Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CHIP_HUMAN
Description:STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:11427]
Location:chr16 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T276TRSPLtQEQLIU-boxPhosphoSitePlus
S273DPVTRsPLTQEU-boxPhosphoSitePlus
Y207AKHDKyMADMDPhosphoSitePlus
T271HFDPVtRSPLTU-boxPhosphoSitePlus
S19GAGGGsPEKSPPhosphoSitePlus; HPRD; phosphoELM
T271HFDPVtRSPLTHPRD
Y49EAAACyGRAITApc3PhosphoSitePlus
S23GSPEKsPSAQEPhosphoSitePlus; HPRD; phosphoELM
S25PEKSPsAQELKPhosphoSitePlus; HPRD
S273DPVTRsPLTQEHPRD; phosphoELM
T276TRSPLtQEQLIHPRD; phosphoELM

Dephosphorylation site
CHIP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000219548F237SCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000219548Lung CancerNormal vs. CancertissueUp12943690
ENSP00000219548Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
CHIP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CHIP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030674protein binding, bridgingTASmolecular_function
GO:0051879Hsp90 protein bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0042405nuclear inclusion bodyIDAcellular_component
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0019900kinase bindingIPImolecular_function
GO:0034450ubiquitin-ubiquitin ligase activityISSmolecular_function
GO:0030911TPR domain bindingIDAmolecular_function
GO:0031371ubiquitin conjugating enzyme complexTAScellular_component
GO:0071218cellular response to misfolded proteinIDAbiological_process
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0030544Hsp70 protein bindingIDAmolecular_function
GO:0000151ubiquitin ligase complexIDAcellular_component
GO:0016567protein ubiquitinationIEAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0006515misfolded or incompletely synthesized protein cataIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0071218cellular response to misfolded proteinIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030579ubiquitin-dependent SMAD protein catabolic processIDAbiological_process
GO:0034450ubiquitin-ubiquitin ligase activityIEAmolecular_function
GO:0031398positive regulation of protein ubiquitinationIDAbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic IDAbiological_process
GO:0051604protein maturationTASbiological_process
GO:0090035positive regulation of chaperone-mediated protein IDAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0031943regulation of glucocorticoid metabolic processIDAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0006515misfolded or incompletely synthesized protein cataIEAbiological_process
GO:0051787misfolded protein bindingIDAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0005829cytosolTAScellular_component


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