Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:2AAA_HUMAN
Description:protein phosphatase 2, regulatory subunit A, alpha [Source:HGNC Symbol;Acc:9302]
Location:chr19 q13.41
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S335IKELVsDANQHPhosphoSitePlus; HPRD
S343NQHVKsALASVPhosphoSitePlus
T584AQEALtVLSLAHEATPhosphoSitePlus
S9ADGDDsLYPIAPhosphoSitePlus; HPRD; SysPTM
S554PILDNsTLQSEPhosphoSitePlus

Dephosphorylation site
2AAA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324804R249HCOSMICUterine Cancer21381030
ENSP00000324804T145PCOSMICOvarian Cancer21720365
ENSP00000324804R258CCOSMICOvarian Cancer21381030
ENSP00000324804R183WTCGAOvarian Cancer21720365, 18772890
ENSP00000324804E64GCOSMICBreast Cancer10713707
ENSP00000324804D375fs*8COSMICRenal Cancer20054297
ENSP00000324804S256FCOSMICUterine Cancer21381030
ENSP00000324804V201IBIOMARTBreast Cancer21930507, 21930502
ENSP00000324804R260CCOSMICOvarian Cancer21720365
ENSP00000324804R183WCOSMICUterine Cancer21381030
ENSP00000324804W257CTCGAOvarian Cancer21720365, 18772890
ENSP00000324804R418WCOSMICMelanoma10713707
ENSP00000324804W257GCOSMICUterine Cancer21381030
ENSP00000324804E393QCOSMICLung Cancer20668451
ENSP00000324804R260CTCGAOvarian Cancer21720365, 18772890
ENSP00000324804R182WCOSMICUterine Cancer21381030
ENSP00000324804P179LCOSMICUterine Cancer21381030

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000324804Esophageal CancerNormal vs. CancertissueDown0.4319142970
ENSP00000324804Esophageal CancerNormal vs. CancertissueDown0.4419142970
ENSP00000324804MelanomaTreatment (none vs. kojic acid treatment)cell lineUp1.518630942
ENSP00000324804Gastric CancerNormal vs. CancertissueDown0.5315761955

Hyperphosphorylation site
2AAA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A3_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
2AAA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030155regulation of cell adhesionNASbiological_process
GO:0005634nucleusNAScellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0015630microtubule cytoskeletonNAScellular_component
GO:0005739mitochondrionNAScellular_component
GO:0006672ceramide metabolic processNASbiological_process
GO:0003823antigen bindingIPImolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0016020membraneNAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016070RNA metabolic processTASbiological_process
GO:0008380RNA splicingNASbiological_process
GO:0000188inactivation of MAPK activityNASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0016071mRNA metabolic processTASbiological_process
GO:0000159protein phosphatase type 2A complexIEAcellular_component
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0030111regulation of Wnt receptor signaling pathwayNASbiological_process
GO:0019932second-messenger-mediated signalingNASbiological_process
GO:0070262peptidyl-serine dephosphorylationIEAbiological_process
GO:0007059chromosome segregationIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006470protein dephosphorylationTASbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0010033response to organic substanceNASbiological_process
GO:0005488bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0045595regulation of cell differentiationNASbiological_process
GO:0008601protein phosphatase type 2A regulator activityTASmolecular_function
GO:0000775chromosome, centromeric regionIDAcellular_component
GO:0006275regulation of DNA replicationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030308negative regulation of cell growthNASbiological_process
GO:0040008regulation of growthNASbiological_process
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenTASbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042518negative regulation of tyrosine phosphorylation ofNASbiological_process
GO:0005829cytosolTAScellular_component
GO:0000159protein phosphatase type 2A complexTAScellular_component


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