Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOSL1_HUMAN
Description:FOS-like antigen 1 [Source:HGNC Symbol;Acc:13718]
Location:chr11 q13.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S251SAHRKsSSSSGPhosphoSitePlus; HPRD
S265SDPLGsPTLLHPRD
T240FTYPStPEPCAPhosphoSitePlus
S265SDPLGsPTLLAPhosphoSitePlus
S253HRKSSsSSGDPPhosphoSitePlus
T223PTLMTtPSLTPPhosphoSitePlus
T217PEALHtPTLMTPhosphoSitePlus
S191TSGTSsPPAPCPhosphoSitePlus
T183AKEGDtGSTSGMacoilinPhosphoSitePlus
S246PEPCAsAHRKSPhosphoSitePlus
S260SGDPSsDPLGSHPRD
S74TYPQYsPPQPRPhosphoSitePlus; phosphoELM
S252AHRKSsSSSGDPhosphoSitePlus
T69YPRPLtYPQYSPhosphoSitePlus
S259SSGDPsSDPLGHPRD
T230SLTPFtPSLVFPhosphoSitePlus

Dephosphorylation site
FOSL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000310170C244FCOSMICHead and Neck Cancer21984974
ENSP00000310170K34RCOSMICOvarian Cancer21720365

Differential expressed protein
FOSL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S252ASAHRKSsSSSGDPScolorectal cancer17371847PhosphoSitePlus
S265PSSDPLGsPTLLAL_colorectal cancer17371847PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANFOSL1_HUMANkinase -> substrateRobert H Newman (2013)
LEF1_HUMANFOSL1_HUMANTF -> target geneKEGG
SP3_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
SP1_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
FOS_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
FOSL2_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
ETS2_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
JUND_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
ETS1_HUMANFOSL1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0051591response to cAMPIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0060674placenta blood vessel developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0007296vitellogenesisIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0009615response to virusTASbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0042734presynaptic membraneIEAcellular_component
GO:0009629response to gravityIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0031668cellular response to extracellular stimulusIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0043005neuron projectionIEAcellular_component


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