| UniProt/SwissProt ID: | LBR_HUMAN |
| Description: | lamin B receptor [Source:HGNC Symbol;Acc:6518] |
| Location: | chr1 q42.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S130 | FGNSIsRYNGE | PhosphoSitePlus | |
| S80 | RRGSRsRSRSR | HPRD | |
| S97 | KSARRsASASH | PhosphoSitePlus; HPRD | |
| S20 | RWPGSsLYYEV | PhosphoSitePlus | |
| S71 | GSTSSsPSRRR | CDK1 | phosphoELM |
| Y132 | NSISRyNGEPE | PhosphoSitePlus | |
| Y23 | GSSLYyEVEIL | PhosphoSitePlus | |
| T380 | NPRIGtFDLKY | ERG4_ERG24 | PhosphoSitePlus |
| S71 | GSTSSsPSRRR | CDC2(CDK1 | RegPhos |
| S84 | RSRSRsRSPGR | PhosphoSitePlus; HPRD | |
| S67 | QRKGGsTSSSP | PhosphoSitePlus | |
| S78 | SRRRGsRSRSR | HPRD | |
| Y22 | PGSSLyYEVEI | PhosphoSitePlus | |
| Y161 | SQESSyIATQY | PhosphoSitePlus | |
| S86 | RSRSRsPGRPP | PhosphoSitePlus; HPRD | |
| S167 | IATQYsLRPRR | PhosphoSitePlus | |
| S160 | LSQESsYIATQ | PhosphoSitePlus | |
| S71 | GSTSSsPSRRR | PhosphoSitePlus | |
| S101 | RSASAsHQADI | PhosphoSitePlus; HPRD; SysPTM | |
| T284 | KVVEGtPLIDG | ERG4_ERG24 | PhosphoSitePlus |
| T200 | RTFEVtPIRAK | ERG4_ERG24 | PhosphoSitePlus |
| T164 | SSYIAtQYSLR | PhosphoSitePlus | |
| Y166 | YIATQySLRPR | PhosphoSitePlus | |
| T118 | VEVKLtPLILK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S156 | EKFSLsQESSY | PhosphoSitePlus | |
| S99 | ARRSAsASHQA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S128 | KPFGNsISRYN | PhosphoSitePlus | |
| S59 | IKPLTsFRQRK | PhosphoSitePlus | |
| Y385 | TFDLKyFCELR | ERG4_ERG24 | PhosphoSitePlus |
| Dephosphorylation site |
| LBR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339883 | A94G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000272163 | P515L | COSMIC | Melanoma | 21499247 | ENSP00000339883 | F197V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000272163 | A94G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000339883 | P515L | COSMIC | Melanoma | 21499247 | ENSP00000272163 | F197V | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| LBR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LBR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | LBR_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | LBR_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| LBR_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005635 | nuclear envelope | IEA | cellular_component |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group | IEA | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0006695 | cholesterol biosynthetic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005521 | lamin binding | TAS | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0031965 | nuclear membrane | IDA | cellular_component |
| GO:0005639 | integral to nuclear inner membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070087 | chromo shadow domain binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IDA | cellular_component |