Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF4A2_HUMAN
Description:eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:3284]
Location:chr3 q27.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T219SATMPtDVLEVDEADPhosphoSitePlus
Y251GIKQFyINVERPhosphoSitePlus
S79IAQAQsGTGKTDEADPhosphoSitePlus
T81QAQSGtGKTATDEADPhosphoSitePlus
Y71PCIKGyDVIAQDEADPhosphoSitePlus
Y51RGIYAyGFEKPPhosphoSitePlus
T219SATMPtDVLEVHPRD
Y49LLRGIyAYGFEPhosphoSitePlus

Dephosphorylation site
IF4A2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000326381G3VCOSMICOvarian Cancer21720365
ENSP00000326381M316ITCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000326381V181LSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421

Differential expressed protein
IF4A2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y49ESLLRGIyAYGFEKPcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ILK_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IF4A2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016070RNA metabolic processTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006413translational initiationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0000288nuclear-transcribed mRNA catabolic process, deadenTASbiological_process
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0006446regulation of translational initiationTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0016281eukaryotic translation initiation factor 4F compleTAScellular_component
GO:0004386helicase activityTASmolecular_function
GO:0006412translationTASbiological_process


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