Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDC27_HUMAN
Description:cell division cycle 27 [Source:HGNC Symbol;Acc:1728]
Location:chr17 q21.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T244VISPDtVPLGTPhosphoSitePlus; phosphoELM; RegPhos
S369SPTITsPPNALPhosphoSitePlus; phosphoELM
T446KISTItPQIQAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T329IGQTGtKSVFSCDC2(CDK1RegPhos
S393TTKENsKKLKMPhosphoSitePlus; phosphoELM
S438DSSIIsEGKISPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S386LFTSDsSTTKEPhosphoSitePlus; HPRD; phosphoELM
S434ITKLDsSIISEPhosphoSitePlus; HPRD; phosphoELM
S320APSKKsVARIGphosphoELM
S154WSPFEsLCEIGPhosphoSitePlus
T209ETPQDtIELNRPLK1phosphoELM; RegPhos; SysPTM
S222LESSNsKYSLNPhosphoSitePlus; phosphoELM
S252LGTGTsILSKQPhosphoSitePlus; phosphoELM
S435TKLDSsIISEGPLK1RegPhos
S222LESSNsKYSLNCDC2(CDK1RegPhos
T205TVLTEtPQDTICDC2(CDK1RegPhos; SysPTM
T430DSLEItKLDSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T289ILPLEtPSPGDCDK1phosphoELM
S426PNINDsLEITKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S364TPQVLsPTITSCDK1phosphoELM
S334TKSVFsQSGNSPhosphoSitePlus
S364TPQVLsPTITSPhosphoSitePlus; HPRD; phosphoELM
T343NSREVtPILAQPhosphoSitePlus
T205TVLTEtPQDTICDK1phosphoELM; SysPTM
S435TKLDSsIISEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T444EGKIStITPQIPhosphoSitePlus; HPRD
S379LPRRSsRLFTSPhosphoSitePlus
S384SRLFTsDSSTTPhosphoSitePlus; HPRD; phosphoELM
S378ALPRRsSRLFTPhosphoSitePlus
T430DSLEItKLDSSPLK1phosphoELM; RegPhos
S426PNINDsLEITKCDC2(CDK1RegPhos
S291PLETPsPGDGSPhosphoSitePlus; phosphoELM; RegPhos
T205TVLTEtPQDTIPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S821LHAAEsDEF__PhosphoSitePlus
T809QESSMtDADDTHPRD
T304QNYTNtPPVIDPhosphoSitePlus; phosphoELM
T366QVLSPtITSPPPhosphoSitePlus; HPRD; phosphoELM
T289ILPLEtPSPGDCDC2(CDK1RegPhos
T279ALSPLtPSFGIPhosphoSitePlus; phosphoELM
S220LNLESsNSKYSPhosphoSitePlus; HPRD; phosphoELM
T388TSDSStTKENSPhosphoSitePlus; HPRD; phosphoELM
S336SVFSQsGNSREPhosphoSitePlus; HPRD
S434ITKLDsSIISEPLK1phosphoELM; RegPhos
T343NSREVtPILAQCDC2(CDK1RegPhos
S339SQSGNsREVTPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T691EKALDtLNKAITPR_1PhosphoSitePlus
S276GPAALsPLTPSPhosphoSitePlus; phosphoELM
T368LSPTItSPPNAPhosphoSitePlus; phosphoELM
S312VIDVPsTGAPSCDC2(CDK1RegPhos
T264QNKPKtGRSLLPhosphoSitePlus
T313IDVPStGAPSKPhosphoSitePlus; phosphoELM; RegPhos
S312VIDVPsTGAPSPhosphoSitePlus; phosphoELM
S183NCLPNsCTTQVPhosphoSitePlus; phosphoELM
T446KISTItPQIQACDK1phosphoELM; SysPTM
S296SPGDGsYLQNYPhosphoSitePlus; phosphoELM; RegPhos
T289ILPLEtPSPGDPhosphoSitePlus
S426PNINDsLEITKPLK1RegPhos
T446KISTItPQIQAPLK1phosphoELM; RegPhos; SysPTM
T383SSRLFtSDSSTPhosphoSitePlus
S241DSAVIsPDTVPPhosphoSitePlus; phosphoELM
T359PQTSTtPQVLSPhosphoSitePlus; phosphoELM
T343NSREVtPILAQCDK1phosphoELM
S364TPQVLsPTITSCDC2(CDK1RegPhos
S578AGNCFsLQREHTPR_1PhosphoSitePlus
T209ETPQDtIELNRPhosphoSitePlus; RegPhos; SysPTM
T366QVLSPtITSPPCDC2(CDK1RegPhos
Y740KESLVyFLIGKTPR_11PhosphoSitePlus
S192QVPNHsLSHRQPhosphoSitePlus
T329IGQTGtKSVFSPhosphoSitePlus; phosphoELM
T446KISTItPQIQACDC2(CDK1RegPhos; SysPTM
S387FTSDSsTTKENPhosphoSitePlus; HPRD; phosphoELM
S435TKLDSsIISEGCDC2(CDK1RegPhos
S553KDVALsVLSKDPhosphoSitePlus
T203PETVLtETPQDPhosphoSitePlus
T68GHSCTtPQCKYApc3PhosphoSitePlus
T389SDSSTtKENSKPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
CDC27_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000066544V550GCOSMICOvarian Cancer21720365
ENSP00000066544Y604CCOSMICLung Cancer
ENSP00000066544G270ASjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000066544I91fs*54COSMICOvarian Cancer21720365
ENSP00000066544D549ECOSMICOvarian Cancer21720365
ENSP00000066544G744RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CDC27_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDC27_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLK1_HUMANCDC27_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANCDC27_HUMANkinase -> substrateRegPhos
CDK1_HUMANCDC27_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa05166HTLV-I infection
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0070979protein K11-linked ubiquitinationIDAbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0007091mitotic metaphase/anaphase transitionIMPbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005680anaphase-promoting complexIDAcellular_component
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0005819spindleTAScellular_component