HPRD
T123	PPAPKtPPSSG	MAPK12	HPRD
T123	AAGHVtQEPES	GSK3B	RegPhos
T529	GSRSRtPSLPT	PKACa	RegPhos
S199	RSGYSsPGSPG	CDK5	HPRD
S637	LSKVTsKCGSL	p38g	RegPhos
S730	LSNVSsTGSID	GSK3B	HPRD; RegPhos
S324	LSNVSsTGSID	GSK3B	HPRD
S579	KSKIGsTENLK	CaMK2a	RegPhos
S416	VSSTGsIDMVD		HPRD
T154	GSRSRtPSLPT	PRKACA	HPRD
S311	KSPVVsGDTSP	GSK3B	HPRD
T548	VAVVRtPPKSP	MAPK12	HPRD
S298	QSKIGsLDNIT	PRKCD	HPRD
S156	RSRTPsLPTPP	PKN1	HPRD
T744	SPQLAtLADEV	TTBK1	RegPhos
S73	RMVSKsKDGTG		HPRD
S673	QSKIGsLDNIT	PKACa	RegPhos
T173	VAVVRtPPKSP	CDK5	HPRD
T181	PPAPKtPPSSG	GSK3B	HPRD
S144	YSSPGsPGTPG	CDK5	HPRD
S673	QSKIGsLDNIT	Tubulin-binding	PhosphoSitePlus
T147	PGSPGtPGSRS	CDK5	HPRD
S519	YSSPGsPGTPG	CDK5	HPRD; RegPhos; SysPTM
S126	PKTPPsSGEPP	GSK3B	HPRD
S552	RTPPKsPSSAK	PDK1	RegPhos
T522	PGSPGtPGSRS	GSK3B	HPRD; RegPhos
S516	RSGYSsPGSPG	TTBK1	RegPhos
T498	PPAPKtPPSSG	Erk2	RegPhos
S579	KSKIGsTENLK	GSK3B(GSK3 beta	RegPhos
S144	YSSPGsPGTPG	MAPK1	HPRD
S144	YSSPGsPGTPG		HPRD
S235	QDSPPsKASPA	CDK5	RegPhos
T173	RQPSGtGPEDT	GSK3B	RegPhos
Y336	GAEIVyKSPVV	ABL1	HPRD
S739	IDMVDsPQLAT	TTBK1	RegPhos
S531	RSRTPsLPTPP		PhosphoSitePlus; phosphoELM
S558	PSSAKsRLQTA		PhosphoSitePlus; HPRD
S214	KERPGsKEEVD	PKACa	RegPhos
S204	KSKIGsTENLK	MARK1	HPRD
S210	TPGSRsRTPSL		HPRD
T522	PGSPGtPGSRS		PhosphoSitePlus
T720	VVSGDtSPRHL		PhosphoSitePlus; HPRD; RegPhos
S204	KSKIGsTENLK	PHKG1	HPRD
S202	YSSPGsPGTPG	MAPK12	HPRD
T205	SKIGStENLKH		HPRD
Y627	SVQIVyKPVDL	Tubulin-binding	PhosphoSitePlus
S579	KSKIGsTENLK	GSK-3_beta	phosphoELM
S266	TSKCGsLGNIH	MARK1	HPRD
S726	SPRHLsNVSST		PhosphoSitePlus; RegPhos
S346	VSGDTsPRHLS	CDK5	HPRD
Y18	DHAGTyGLGDR		PhosphoSitePlus
S144	YSSPGsPGTPG	MAPK12	HPRD
S202	YSSPGsPGTPG	MAPK1	HPRD
S179	PPKSPsSAKSR	PHKG1	HPRD
S200	LKNVKsKIGST	PKN1	HPRD
T470	KTKIAtPRGAA	PDK1	RegPhos
S400	KSPVVsGDTSP	GSK3B	HPRD
S320	LSKVTsKCGSL	MAPK12	HPRD
S579	KSKIGsTENLK	Tubulin-binding	PhosphoSitePlus
S519	YSSPGsPGTPG	TTBK1	RegPhos; SysPTM
T205	PGSPGtPGSRS	GSK3B	HPRD
T181	PPAPKtPPSSG	CDK5	HPRD
S641	TSKCGsLGNIH	GSK3A	HPRD; RegPhos
S262	KSKIGsTENLK	RPS6KB1	HPRD
T123	AAGHVtQEPES		HPRD; RegPhos
T529	GSRSRtPSLPT	PRKACA	HPRD
T154	GSRSRtPSLPT	RPS6KA3	HPRD
T173	VAVVRtPPKSP	GSK3B	HPRD
S202	YSSPGsPGTPG		HPRD
S364	IDMVDsPQLAT		HPRD
S396	EIVYKsPVVSG	CDK5	HPRD
S195	KSGDRsGYSSP	PRKACA	HPRD
S516	RSGYSsPGSPG	CDK5	RegPhos
S409	SPRHLsNVSST	PRKACA	HPRD
S579	KSKIGsTENLK	MARK1	HPRD; RegPhos
S141	RSGYSsPGSPG	GSK3B	HPRD
S262	KSKIGsTENLK	GSK3B	HPRD
T498	PPAPKtPPSSG	PDK1	RegPhos
S721	VSGDTsPRHLS	GSK3B	HPRD; RegPhos
S262	KSKIGsTENLK	PRKACA	HPRD
T231	VAVVRtPPKSP	CDK5	HPRD
S516	RSGYSsPGSPG	PKACa	RegPhos
T212	GSRSRtPSLPT	PRKACA	HPRD
T548	VAVVRtPPKSP	GSK3B	HPRD; RegPhos
T492	RIPAKtPPAPK	MAPK1	HPRD
T529	GSRSRtPSLPT	RPS6KA3	HPRD
T731	SNVSStGSIDM		PhosphoSitePlus; RegPhos
T529	GSRSRtPSLPT	CDK_group	phosphoELM; RegPhos
T534	TPSLPtPPTRE	GSK3B	HPRD; RegPhos
S673	QSKIGsLDNIT	PRKACA	HPRD
S531	RSRTPsLPTPP	CDK5	HPRD; RegPhos
S713	EIVYKsPVVSG	CDK5	HPRD; RegPhos
S323	HLSNVsSTGSI		HPRD
S140	DRSGYsSPGSP	PRKACA	HPRD
T373	NKKIEtHKLTF	CDK5	HPRD
S298	QSKIGsLDNIT	PRKACA	HPRD
T498	PPAPKtPPSSG	p38g	RegPhos
T284	NKKIEtHKLTF	CDK5	HPRD
S204	KSKIGsTENLK	PRKCD	HPRD
S733	VSSTGsIDMVD		HPRD; RegPhos
S137	KSGDRsGYSSP	PRKACA	HPRD
S262	LSKVTsKCGSL	MAPK12	HPRD
S144	YSSPGsPGTPG	GSK3B	HPRD
S515	DRSGYsSPGSP	GSK3B	HPRD; RegPhos
S552	RTPPKsPSSAK	CDK_group	phosphoELM; RegPhos
T690	NKKIEtHKLTF	CDK_group	phosphoELM; RegPhos
S202	YSSPGsPGTPG	GSK3B	HPRD
S324	TSKCGsLGNIH	MARK1	HPRD
S156	RSRTPsLPTPP	PRKACA	HPRD
S579	KSKIGsTENLK	PRKACA	HPRD
S266	TSKCGsLGNIH	GSK3A	HPRD
S180	PKSPSsAKSRL		HPRD
Y394	GAEIVyKSPVV	ABL1	HPRD
T537	LPTPPtREPKK		PhosphoSitePlus
S622	VPGGGsVQIVY	MARK1(in PHF-tau	RegPhos
S333	IDMVDsPQLAT		HPRD
T123	PPAPKtPPSSG	GSK3B	HPRD
S351	SPRHLsNVSST	PRKACA	HPRD
S531	RSRTPsLPTPP	PRKACA	HPRD
S356	QSKIGsLDNIT	CAMK2A	HPRD
S512	KSGDRsGYSSP	PRKACA	HPRD
S739	IDMVDsPQLAT	PDK1	RegPhos
S641	TSKCGsLGNIH	Tubulin-binding	PhosphoSitePlus
S177	RTPPKsPSSAK	CDK5	HPRD
S673	QSKIGsLDNIT	CaMK2a	RegPhos
S531	RSRTPsLPTPP	PKA_group	phosphoELM; RegPhos
S307	EIVYKsPVVSG	CDK5	HPRD
T205	PGSPGtPGSRS	MAPK12	HPRD
S579	KSKIGsTENLK	PRKCD	HPRD
S512	KSGDRsGYSSP	GSK3B	HPRD; RegPhos
T548	VAVVRtPPKSP		PhosphoSitePlus; phosphoELM
T548	VAVVRtPPKSP	p38g	RegPhos
S721	VSGDTsPRHLS		PhosphoSitePlus
S238	PKSPSsAKSRL		HPRD
T50	ESPLQtPTEDG		PhosphoSitePlus; HPRD
T173	VAVVRtPPKSP	PRKACA	HPRD
S726	SPRHLsNVSST	PRKACA	HPRD
S516	RSGYSsPGSPG	PRKACA	HPRD
T522	PGSPGtPGSRS	PDK1	RegPhos
S519	YSSPGsPGTPG		PhosphoSitePlus; HPRD; RegPhos; SysPTM
S235	QDSPPsKASPA	MARK1	RegPhos
S267	QSKIGsLDNIT	MARK1	HPRD
S355	LSNVSsTGSID		HPRD
S235	QSKCGsKDNIK	MARK1	HPRD
S338	EIVYKsPVVSG	CDK5	HPRD
S717	KSPVVsGDTSP		PhosphoSitePlus; RegPhos
S214	RSRTPsLPTPP	CDK5	HPRD
S610	QSKCGsKDNIK	MARK1(in PHF-tau	RegPhos
S641	TSKCGsLGNIH	MARK1(in PHF-tau	RegPhos
T492	RIPAKtPPAPK	Erk2	RegPhos
T498	PPAPKtPPSSG	GSK3B	HPRD; RegPhos
S516	RSGYSsPGSPG	PDK1	RegPhos
S552	RTPPKsPSSAK	CDK5	HPRD; RegPhos
T212	GSRSRtPSLPT	RPS6KB1	HPRD
T534	TPSLPtPPTRE	CDK_group	phosphoELM; RegPhos
S717	KSPVVsGDTSP	GSK3B	HPRD; RegPhos
T123	AAGHVtQEPES	p38g	RegPhos
T117	RIPAKtPPAPK	MAPK1	HPRD
S263	KDRVQsKIGSL	PKN1	HPRD
S152	TPGSRsRTPSL		HPRD
T314	VVSGDtSPRHL		HPRD
T529	GSRSRtPSLPT	GSK3B	HPRD; RegPhos
T498	PPAPKtPPSSG	MAPK1	HPRD
S555	PKSPSsAKSRL		PhosphoSitePlus; HPRD; RegPhos
S356	QSKIGsLDNIT	MARK1	HPRD
T529	GSRSRtPSLPT	PDK1	RegPhos
S519	YSSPGsPGTPG	MAPK12	HPRD; SysPTM
S525	PGTPGsRSRTP		PhosphoSitePlus
Y514	GDRSGySSPGS	TTBK1	RegPhos

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S396	DDKKAKTsTRSSAKT	APOE	HPRD
S516	GDRSGYSsPGSPGTP	PPP5C	HPRD
S199	GDRSGYSsPGSPGTP	PPP5C	HPRD
S144	SGYSSPGsPGTPGSR	PPP2CB	HPRD
S144	SGYSSPGsPGTPGSR	PPP2CA	HPRD
S202	SGYSSPGsPGTPGSR	PPP5C	HPRD
S141	GDRSGYSsPGSPGTP	PPP5C	HPRD
S144	SGYSSPGsPGTPGSR	PPP5C	HPRD
S515	SGDRSGYsSPGSPGT	PPP5C	HPRD
S235	SPQDSPPsKASPAQD	APOE	HPRD
S516	GDRSGYSsPGSPGTP	PPP2R5A	HPRD
S140	SGDRSGYsSPGSPGT	PPP5C	HPRD
S519	SGYSSPGsPGTPGSR	PPP5C	HPRD
S198	SGDRSGYsSPGSPGT	PPP5C	HPRD
S519	SGYSSPGsPGTPGSR	PPP2CA	HPRD
S519	SGYSSPGsPGTPGSR	PPP2CB	HPRD
S519	SGYSSPGsPGTPGSR	PPP2R5A	HPRD
S140	SGDRSGYsSPGSPGT	PPP2R5A	HPRD
S141	GDRSGYSsPGSPGTP	PPP2R5A	HPRD
S202	SGYSSPGsPGTPGSR	PPP2CA	HPRD
S202	SGYSSPGsPGTPGSR	PPP2CB	HPRD
S198	SGDRSGYsSPGSPGT	PPP2R5A	HPRD
S515	SGDRSGYsSPGSPGT	PPP2R5A	HPRD
S199	GDRSGYSsPGSPGTP	PPP2R5A	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000262410	S610L	COSMIC	Skin Cancer	21984974
ENSP00000303214	G333V	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000262410	E62K	COSMIC	Head and Neck Cancer	21798893
ENSP00000303214	G304V	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000303214	G273V	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000340820	R364W	BIOMART	Hepatocellular Carcinoma	21930507, 21930502
ENSP00000303214	G302V	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000262410	G650V	COSMIC	Pancreatic Cancer

Differential expressed protein

TAU_HUMAN is not differential expressed protein.

Hyperphosphorylation site

TAU_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
ZAGL2_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
KCC2A_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
PKN1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
TTBK1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
KPCA_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
CDK5_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos; NetPath
PHKG1_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
GSK3B_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
CDK1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
MK01_HUMAN	TAU_HUMAN	kinase -> substrate	KEGG; HPRD
GSK3A_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
MARK1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
ABL1_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD; RegPhos
KPCD_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
KS6A3_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD; RegPhos
KS6B1_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
CD5R1_HUMAN	TAU_HUMAN	kinase -> substrate	KEGG
MK12_HUMAN	TAU_HUMAN	kinase -> substrate	HPRD
PDPK1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
PP2AA_HUMAN	TAU_HUMAN	phosphatase -> substrate	HPRD
2A5A_HUMAN	TAU_HUMAN	phosphatase -> substrate	HPRD
APOE_HUMAN	TAU_HUMAN	phosphatase -> substrate	HPRD
PP2AB_HUMAN	TAU_HUMAN	phosphatase -> substrate	HPRD
PPP5_HUMAN	TAU_HUMAN	phosphatase -> substrate	HPRD

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05010	Alzheimer's disease
hsa04010	MAPK signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0071813	lipoprotein particle binding	IPI	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0008017	microtubule binding	IDA	molecular_function
GO:0035085	cilium axoneme	IEA	cellular_component
GO:0005875	microtubule associated complex	TAS	cellular_component
GO:0030424	axon	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0030426	growth cone	IDA	cellular_component
GO:0007628	adult walking behavior	IEA	biological_process
GO:0047497	mitochondrion transport along microtubule	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0060632	regulation of microtubule-based movement	IEA	biological_process
GO:0017124	SH3 domain binding	IPI	molecular_function
GO:0048699	generation of neurons	NAS	biological_process
GO:0015631	tubulin binding	IEA	molecular_function
GO:0005886	plasma membrane	IDA	cellular_component
GO:0001764	neuron migration	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0048676	axon extension involved in development	IEA	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0008088	axon cargo transport	IEA	biological_process
GO:0045298	tubulin complex	IDA	cellular_component
GO:0010506	regulation of autophagy	IGI	biological_process
GO:0032387	negative regulation of intracellular transport	IEA	biological_process
GO:0005200	structural constituent of cytoskeleton	TAS	molecular_function
GO:0005874	microtubule	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0034399	nuclear periphery	IDA	cellular_component
GO:0031113	regulation of microtubule polymerization	NAS	biological_process
GO:0031116	positive regulation of microtubule polymerization	IDA	biological_process
GO:0006921	cellular component disassembly involved in executi	TAS	biological_process
GO:0000226	microtubule cytoskeleton organization	IDA	biological_process
GO:0007409	axonogenesis	IEA	biological_process
GO:0034185	apolipoprotein binding	IPI	molecular_function
GO:0045773	positive regulation of axon extension	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network