Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDN1A_HUMAN
Description:cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Source:HGNC Symbol;Acc:1784]
Location:chr6 p21.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T57DFVTEtPLEGDGSK-3_betaphosphoELM
T145RKRRQtSMTDFPKA_groupRegPhos
T145RKRRQtSMTDFPKB_groupphosphoELM
T145RKRRQtSMTDFPKC_alphaphosphoELM
T57DFVTEtPLEGDCDIPhosphoSitePlus
T57DFVTEtPLEGDGSK3B(GSK3 betaRegPhos
S130EQAEGsPGGPGMAPK_groupphosphoELM; RegPhos; SysPTM
T57DFVTEtPLEGDMAPK_groupphosphoELM; RegPhos
S114DHVDLsLSCTLPhosphoSitePlus
T145RKRRQtSMTDFPIM1HPRD; RegPhos
T57DFVTEtPLEGDJNK1RegPhos
S98RRPGTsPALLQMAP3K5phosphoELM
S130EQAEGsPGGPGPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S146KRRQTsMTDFYPKB_groupphosphoELM
S114DHVDLsLSCTLGSK-3_betaphosphoELM
S146KRRQTsMTDFYPKCa(PKC alphaRegPhos
S146KRRQTsMTDFYPhosphoSitePlus
T145RKRRQtSMTDFPIM-1phosphoELM
S153TDFYHsKRRLIDYRK1BphosphoELM; RegPhos
T145RKRRQtSMTDFDAPK3HPRD; RegPhos
S130EQAEGsPGGPGCDK2phosphoELM; RegPhos; SysPTM
S123TLVPRsGEQAEPhosphoSitePlus
S146KRRQTsMTDFYPKC_alphaphosphoELM
S98RRPGTsPALLQPhosphoSitePlus
S130EQAEGsPGGPGJNK1RegPhos; SysPTM
S146KRRQTsMTDFYPIM-1phosphoELM
T145RKRRQtSMTDFAKT_groupRegPhos
S146KRRQTsMTDFYPKC_groupRegPhos
S146KRRQTsMTDFYAKT_groupRegPhos
T145RKRRQtSMTDFPhosphoSitePlus
S160RRLIFsKRKPPKC_groupRegPhos
T57DFVTEtPLEGDMAPK1phosphoELM
T57DFVTEtPLEGDMAPK8HPRD
S130EQAEGsPGGPGMAPK8HPRD; SysPTM
S153TDFYHsKRRLIPhosphoSitePlus
S146KRRQTsMTDFYAKT1HPRD; RegPhos
T145RKRRQtSMTDFAKT1HPRD; RegPhos
T145RKRRQtSMTDFAKT1(PKBRegPhos

Dephosphorylation site
CDN1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244741S31ROMIMOther Cancer7655464 8084608 8807325
ENSP00000362815S31ROMIMOther Cancer7655464 8084608 8807325
ENSP00000362815Q138ECOSMICBreast Cancer20668451
ENSP00000244741R140QCOSMICOvarian Cancer21720365
ENSP00000244741Q138ECOSMICBreast Cancer20668451
ENSP00000384849R140QTCGAOvarian Cancer21720365, 18772890
ENSP00000362815R140QCOSMICOvarian Cancer21720365
ENSP00000384849R140QCOSMICOvarian Cancer21720365
ENSP00000244741E28*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000244741R140QTCGAOvarian Cancer21720365, 18772890
ENSP00000362815R140QTCGAOvarian Cancer21720365, 18772890
ENSP00000384849S31ROMIMOther Cancer7655464 8084608 8807325
ENSP00000384849Q138ECOSMICBreast Cancer20668451

Differential expressed protein
CDN1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDN1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANCDN1A_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANCDN1A_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANCDN1A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
AKT1_HUMANCDN1A_HUMANkinase -> substrateRegPhos
DYR1B_HUMANCDN1A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
DAPK3_HUMANCDN1A_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCDN1A_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDN1A_HUMANkinase -> substrateRegPhos
MK08_HUMANCDN1A_HUMANkinase -> substrateRegPhos
AKT3_HUMANCDN1A_HUMANkinase -> substrateKEGG
P53_HUMANCDN1A_HUMANTF -> target geneKEGG
ZBT17_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
VDR_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
CEBPB_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
RXRA_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
STAT3_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
P63_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
STA5B_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
KLF4_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
P73_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
SP1_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
P53_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
ANDR_HUMANCDN1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04115p53 signaling pathway
hsa05220Chronic myeloid leukemia
hsa05219Bladder cancer
hsa04110Cell cycle
hsa04012ErbB signaling pathway
hsa05169Epstein-Barr virus infection
hsa05166HTLV-I infection
hsa05214Glioma
hsa05218Melanoma
hsa05203Viral carcinogenesis
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa05160Hepatitis C
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007265Ras protein signal transductionIEPbiological_process
GO:0009411response to UVIEAbiological_process
GO:0030332cyclin bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process
GO:0071479cellular response to ionizing radiationIMPbiological_process
GO:0042326negative regulation of phosphorylationIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0045736negative regulation of cyclin-dependent protein kiIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0071850mitotic cell cycle arrestIEAbiological_process
GO:0046685response to arsenic-containing substanceIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0048146positive regulation of fibroblast proliferationIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007050cell cycle arrestIEAbiological_process
GO:0031668cellular response to extracellular stimulusIMPbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0007346regulation of mitotic cell cycleIEAbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:2000379positive regulation of reactive oxygen species metIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0019912cyclin-dependent protein kinase activating kinase IDAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0033158regulation of protein import into nucleus, transloIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0000307cyclin-dependent protein kinase holoenzyme complexIEAcellular_component
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000307cyclin-dependent protein kinase holoenzyme complexIDAcellular_component
GO:0097193intrinsic apoptotic signaling pathwayTASbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0043068positive regulation of programmed cell deathIEAbiological_process
GO:0090400stress-induced premature senescenceTASbiological_process
GO:0090398cellular senescenceIMPbiological_process
GO:0070557PCNA-p21 complexIDAcellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0010243response to organic nitrogenIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0006977DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0032403protein complex bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000086G2/M transition of mitotic cell cycleIMPbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0055093response to hyperoxiaIEAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:2000278regulation of DNA biosynthetic processIEAbiological_process
GO:0004861cyclin-dependent protein kinase inhibitor activityIEAmolecular_function
GO:0010033response to organic substanceIEAbiological_process