Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAPK5_HUMAN
Description:mitogen-activated protein kinase-activated protein kinase 5 [Source:HGNC Symbol;Acc:6889]
Location:chr12 q24.12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T182QGDLMtPQFTPMAPK1phosphoELM; SysPTM
T182QGDLMtPQFTPMAPK9phosphoELM; SysPTM
T182QGDLMtPQFTPp38a(MAPK14RegPhos; SysPTM
T182QGDLMtPQFTPMAPK14phosphoELM; SysPTM
T186MTPQFtPYYVAPkinasePhosphoSitePlus
T182QGDLMtPQFTPMAPK11phosphoELM; SysPTM
T182QGDLMtPQFTPp38bRegPhos; SysPTM
T182QGDLMtPQFTPp38aRegPhos; SysPTM
S115LFHRIsQHRHFPkinasePhosphoSitePlus
T182QGDLMtPQFTPp38b(MAPK11RegPhos; SysPTM
T182QGDLMtPQFTPphosphoELM; RegPhos; SysPTM
T182QGDLMtPQFTPErk2(MAPK1RegPhos; SysPTM
Y188PQFTPyYVAPQPkinasePhosphoSitePlus
S206HQKEKsGIIPTPkinasePhosphoSitePlus
S212GIIPTsPTPYTPkinasePhosphoSitePlus
T182QGDLMtPQFTPPkinasePhosphoSitePlus; SysPTM
S472TTSHEsQ____PhosphoSitePlus
T182QGDLMtPQFTPJNK2(MAPK9RegPhos; SysPTM

Dephosphorylation site
MAPK5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000202788*474GCOSMICOvarian Cancer21720365

Differential expressed protein
MAPK5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MAPK5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAPK5_HUMANPOP7_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MAPK5_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANEXOS5_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANZEB2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMAPK5_HUMANkinase -> substrateRegPhos
MAPK5_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCIAO1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANP53_HUMANkinase -> substrateHPRD
MAPK5_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANMAPK5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MAPK5_HUMANHSPB1_HUMANkinase -> substrateKEGG
MAPK5_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANMAPK5_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANMAPK5_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MAPK5_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSF3B4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCLK1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
MAPK5_HUMANUBE2N_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANUBC9_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANGPBP1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANMAPK5_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
MAPK5_HUMANSND1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000165MAPK cascadeTASbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0000187activation of MAPK activityTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0002039p53 bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0051019mitogen-activated protein kinase bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0090400stress-induced premature senescenceIEAbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0006417regulation of translationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0006950response to stressIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032007negative regulation of TOR signaling cascadeIEAbiological_process
GO:0005515protein bindingIEAmolecular_function