| UniProt/SwissProt ID: | DYR1B_HUMAN |
| Description: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B [Source:HGNC Symbol;Acc:3092] |
| Location: | chr19 q13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y271 | LGQRIyQYIQS | Pkinase | PhosphoSitePlus |
| S276 | YQYIQsRFYRS | Pkinase | PhosphoSitePlus |
| S486 | RTYRYsNRYCG | PhosphoSitePlus | |
| Y271 | LGQRIyQYIQS | autocatalysis | RegPhos |
| Y63 | HINEVyYAKKK | PhosphoSitePlus | |
| Y485 | NRTYRySNRYC | PhosphoSitePlus | |
| Y64 | INEVYyAKKKR | PhosphoSitePlus | |
| Y271 | LGQRIyQYIQS | HPRD; phosphoELM; RegPhos | |
| Y273 | QRIYQyIQSRF | Pkinase | PhosphoSitePlus; SysPTM |
| Y271 | LGQRIyQYIQS | DYRK1B | HPRD; phosphoELM; RegPhos |
| Y111 | RWLERyEIDSL | Pkinase | PhosphoSitePlus |
| Y273 | QRIYQyIQSRF | DYRK1B | HPRD; phosphoELM; RegPhos; SysPTM |
| Y273 | QRIYQyIQSRF | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y273 | QRIYQyIQSRF | autocatalysis | RegPhos; SysPTM |
| Dephosphorylation site |
| DYR1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221803 | Q275R | Greenman2007 | Skin Cancer | 17344846, 18428421 |
| Differential expressed protein |
| DYR1B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DYR1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | DYR1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ZN692_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | NPM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | MDFI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ZMYM3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | KAPCB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ZN606_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | CDN1A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| DYR1B_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | DYR1B_HUMAN | kinase -> substrate | RegPhos |
| DYR1B_HUMAN | FHL2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ERF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | SMAD3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | M18BP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | MK08_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | DYR1B_HUMAN | kinase -> substrate | RegPhos |
| DYR1B_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ZN626_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ZN519_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | HNF1A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| DYR1B_HUMAN | HSFY1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | ACRC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DYR1B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |