| UniProt/SwissProt ID: | RU17_HUMAN |
| Description: | small nuclear ribonucleoprotein 70kDa (U1) [Source:HGNC Symbol;Acc:11150] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S281 | RSRERsKDKDR | PhosphoSitePlus | |
| Y414 | DSRDMyMESEG | PhosphoSitePlus | |
| S137 | IHMVYsKRSGK | HPRD | |
| S295 | RRSSRsRERAR | PhosphoSitePlus | |
| Y126 | REFEVyGPIKR | HPRD; phosphoELM | |
| Y146 | GKPRGyAFIEY | RRM_1 | PhosphoSitePlus |
| S140 | VYSKRsGKPRG | HPRD | |
| S140 | VYSKRsGKPRG | RRM_1 | PhosphoSitePlus |
| S357 | RERRRsHRSER | HPRD | |
| T84 | QQEVEtELKMW | U1snRNP70_N | PhosphoSitePlus |
| S226 | ERPGPsPLPHR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S360 | RRSHRsERERR | DUF1777 | PhosphoSitePlus |
| S360 | RRSHRsERERR | HPRD | |
| S257 | RERRRsRSRDR | PhosphoSitePlus | |
| T199 | GGLGGtRRGGA | PhosphoSitePlus | |
| S259 | RRRSRsRDRRR | PhosphoSitePlus | |
| S357 | RERRRsHRSER | DUF1777 | PhosphoSitePlus |
| S277 | EERRRsRERSK | PhosphoSitePlus | |
| S320 | DMAEPsEAGDA | PhosphoSitePlus; HPRD; phosphoELM | |
| S217 | GRDDTsRYDER | PhosphoSitePlus | |
| S293 | RKRRSsRSRER | PhosphoSitePlus | |
| Y112 | VARVNyDTTES | RRM_1 | PhosphoSitePlus |
| Y38 | HHNQPyCGIAP | U1snRNP70_N | PhosphoSitePlus |
| S268 | RRRSRsRDKEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S266 | DRRRRsRSRDK | PhosphoSitePlus; HPRD; phosphoELM | |
| Y126 | REFEVyGPIKR | RRM_1 | PhosphoSitePlus |
| S410 | GLGNDsRDMYM | DUF1777 | PhosphoSitePlus; SysPTM |
| S410 | GLGNDsRDMYM | HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| RU17_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221448 | K87T | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| RU17_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RU17_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK1_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3B_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RU17_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003723 | RNA binding | IMP | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0043484 | regulation of RNA splicing | IMP | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005681 | spliceosomal complex | IDA | cellular_component |