Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCT_HUMAN
Description:protein kinase C, theta [Source:HGNC Symbol;Acc:9410]
Location:chr10 p14
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S348GISWEsPLDEVPhosphoSitePlus; HPRD; SysPTM
T538DAKTNtFCGTPHPRD; phosphoELM; RegPhos
T219INSREtMFHKEautocatalysisRegPhos
T307RCLRDtEQIFRPhosphoSitePlus
T542NTFCGtPDYIAPkinasePhosphoSitePlus
Y28EAVNPyCAVLVPhosphoSitePlus
Y545CGTPDyIAPEIPkinasePhosphoSitePlus
T219INSREtMFHKEPRKCQHPRD
S695MFRNFsFMNPGPkinase_CPhosphoSitePlus
S676EKPRLsFADRAHPRD; phosphoELM; RegPhos
Y90TTVELySLAERPhosphoSitePlus
S685RALINsMDQNMPkinase_CPhosphoSitePlus
S370NKERPsLQIKLPhosphoSitePlus
Y90TTVELySLAERLckphosphoELM; RegPhos
S662SPFDCsNFDKEPkinase_CPhosphoSitePlus
Y90TTVELySLAERLCKHPRD; RegPhos
T219INSREtMFHKEPKC_thetaphosphoELM
S323IGLPCsIKNEAPhosphoSitePlus
S685RALINsMDQNMHPRD; phosphoELM; RegPhos
T219INSREtMFHKEPhosphoSitePlus
T536LGDAKtNTFCGHPRD
T219INSREtMFHKEPKCtRegPhos
S676EKPRLsFADRAPkinase_CPhosphoSitePlus
S695MFRNFsFMNPGHPRD; phosphoELM; RegPhos
T51IQKKPtMYPPWPhosphoSitePlus
T538DAKTNtFCGTPPkinasePhosphoSitePlus
T536LGDAKtNTFCGPkinasePhosphoSitePlus
T219INSREtMFHKEPKCt(PKC thetaRegPhos

Dephosphorylation site
KPCT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263125W601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000263125K240NHPIColorectal Cancer17344846
ENSP00000263125C96FDing2008Lung Cancer18948947
ENSP00000263125E671DBIOMARTBreast Cancer21930507, 21930502
ENSP00000380361E608DBIOMARTBreast Cancer21930507, 21930502
ENSP00000263125K240NGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
KPCT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T538PkinaseLGDAKTNtFCGTPDYSLE21983831PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCT_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANKPCT_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KPCT_HUMANNUAK1_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANIKKA_HUMANkinase -> substrateHPRD
KPCT_HUMANAKA10_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANGRM5_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKPCT_HUMANkinase -> substrateRegPhos
KPCT_HUMANSTK39_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
KPCT_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANGRP3_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
KPCT_HUMANHABP4_HUMANkinase -> substrateHPRD
KPCT_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANMOES_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCT_HUMANWIPF1_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
KPCT_HUMANICAM3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCT_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANTRI26_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANIRS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCT_HUMANIKKB_HUMANkinase -> substrateHPRD
KPCT_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANKPCT_HUMANkinase -> substrateHPRD
KPCT_HUMANCAR11_HUMANkinase -> substrateKEGG; NetPath
PLCG1_HUMANKPCT_HUMANotherKEGG
KPCT_HUMANMK08_HUMANotherKEGG
KPCT_HUMANM3K7_HUMANotherKEGG
KPCT_HUMANIKKA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa04660T cell receptor signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05162Measles
hsa04064NF-kappa B signaling pathway
hsa04920Adipocytokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046627negative regulation of insulin receptor signaling IMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0032740positive regulation of interleukin-17 productionISSbiological_process
GO:0030168platelet activationTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0070233negative regulation of T cell apoptotic processIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0032753positive regulation of interleukin-4 productionISSbiological_process
GO:0035556intracellular signal transductionNASbiological_process
GO:0001558regulation of cell growthNASbiological_process
GO:0090330regulation of platelet aggregationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:2000570positive regulation of T-helper 2 cell activationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:2000318positive regulation of T-helper 17 type immune resISSbiological_process
GO:0032740positive regulation of interleukin-17 productionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004697protein kinase C activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityNASmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006509membrane protein ectodomain proteolysisISSbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006509membrane protein ectodomain proteolysisIEAbiological_process
GO:0032753positive regulation of interleukin-4 productionIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005622intracellularNAScellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0050870positive regulation of T cell activationISSbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:2000318positive regulation of T-helper 17 type immune resIEAbiological_process
GO:0045086positive regulation of interleukin-2 biosynthetic IEAbiological_process
GO:0001772immunological synapseIEAcellular_component
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:2000570positive regulation of T-helper 2 cell activationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentISSbiological_process
GO:0090330regulation of platelet aggregationISSbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006468protein phosphorylationNASbiological_process
GO:0050870positive regulation of T cell activationIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function