Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRIP6_HUMAN
Description:thyroid hormone receptor interactor 6 [Source:HGNC Symbol;Acc:12311]
Location:chr7 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T162YTTAStPAGPAPhosphoSitePlus; HPRD; phosphoELM
Y149LPASPyGGPTPPhosphoSitePlus; HPRD; phosphoELM
Y157PTPASyTTASTPhosphoSitePlus
S51FCPLPsEQCYQPhosphoSitePlus
S147SPLPAsPYGGPPhosphoSitePlus; HPRD; phosphoELM
Y320RGQHFyAVERRLIMPhosphoSitePlus
Y131PPPPAyRTGSLPhosphoSitePlus; HPRD; phosphoELM
S92GLRPGsLDAEIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T153PYGGPtPASYTPhosphoSitePlus; HPRD; phosphoELM
Y55PSEQCyQAPGGPhosphoSitePlus
Y332YCEGCyVATLELIMPhosphoSitePlus
S142KPNPAsPLPASPhosphoSitePlus; HPRD; phosphoELM
Y275PPSGEyFGQCGPhosphoSitePlus
T159PASYTtASTPAPhosphoSitePlus
Y123PDRQAyEPPPPPhosphoSitePlus; HPRD
Y122RPDRQaYEPPPHPRD

Dephosphorylation site
TRIP6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000200457L468FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000200457Q278HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000200457T309PCOSMICHepatocellular Carcinoma21822264
ENSP00000200457Q278HCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
TRIP6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRIP6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TRIP6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048041focal adhesion assemblyNASbiological_process
GO:0005149interleukin-1 receptor bindingIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008588release of cytoplasmic sequestered NF-kappaBIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045323interleukin-1 receptor complexIDAcellular_component
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0046966thyroid hormone receptor bindingNASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0019900kinase bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0005925focal adhesionIDAcellular_component
GO:0005515protein bindingIPImolecular_function


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