| UniProt/SwissProt ID: | ORC1_HUMAN |
| Description: | origin recognition complex, subunit 1 [Source:HGNC Symbol;Acc:8487] |
| Location: | chr1 p32.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S273 | FSEITsPSKRS | CDC2(CDK1 | RegPhos |
| T375 | NEATStPHRIR | PhosphoSitePlus | |
| S273 | FSEITsPSKRS | PhosphoSitePlus | |
| T373 | AQNEAtSTPHR | PhosphoSitePlus | |
| T375 | NEATStPHRIR | CDK1 | phosphoELM |
| T375 | NEATStPHRIR | CDK2 | HPRD; RegPhos |
| S340 | TLTPIsGGQRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S449 | RSSLKsSLHTL | PhosphoSitePlus | |
| S258 | CASLDsPGRIK | PhosphoSitePlus | |
| S287 | KLQTLsPALKA | PhosphoSitePlus; HPRD | |
| S201 | SAESPsWTPAE | PhosphoSitePlus | |
| S850 | VRLNVsQDDVL | PhosphoSitePlus; HPRD | |
| S255 | QTSCAsLDSPG | PhosphoSitePlus | |
| S461 | KVPKKsLKPRT | PhosphoSitePlus | |
| S196 | RAKSKsAESPS | HPRD; phosphoELM | |
| T230 | PTHPLtPRARK | PhosphoSitePlus | |
| S476 | APQIRsRSLAA | HPRD; phosphoELM | |
| S258 | CASLDsPGRIK | CDK2 | HPRD; RegPhos |
| S417 | PAAEIsDSSSD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S275 | EITSPsKRSQP | PhosphoSitePlus | |
| S420 | EISDSsSDEEE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S419 | AEISDsSSDEE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S273 | FSEITsPSKRS | CDK2 | HPRD; RegPhos |
| S450 | SSLKSsLHTLT | PhosphoSitePlus | |
| T203 | ESPSWtPAEHV | PhosphoSitePlus; HPRD; phosphoELM | |
| T375 | NEATStPHRIR | CDC2(CDK1 | RegPhos |
| T226 | SRQTPtHPLTP | HPRD | |
| T455 | SLHTLtKVPKK | PhosphoSitePlus | |
| S194 | PVRAKsKSAES | PhosphoSitePlus | |
| S199 | SKSAEsPSWTP | PhosphoSitePlus; HPRD | |
| T453 | KSSLHtLTKVP | PhosphoSitePlus | |
| S311 | DDKKAsPEHRI | PhosphoSitePlus | |
| S269 | RKVAFsEITSP | PhosphoSitePlus | |
| S258 | CASLDsPGRIK | CDK1 | phosphoELM |
| S383 | RIRRKsSVLTM | PhosphoSitePlus | |
| T224 | SKSRQtPTHPL | PhosphoSitePlus | |
| S478 | QIRSRsLAAQE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S258 | CASLDsPGRIK | CDC2(CDK1 | RegPhos |
| S421 | ISDSSsDEEEA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T337 | EERTLtPISGG | PhosphoSitePlus; HPRD; phosphoELM | |
| S427 | DEEEAsTPPLP | HPRD; phosphoELM | |
| S273 | FSEITsPSKRS | CDK1 | phosphoELM |
| Dephosphorylation site |
| ORC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360623 | L398V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360623 | I317M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360621 | V518M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360621 | L398V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360621 | I317M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360623 | V518M | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ORC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ORC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | ORC1_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | ORC1_HUMAN | kinase -> substrate | RegPhos |
| MK06_HUMAN | ORC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK2_HUMAN | ORC1_HUMAN | kinase -> substrate | RegPhos |
| CDK4_HUMAN | ORC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACVR1_HUMAN | ORC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | regulation of transcription involved in G1/S phase | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0005664 | nuclear origin of replication recognition complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000808 | origin recognition complex | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |