Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK08_HUMAN
Description:mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:6881]
Location:chr10 q11.22
Node attribute:PPI(source); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y185FMMTPyVVTRYMAP2K7phosphoELM; RegPhos
S179RTAGTsFMMTPPkinasePhosphoSitePlus
Y185FMMTPyVVTRYMAP2K4HPRD; phosphoELM; RegPhos
Y357WKELIyKEVMDHPRD; RegPhos
T258QPTVRtYVENRHPRD; RegPhos
S377IRGQPsPLAQVHPRD
T367DLEERtKNGVIHPRD; RegPhos
T178ARTAGtSFMMTPkinasePhosphoSitePlus
S155RDLKPsNIVVKPkinasePhosphoSitePlus
T183TSFMMtPYVVTMAP2K7HPRD; phosphoELM; RegPhos
T188TPYVVtRYYRAPkinasePhosphoSitePlus
S377IRGQPsPLGAAHPRD; phosphoELM; RegPhos
Y185FMMTPyVVTRYPkinasePhosphoSitePlus
T183TSFMMtPYVVTPkinasePhosphoSitePlus
T183TSFMMtPYVVTphosphoELM; RegPhos
T255KKLQPtVRTYVHPRD; RegPhos
Y259PTVRTyVENRPHPRD; RegPhos
Y185FMMTPyVVTRYphosphoELM; RegPhos
T243IEQLGtPCPEFPkinasePhosphoSitePlus
Y185FMMTPyVVTRYRETHPRD; RegPhos

Dephosphorylation site
MK08_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363294G177RGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363304G177RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363297L198FTCGAOvarian Cancer21720365, 18772890
ENSP00000353483G171SGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000363304G177RGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363297G171SGreenman2007Renal Cancer17344846, 18428421
ENSP00000363294G177RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000353483G177RGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363297G177RGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363291Q120*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000363304G171SGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000363297G177RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000353483G177RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363294G171SGreenman2007Renal Cancer17344846, 18428421

Differential expressed protein
MK08_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK08_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANDYR1B_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANELK3_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANELK1_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
MK08_HUMANCPZIP_HUMANkinase -> substrateRegPhos
TGFR2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK08_HUMANkinase -> substrateRegPhos
AKT1_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMK08_HUMANkinase -> substrateKEGG; HPRD; RegPhos; NetPath; Robert H Newman (201
MK08_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANKAT5_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANBMF_HUMANkinase -> substrateHPRD
MK08_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANXPA_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRAF1_HUMANkinase -> substrateKEGG
MK08_HUMANFBRL_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANZBT16_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANATF7_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
RAC1_HUMANMK08_HUMANkinase -> substrateKEGG
MK08_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSENP1_HUMANkinase -> substrateNetPath
MK08_HUMANORN_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANZ385A_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANPAX2_HUMANkinase -> substrateNetPath
MK08_HUMANPAXI_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANRNH1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANB2CL1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GRK6_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANFOS_HUMANkinase -> substrateKEGG
MYLK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANMK08_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
MK08_HUMANSUMO1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANGCR_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANJDP2_HUMANkinase -> substrateHPRD
MK08_HUMANP53_HUMANkinase -> substrateKEGG; HPRD; RegPhos
MK08_HUMANIRS1_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
MK08_HUMANJUN_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK08_HUMANSUMO3_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANJUND_HUMANkinase -> substrateKEGG
MK08_HUMANFBX3_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN1433B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
RET_HUMANMK08_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANEDF1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNFAC2_HUMANkinase -> substrateKEGG
MK08_HUMANNFAC4_HUMANkinase -> substrateKEGG
MK08_HUMANMYC_HUMANkinase -> substrateRegPhos
MK08_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANJIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANPPARA_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNCOA4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANETV1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANAPLP2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN1433Z_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK08_HUMANPPARG_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK08_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANBCL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN1433E_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMTF2_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANHNRPK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANFOSL1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANCDN1A_HUMANkinase -> substrateRegPhos
MK08_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANHSF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK08_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANATF2_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK08_HUMANVDAC1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANJUNB_HUMANkinase -> substrateRegPhos
MK08_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANAPBB1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANJIP3_HUMANkinase -> substrateRegPhos
MK08_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANB2L11_HUMANkinase -> substrateRegPhos
MK08_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMITF_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANFOXO4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR4_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANK2C8_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK08_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANATN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK08_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
DUS14_HUMANMK08_HUMANphosphatase -> substrateKEGG
PTN7_HUMANMK08_HUMANphosphatase -> substrateKEGG
RAC1_HUMANMK08_HUMANotherKEGG
KPCT_HUMANMK08_HUMANotherKEGG
MK08_HUMANJUN_HUMANotherKEGG
RAP1A_HUMANMK08_HUMANotherKEGG
TRAF2_HUMANMK08_HUMANotherKEGG
HSP71_HUMANMK08_HUMANotherKEGG
MDS1_HUMANMK08_HUMANotherKEGG
MP2K7_HUMANMK08_HUMANotherKEGG
RHOA_HUMANMK08_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04723Retrograde endocannabinoid signaling
hsa04622RIG-I-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa04012ErbB signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa05164Influenza A
hsa05152Tuberculosis
hsa05212Pancreatic cancer
hsa04621NOD-like receptor signaling pathway
hsa04310Wnt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05131Shigellosis
hsa04910Insulin signaling pathway
hsa05132Salmonella infection
hsa04010MAPK signaling pathway
hsa05169Epstein-Barr virus infection
hsa04914Progesterone-mediated oocyte maturation
hsa05145Toxoplasmosis
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa04510Focal adhesion
hsa04930Type II diabetes mellitus
hsa04912GnRH signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05210Colorectal cancer
hsa04664Fc epsilon RI signaling pathway
hsa04380Osteoclast differentiation
hsa04728Dopaminergic synapse
hsa05160Hepatitis C

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006950response to stressTASbiological_process
GO:0007258JUN phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004705JUN kinase activityIEAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0031063regulation of histone deacetylationIMPbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0007254JNK cascadeIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016301kinase activityIEAmolecular_function
GO:2000017positive regulation of determination of dorsal ideIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0009411response to UVIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0090045positive regulation of deacetylase activityIMPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0007258JUN phosphorylationIDAbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:2001235positive regulation of apoptotic signaling pathwayIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0046686response to cadmium ionIEAbiological_process
GO:0032880regulation of protein localizationIDAbiological_process
GO:0035033histone deacetylase regulator activityIMPmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0001503ossificationIEAbiological_process