Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:1433Z_HUMAN
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [Source:HGNC Symbol;Acc:12855]
Location:chr8 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y149QSQQAyQEAFE14-3-3; CIA30; TPR_12PhosphoSitePlus
Y82QMAREyREKIE14-3-3; FliMPhosphoSitePlus
S184YEILNsPEKACJNK1(MAPK8RegPhos
S58GARRSsWRVVSPKACaRegPhos
S210TLSEEsYKDSTHPRD
S58GARRSsWRVVSPKB_groupphosphoELM
S58GARRSsWRVVSPKA_groupphosphoELM; RegPhos
S45ERNLLsVAYKN14-3-3; FliMPhosphoSitePlus
Y126MKGDYyRYLAE14-3-3; CIA30; TPR_12PhosphoSitePlus
S63SWRVVsSIEQK14-3-3; FliMPhosphoSitePlus
T232LWTSDtQGDEAphosphoELM; RegPhos; SysPTM
S184YEILNsPEKACJNK1RegPhos
Y48LLSVAyKNVVG14-3-3; FliMPhosphoSitePlus
T232LWTSDtQGDEACSNK1A1HPRD; SysPTM
S58GARRSsWRVVSSTK25HPRD
S230LTLWTsDTQGD14-3-3PhosphoSitePlus
T232LWTSDtQGDEACK1_alphaphosphoELM; SysPTM
S184YEILNsPEKACAKT1HPRD; RegPhos
S58GARRSsWRVVSHPRD; phosphoELM
S58GARRSsWRVVSPKCdRegPhos
Y178NFSVFyYEILN14-3-3; CIA30; TPR_12PhosphoSitePlus
Y125KMKGDyYRYLA14-3-3; CIA30; TPR_12PhosphoSitePlus
T205IAELDtLSEESHPRD
T229NLTLWtSDTQG14-3-3PhosphoSitePlus
S184YEILNsPEKAC14-3-3; CIA30; TPR_12PhosphoSitePlus
Y211LSEESyKDSTL14-3-3PhosphoSitePlus
S207ELDTLsEESYK14-3-3PhosphoSitePlus
S58GARRSsWRVVSPRKCDHPRD
S230LTLWTsDTQGDHPRD
S58GARRSsWRVVSAKT1HPRD; RegPhos
T232LWTSDtQGDEACK1a(CK1 alphaRegPhos; SysPTM
S64WRVVSsIEQKT14-3-3; FliMPhosphoSitePlus
S58GARRSsWRVVS14-3-3; FliMPhosphoSitePlus
T194CSLAKtAFDEA14-3-3; TPR_12PhosphoSitePlus
S207ELDTLsEESYKHPRD
T232LWTSDtQGDEA14-3-3PhosphoSitePlus; SysPTM
T232LWTSDtQGDEACK1aRegPhos; SysPTM
S184YEILNsPEKACMAPK8HPRD; phosphoELM
S58GARRSsWRVVSMAPKAPK2HPRD; RegPhos
S184YEILNsPEKACRegPhos
S58GARRSsWRVVSAKT_groupRegPhos
T215SYKDStLIMQL14-3-3PhosphoSitePlus

Dephosphorylation site
1433Z_HUMAN do not have dephosphorylation site.

Mutation site
1433Z_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueUp119072117
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueUp3.119072117
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueUp1.919072117
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueDown0.8119072117
ENSP00000379288Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000379288Esophageal CancerNormal vs. CancertissueUp2.219142970
ENSP00000379288Gastric CancerNormal vs. CancertissueUp15559763
ENSP00000379288Gastric CancerMetastasiscell lineUp1.517022644
ENSP00000379288Gastric CancerNormal vs. CancertissueDown0.519330469
ENSP00000379288Breast CancerNormal vs. CancertissueUp3.320005186
ENSP00000379288Breast CancerNormal vs. CancertissueUp3.820005186
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.4420052998
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.2320052998
ENSP00000379288Breast CancerMetastasiscell lineDown0.5420052998
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.5120052998
ENSP00000379288Breast CancerNormal vs. Cancercell lineUp1.120052998
ENSP00000379288Breast CancerMetastasiscell lineUp2.320052998
ENSP00000379288breast ductal carcinomaNormal vs. CancertissueUp100020534901
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.7120543960
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.6620543960
ENSP00000379288Breast CancerNormal vs. Cancercell lineDown0.6820543960
ENSP00000379288breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000379288Renal CancerNormal vs. CancertissueUp19164279
ENSP00000379288Gastric CancerNormal vs. CancertissueDown0.3215761955

Hyperphosphorylation site
1433Z_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMAN1433Z_HUMANkinase -> substrateRegPhos
MAPK2_HUMAN1433Z_HUMANkinase -> substrateHPRD; RegPhos
STK25_HUMAN1433Z_HUMANkinase -> substrateHPRD
LYN_HUMAN1433Z_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMAN1433Z_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMAN1433Z_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMAN1433Z_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMAN1433Z_HUMANkinase -> substrateRegPhos
KPCD_HUMAN1433Z_HUMANkinase -> substrateHPRD
MK08_HUMAN1433Z_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04110Cell cycle
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa05130Pathogenic Escherichia coli infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0042470melanosomeIEAcellular_component
GO:0014069postsynaptic densityIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0043234protein complexIEAcellular_component
GO:0006626protein targeting to mitochondrionIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0031252cell leading edgeIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0032403protein complex bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0010941regulation of cell deathIEAbiological_process
GO:0006605protein targetingIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0002553histamine secretion by mast cellIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function


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