Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RU17_HUMAN
Description:small nuclear ribonucleoprotein 70kDa (U1) [Source:HGNC Symbol;Acc:11150]
Location:chr19 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S281RSRERsKDKDRPhosphoSitePlus
Y414DSRDMyMESEGPhosphoSitePlus
S137IHMVYsKRSGKHPRD
S295RRSSRsRERARPhosphoSitePlus
Y126REFEVyGPIKRHPRD; phosphoELM
Y146GKPRGyAFIEYRRM_1PhosphoSitePlus
S140VYSKRsGKPRGHPRD
S140VYSKRsGKPRGRRM_1PhosphoSitePlus
S357RERRRsHRSERHPRD
T84QQEVEtELKMWU1snRNP70_NPhosphoSitePlus
S226ERPGPsPLPHRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S360RRSHRsERERRDUF1777PhosphoSitePlus
S360RRSHRsERERRHPRD
S257RERRRsRSRDRPhosphoSitePlus
T199GGLGGtRRGGAPhosphoSitePlus
S259RRRSRsRDRRRPhosphoSitePlus
S357RERRRsHRSERDUF1777PhosphoSitePlus
S277EERRRsRERSKPhosphoSitePlus
S320DMAEPsEAGDAPhosphoSitePlus; HPRD; phosphoELM
S217GRDDTsRYDERPhosphoSitePlus
S293RKRRSsRSRERPhosphoSitePlus
Y112VARVNyDTTESRRM_1PhosphoSitePlus
Y38HHNQPyCGIAPU1snRNP70_NPhosphoSitePlus
S268RRRSRsRDKEEPhosphoSitePlus; HPRD; phosphoELM
S266DRRRRsRSRDKPhosphoSitePlus; HPRD; phosphoELM
Y126REFEVyGPIKRRRM_1PhosphoSitePlus
S410GLGNDsRDMYMDUF1777PhosphoSitePlus; SysPTM
S410GLGNDsRDMYMHPRD; phosphoELM; SysPTM

Dephosphorylation site
RU17_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000221448K87TCOSMICSkin Cancer21984974

Differential expressed protein
RU17_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RU17_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK1_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RU17_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006397mRNA processingTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0000398mRNA splicing, via spliceosomeIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003723RNA bindingIMPmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0008380RNA splicingTASbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0043484regulation of RNA splicingIMPbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005681spliceosomal complexIDAcellular_component


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