Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCOA4_HUMAN
Description:nuclear receptor coactivator 4 [Source:HGNC Symbol;Acc:7671]
Location:chr10 q11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S194EQKSAsGIVAVPhosphoSitePlus
S237QTLENsQTSSRPhosphoSitePlus
S240ENSQTsSRACNPhosphoSitePlus
S456EKHKDsLNMWLPhosphoSitePlus; HPRD; phosphoELM
S241NSQTSsRACNFPhosphoSitePlus
S212GSKPAsGYQAPPhosphoSitePlus
S334KLLFQsYNVNDPhosphoSitePlus
S57IHSCIsRHLECPhosphoSitePlus
S192MPEQKsASGIVHPRD

Dephosphorylation site
NCOA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363200Y71*BIOMARTBreast Cancer21930507, 21930502
ENSP00000390713Y71*BIOMARTBreast Cancer21930507, 21930502
ENSP00000344552S267PCOSMICSkin Cancer21984974
ENSP00000344552Y71*BIOMARTBreast Cancer21930507, 21930502
ENSP00000390713S267PCOSMICSkin Cancer21984974
ENSP00000363200S267PCOSMICSkin Cancer21984974

Differential expressed protein
NCOA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCOA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANNCOA4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNCOA4_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNCOA4_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANNCOA4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NCOA4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003713transcription coactivator activityNASmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0008584male gonad developmentTASbiological_process
GO:0005634nucleusTAScellular_component


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