Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HSP71_HUMAN
Description:heat shock 70kDa protein 1B [Source:HGNC Symbol;Acc:5233]
Location:chrHSCHR6_MHC_APD p2
Node attribute:PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y525QEAEKyKAEDEphosphoELM
Y611IISGLyQGAGGHPRD; phosphoELM; SysPTM
Y107KVQVSyKGETKHPRD
T222FEVKAtAGDTHHPRD
S106PKVQVsYKGETHPRD
S633KGGSGsGPTIEHPRD
S362RDLNKsINPDEphosphoELM
Y41RTTPSyVAFTDphosphoELM
S631GPKGGsGSGPTHPRD; phosphoELM; SysPTM
S608CNPIIsGLYQGHPRD
Y371DEAVAyGAAVQphosphoELM
T636SGSGPtIEEHPRD

Dephosphorylation site
HSP71_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364801S579*COSMICBreast Cancer17932254

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364801Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2618646787
ENSP00000364801Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000364801Hepatocellular CarcinomaNormal vs. CancertissueUp2.417627933
ENSP00000364801Oral CancerNormal vs. CancertissueDown0.3619297561
ENSP00000364801hepatitis B virusNormal vs. CancertissueUp2014654528
ENSP00000364801hepatitis C virusNormal vs. CancertissueUp2014654528
ENSP00000364801Hepatocellular CarcinomaNormal vs. CancertissueUp2014654528
ENSP00000364801Gastric CancerNormal vs. CancertissueDown0.3119330469
ENSP00000364801Oral CancerNormal vs. CancertissueUp2.319691830
ENSP00000364801chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000364801Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp2.316807943
ENSP00000364801Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp2.916807943
ENSP00000364801Testicular CancerNormal vs. Cancercell lineDown18489135
ENSP00000364801Ovarian CancerMetastasiscell lineUp17892554
ENSP00000364801Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.2219422301
ENSP00000364801Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496
ENSP00000364801Gastric CancerNormal vs. CancertissueDown0.6715761955

Hyperphosphorylation site
HSP71_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HSP71_HUMANMK08_HUMANotherKEGG
SP1_HUMANHSP71_HUMANTF -> target geneTRANSFAC
HSF1_HUMANHSP71_HUMANTF -> target geneTRANSFAC
HSF2_HUMANHSP71_HUMANTF -> target geneTRANSFAC
TBP_HUMANHSP71_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa05164Influenza A
hsa05164Influenza A
hsa05162Measles
hsa04144Endocytosis
hsa05134Legionellosis
hsa04612Antigen processing and presentation
hsa05145Toxoplasmosis
hsa04612Antigen processing and presentation
hsa05162Measles
hsa04144Endocytosis
hsa05169Epstein-Barr virus infection
hsa03040Spliceosome
hsa05145Toxoplasmosis
hsa04010MAPK signaling pathway
hsa05134Legionellosis
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04010MAPK signaling pathway
hsa05020Prion diseases
hsa03040Spliceosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0045648positive regulation of erythrocyte differentiationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016071mRNA metabolic processTASbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0090084negative regulation of inclusion body assemblyIDAbiological_process
GO:0044183protein binding involved in protein foldingIDAmolecular_function
GO:0005739mitochondrionTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005783endoplasmic reticulumTAScellular_component
GO:0008180signalosomeIDAcellular_component
GO:0042026protein refoldingIDAbiological_process
GO:0006402mRNA catabolic processIDAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0051082unfolded protein bindingTASmolecular_function
GO:0000902cell morphogenesisIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0016235aggresomeIDAcellular_component
GO:0016234inclusion bodyIDAcellular_component
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0030308negative regulation of cell growthIMPbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0006986response to unfolded proteinIDAbiological_process


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