| UniProt/SwissProt ID: | ZN363_HUMAN |
| Description: | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:17479] |
| Location: | chr4 q21.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T154 | LEDIHtSRVVA | zf-RING_2 | PhosphoSitePlus |
| Y181 | MLKEGyRCPLC | zf-RING_2 | PhosphoSitePlus |
| Y173 | LHRTCyEEMLK | zf-RING_2 | PhosphoSitePlus |
| S257 | GGRRIsLD | phosphoELM; SysPTM | |
| T171 | HLLHRtCYEEM | zf-RING_2 | PhosphoSitePlus |
| S155 | EDIHTsRVVAH | zf-RING_2 | PhosphoSitePlus |
| S257 | GGRRIsLDQQ_ | PhosphoSitePlus; SysPTM | |
| Dephosphorylation site |
| ZN363_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000321239 | A190V | COSMIC | Pancreatic Cancer | |
| Differential expressed protein |
| ZN363_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZN363_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BMX_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK40_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| P53_HUMAN | ZN363_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04115 | p53 signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032436 | positive regulation of proteasomal ubiquitin-depen | IDA | biological_process |
| GO:0051865 | protein autoubiquitination | IDA | biological_process |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0042787 | protein ubiquitination involved in ubiquitin-depen | IDA | biological_process |
| GO:0042803 | protein homodimerization activity | IPI | molecular_function |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0000151 | ubiquitin ligase complex | IDA | cellular_component |
| GO:0002039 | p53 binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016567 | protein ubiquitination | IDA | biological_process |
| GO:0031398 | positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |