| UniProt/SwissProt ID: | TRIP6_HUMAN |
| Description: | thyroid hormone receptor interactor 6 [Source:HGNC Symbol;Acc:12311] |
| Location: | chr7 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T162 | YTTAStPAGPA | PhosphoSitePlus; HPRD; phosphoELM | |
| Y149 | LPASPyGGPTP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y157 | PTPASyTTAST | PhosphoSitePlus | |
| S51 | FCPLPsEQCYQ | PhosphoSitePlus | |
| S147 | SPLPAsPYGGP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y320 | RGQHFyAVERR | LIM | PhosphoSitePlus |
| Y131 | PPPPAyRTGSL | PhosphoSitePlus; HPRD; phosphoELM | |
| S92 | GLRPGsLDAEI | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T153 | PYGGPtPASYT | PhosphoSitePlus; HPRD; phosphoELM | |
| Y55 | PSEQCyQAPGG | PhosphoSitePlus | |
| Y332 | YCEGCyVATLE | LIM | PhosphoSitePlus |
| S142 | KPNPAsPLPAS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y275 | PPSGEyFGQCG | PhosphoSitePlus | |
| T159 | PASYTtASTPA | PhosphoSitePlus | |
| Y123 | PDRQAyEPPPP | PhosphoSitePlus; HPRD | |
| Y122 | RPDRQaYEPPP | HPRD | |
| Dephosphorylation site |
| TRIP6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000200457 | L468F | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000200457 | Q278H | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000200457 | T309P | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000200457 | Q278H | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| TRIP6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRIP6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCZ_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMX_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TRIP6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048041 | focal adhesion assembly | NAS | biological_process |
| GO:0005149 | interleukin-1 receptor binding | IDA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008588 | release of cytoplasmic sequestered NF-kappaB | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0045323 | interleukin-1 receptor complex | IDA | cellular_component |
| GO:0030335 | positive regulation of cell migration | IMP | biological_process |
| GO:0046966 | thyroid hormone receptor binding | NAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |