Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK03_HUMAN
Description:mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:6877]
Location:chr16 p11.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T202HTGFLtEYVATPkinase; YukCPhosphoSitePlus
T80PFEHQtYCQRTPkinasePhosphoSitePlus
T202HTGFLtEYVATphosphoELM; RegPhos
S170RDLKPsNLLINPkinase; YukCPhosphoSitePlus
Y203TGFLTeYVATRHPRD
Y204GFLTEyVATRWMAPK3HPRD; SysPTM
T202HTGFLtEYVATMAP2K_groupphosphoELM; RegPhos
Y204GFLTEyVATRWMAP2K1phosphoELM; RegPhos; SysPTM
Y204GFLTEyVATRWMAP2K2HPRD; phosphoELM; RegPhos; SysPTM
T202HTGFLtEYVATMAP2K1phosphoELM; RegPhos
T202HTGFLtEYVATMAP2K2HPRD; phosphoELM; RegPhos
S219EIMLNsKGYTKPkinasePhosphoSitePlus
Y204GFLTEyVATRWMAP2K_groupphosphoELM; SysPTM
T202HTGFLtEYVATErk1RegPhos
Y130METDLyKLLKSPkinase; YukCPhosphoSitePlus
Y210VATRWyRAPEIPkinase; YukCPhosphoSitePlus
T198PEHDHtGFLTEPkinase; YukCPhosphoSitePlus
Y204GFLTEyVATRWPkinase; YukCPhosphoSitePlus; SysPTM
T202HTGFLtEYVATMAPK3HPRD
Y204GFLTEyVATRWHPRD; phosphoELM; RegPhos; SysPTM
T207TEYVAtRWYRAPkinase; YukCPhosphoSitePlus
Y204GFLTEyVATRWErk1RegPhos; SysPTM

Dephosphorylation site
MK03_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263025R359WCOSMICGastric Cancer21097718

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000327293Breast CancerNormal vs. CancertissueUp3.716470630

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T202Pkinase; YukCHDHTGFLtEYVATRWtype 2 diabetes12765939PhosphoSitePlus
Y204Pkinase; YukCHTGFLTEyVATRWYRtype 2 diabetes12765939PhosphoSitePlus
Y204Pkinase; YukCHTGFLTEyVATRWYRmedullary thyroid carcinoma17209045PhosphoSitePlus
T202Pkinase; YukCHDHTGFLtEYVATRWmedullary thyroid carcinoma17209045PhosphoSitePlus
Y204Pkinase; YukCHTGFLTEyVATRWYRtuberous sclerosis17671177PhosphoSitePlus
T202Pkinase; YukCHDHTGFLtEYVATRWtuberous sclerosis17671177PhosphoSitePlus
T202Pkinase; YukCHDHTGFLtEYVATRWpulmonary emphysema14764579PhosphoSitePlus
Y204Pkinase; YukCHTGFLTEyVATRWYRpulmonary emphysema14764579PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANSRBP2_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSYN3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANGRB10_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANLIFR_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMAZ_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMCL1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANGSK3B_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANPYR1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANELK1_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK03_HUMANSTMN1_HUMANkinase -> substrateHPRD
MK03_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANGAB2_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
MK03_HUMANSSBP3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMAD1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANKS6A5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMK03_HUMANkinase -> substrateHPRD
MK03_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSRBP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANGAB1_HUMANkinase -> substrateHPRD
MK03_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMKNK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANPTN7_HUMANkinase -> substrateHPRD
KSYK_HUMANMK03_HUMANkinase -> substrateNetPath
MK03_HUMANIRS1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANARBK1_HUMANkinase -> substrateHPRD
MK03_HUMANADA17_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANPPARA_HUMANkinase -> substrateHPRD
MK03_HUMANCAN2_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANTFE2_HUMANkinase -> substrateHPRD; NetPath
MK03_HUMANFOS_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSH2B1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANLIPS_HUMANkinase -> substrateHPRD
MK03_HUMANSTA5A_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANDUS6_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANKS6A3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCEBPB_HUMANkinase -> substrateRobert H Newman (2013)
MP2K2_HUMANMK03_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK03_HUMANARRB1_HUMANkinase -> substrateHPRD
MK03_HUMANCASP9_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANK2C8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK03_HUMANkinase -> substrateRegPhos
MK03_HUMANRCAN1_HUMANkinase -> substrateHPRD
LYN_HUMANMK03_HUMANkinase -> substrateNetPath
MK03_HUMANCCDC6_HUMANkinase -> substrateHPRD
MK03_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANLCK_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANSMAD2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANTAL1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANHSF1_HUMANkinase -> substrateHPRD
MK03_HUMANSTAT3_HUMANkinase -> substrateHPRD; NetPath
MK03_HUMANSPIB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANTHB_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSTMN2_HUMANkinase -> substrateHPRD
MK03_HUMANCXA1_HUMANkinase -> substrateHPRD
MK03_HUMANRRN3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANETV6_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANNCF1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANPLCB1_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
MK03_HUMANPRG2_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANDUS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANUBF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANCNRG_HUMANkinase -> substrateHPRD
MK03_HUMANETS1_HUMANkinase -> substrateHPRD
MK03_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANHSPB8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANESR1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANB2L11_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCEBPA_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANRPB1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCALD1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K1_HUMANMK03_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK03_HUMANPRGR_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMPIP1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMED1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANPTPRR_HUMANkinase -> substrateHPRD
MK03_HUMANTOP2A_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANIL16_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANRS3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMYB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa04720Long-term potentiation
hsa04960Aldosterone-regulated sodium reabsorption
hsa05010Alzheimer's disease
hsa04350TGF-beta signaling pathway
hsa04910Insulin signaling pathway
hsa04380Osteoclast differentiation
hsa05200Pathways in cancer
hsa04722Neurotrophin signaling pathway
hsa05020Prion diseases
hsa04914Progesterone-mediated oocyte maturation
hsa04621NOD-like receptor signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05145Toxoplasmosis
hsa04724Glutamatergic synapse
hsa05133Pertussis
hsa04912GnRH signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04930Type II diabetes mellitus
hsa04810Regulation of actin cytoskeleton
hsa05220Chronic myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa04062Chemokine signaling pathway
hsa05140Leishmaniasis
hsa05131Shigellosis
hsa05160Hepatitis C
hsa04320Dorso-ventral axis formation
hsa05203Viral carcinogenesis
hsa04150mTOR signaling pathway
hsa04520Adherens junction
hsa05215Prostate cancer
hsa04664Fc epsilon RI signaling pathway
hsa05034Alcoholism
hsa05212Pancreatic cancer
hsa04012ErbB signaling pathway
hsa04662B cell receptor signaling pathway
hsa04726Serotonergic synapse
hsa05210Colorectal cancer
hsa05219Bladder cancer
hsa05214Glioma
hsa05152Tuberculosis
hsa04723Retrograde endocannabinoid signaling
hsa04916Melanogenesis
hsa04730Long-term depression
hsa04725Cholinergic synapse
hsa04010MAPK signaling pathway
hsa04114Oocyte meiosis
hsa04370VEGF signaling pathway
hsa05213Endometrial cancer
hsa04650Natural killer cell mediated cytotoxicity
hsa04540Gap junction
hsa04510Focal adhesion
hsa05216Thyroid cancer
hsa04660T cell receptor signaling pathway
hsa04360Axon guidance
hsa05164Influenza A
hsa04270Vascular smooth muscle contraction
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusTAScellular_component
GO:0005769early endosomeTAScellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0005739mitochondrionTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0070849response to epidermal growth factor stimulusIDAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:2000641regulation of early endosome to late endosome tranTASbiological_process
GO:2000657negative regulation of apolipoprotein bindingIEAbiological_process
GO:0051493regulation of cytoskeleton organizationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005901caveolaTAScellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0031143pseudopodiumIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0032872regulation of stress-activated MAPK cascadeTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0033129positive regulation of histone phosphorylationIMPbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0035066positive regulation of histone acetylationIMPbiological_process
GO:0090170regulation of Golgi inheritanceTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005856cytoskeletonTAScellular_component
GO:0000186activation of MAPKK activityTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005770late endosomeTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0072584caveolin-mediated endocytosisTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0019902phosphatase bindingIPImolecular_function
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0030509BMP signaling pathwayIMPbiological_process
GO:0038083peptidyl-tyrosine autophosphorylationIDAbiological_process
GO:0000165MAPK cascadeNASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000187activation of MAPK activityTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0005925focal adhesionTAScellular_component