Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:1433B_HUMAN
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [Source:HGNC Symbol;Acc:12849]
Location:chr20 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y130GDYFRyLSEVA14-3-3PhosphoSitePlus
T143DNKQTtVSNSQPKCzRegPhos
T217SYKDStLIMQL14-3-3PhosphoSitePlus
S60GARRSsWRVIS14-3-3; BLOC1_2; FliMPhosphoSitePlus
T2____MtMDKSEPhosphoSitePlus
Y106ELLDKyLIPNA14-3-3; BLOC1_2PhosphoSitePlus
S186YEILNsPEKACJNK1(MAPK8RegPhos; SysPTM
S47ERNLLsVAYKN14-3-3; BLOC1_2; FliMPhosphoSitePlus
S59VGARRsSWRVI14-3-3; BLOC1_2; FliMPhosphoSitePlus
Y151NSQQAyQEAFE14-3-3PhosphoSitePlus
Y120ESKVFyLKMKG14-3-3PhosphoSitePlus
S132YFRYLsEVASGPRKCZHPRD
T32AMKAVtEQGHE14-3-3; BLOC1_2; FliMPhosphoSitePlus
S60GARRSsWRVISPKC_deltaphosphoELM
S132YFRYLsEVASGPKC_zetaphosphoELM
T207IAELDtLNEES14-3-3PhosphoSitePlus
S186YEILNsPEKACMAPK8phosphoELM; SysPTM
S132YFRYLsEVASGPKCzRegPhos
Y180NFSVFyYEILN14-3-3PhosphoSitePlus
S186YEILNsPEKAC14-3-3PhosphoSitePlus; SysPTM
S60GARRSsWRVISHPRD; RegPhos
S132YFRYLsEVASGPKCz(PKC zetaRegPhos
T143DNKQTtVSNSQPRKCZHPRD
S60GARRSsWRVISSDK1RegPhos
Y21EQAERyDDMAA14-3-3; BLOC1_2PhosphoSitePlus
S186YEILNsPEKACHPRD; RegPhos; SysPTM
S60GARRSsWRVISPKCd(PKC deltaRegPhos
T143DNKQTtVSNSQPKCz(PKC zetaRegPhos
S60GARRSsWRVISPDKCphosphoELM
S6LVQKHPRD
Y127KMKGDyFRYLS14-3-3PhosphoSitePlus
Y50LLSVAyKNVVG14-3-3; BLOC1_2; FliMPhosphoSitePlus

Dephosphorylation site
1433B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361930D104ETCGAOvarian Cancer21720365, 18772890
ENSP00000300161D104ECOSMICOvarian Cancer21720365
ENSP00000300161V99ICOSMICRenal Cancer21248752
ENSP00000361930D104ECOSMICOvarian Cancer21720365
ENSP00000300161D104ETCGAOvarian Cancer21720365, 18772890
ENSP00000361930V99ICOSMICRenal Cancer21248752

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361930Breast CancerNormal vs. CancertissueUp1.212096126
ENSP00000361930Prostate CancerMetastasistissueDown0.5218553995
ENSP00000361930MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.3517854218
ENSP00000361930MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp1.417854218
ENSP00000361930breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000361930Neoplasms by Histologic TypeCancer vs. Cancer (sporadic systemic lymphomas (SSLs) vs. primary CNS lymphomas(PCNSLs))cell lineUp18759588

Hyperphosphorylation site
1433B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMAN1433B_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMAN1433B_HUMANkinase -> substrateRegPhos
KPCD_HUMAN1433B_HUMANkinase -> substrateRobert H Newman (2013)
SDK1_HUMAN1433B_HUMANkinase -> substrateRegPhos
MK08_HUMAN1433B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ROR2_HUMAN1433B_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04114Oocyte meiosis
hsa05169Epstein-Barr virus infection
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0035308negative regulation of protein dephosphorylationIDAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0016071mRNA metabolic processTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0050815phosphoserine bindingIPImolecular_function
GO:0051220cytoplasmic sequestering of proteinIDAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0051219phosphoprotein bindingIPImolecular_function
GO:0032403protein complex bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0004497monooxygenase activityIEAmolecular_function
GO:0000186activation of MAPKK activityTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0006605protein targetingIEAbiological_process
GO:0035329hippo signaling cascadeTASbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0043085positive regulation of catalytic activityIDAbiological_process


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