Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ORC1_HUMAN
Description:origin recognition complex, subunit 1 [Source:HGNC Symbol;Acc:8487]
Location:chr1 p32.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S273FSEITsPSKRSCDC2(CDK1RegPhos
T375NEATStPHRIRPhosphoSitePlus
S273FSEITsPSKRSPhosphoSitePlus
T373AQNEAtSTPHRPhosphoSitePlus
T375NEATStPHRIRCDK1phosphoELM
T375NEATStPHRIRCDK2HPRD; RegPhos
S340TLTPIsGGQRSPhosphoSitePlus; HPRD; phosphoELM
S449RSSLKsSLHTLPhosphoSitePlus
S258CASLDsPGRIKPhosphoSitePlus
S287KLQTLsPALKAPhosphoSitePlus; HPRD
S201SAESPsWTPAEPhosphoSitePlus
S850VRLNVsQDDVLPhosphoSitePlus; HPRD
S255QTSCAsLDSPGPhosphoSitePlus
S461KVPKKsLKPRTPhosphoSitePlus
S196RAKSKsAESPSHPRD; phosphoELM
T230PTHPLtPRARKPhosphoSitePlus
S476APQIRsRSLAAHPRD; phosphoELM
S258CASLDsPGRIKCDK2HPRD; RegPhos
S417PAAEIsDSSSDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S275EITSPsKRSQPPhosphoSitePlus
S420EISDSsSDEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S419AEISDsSSDEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S273FSEITsPSKRSCDK2HPRD; RegPhos
S450SSLKSsLHTLTPhosphoSitePlus
T203ESPSWtPAEHVPhosphoSitePlus; HPRD; phosphoELM
T375NEATStPHRIRCDC2(CDK1RegPhos
T226SRQTPtHPLTPHPRD
T455SLHTLtKVPKKPhosphoSitePlus
S194PVRAKsKSAESPhosphoSitePlus
S199SKSAEsPSWTPPhosphoSitePlus; HPRD
T453KSSLHtLTKVPPhosphoSitePlus
S311DDKKAsPEHRIPhosphoSitePlus
S269RKVAFsEITSPPhosphoSitePlus
S258CASLDsPGRIKCDK1phosphoELM
S383RIRRKsSVLTMPhosphoSitePlus
T224SKSRQtPTHPLPhosphoSitePlus
S478QIRSRsLAAQEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S258CASLDsPGRIKCDC2(CDK1RegPhos
S421ISDSSsDEEEAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T337EERTLtPISGGPhosphoSitePlus; HPRD; phosphoELM
S427DEEEAsTPPLPHPRD; phosphoELM
S273FSEITsPSKRSCDK1phosphoELM

Dephosphorylation site
ORC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360623L398VBIOMARTBreast Cancer21930507, 21930502
ENSP00000360623I317MCOSMICOvarian Cancer21720365
ENSP00000360621V518MCOSMICHead and Neck Cancer21798893
ENSP00000360621L398VBIOMARTBreast Cancer21930507, 21930502
ENSP00000360621I317MCOSMICOvarian Cancer21720365
ENSP00000360623V518MCOSMICHead and Neck Cancer21798893

Differential expressed protein
ORC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ORC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANORC1_HUMANkinase -> substrateRegPhos
CDK1_HUMANORC1_HUMANkinase -> substrateRegPhos
MK06_HUMANORC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANORC1_HUMANkinase -> substrateRegPhos
CDK4_HUMANORC1_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANORC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0006270DNA replication initiationTASbiological_process
GO:0005664nuclear origin of replication recognition complexIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0000808origin recognition complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23