Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FBRL_HUMAN
Description:fibrillarin [Source:HGNC Symbol;Acc:3599]
Location:chr19 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S126KRVSIsEGDDKHPRD
S124GEKRVsISEGDFibrillarinPhosphoSitePlus
T208LAKKRtNIIPVHPRD
T208LAKKRtNIIPVFibrillarinPhosphoSitePlus
S124GEKRVsISEGDHPRD; phosphoELM
Y118PGESVyGEKRVFibrillarinPhosphoSitePlus
S116LVPGEsVYGEKFibrillarinPhosphoSitePlus
Y302LTLEPyERDHAFibrillarinPhosphoSitePlus
S126KRVSIsEGDDKFibrillarinPhosphoSitePlus
T298PQEQLtLEPYEFibrillarinPhosphoSitePlus

Dephosphorylation site
FBRL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000221801G47VCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000221801Breast CancerNormal vs. CancertissueDown0.520739354

Hyperphosphorylation site
FBRL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANFBRL_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FBRL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0006396RNA processingIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0008168methyltransferase activityIEAmolecular_function
GO:0001652granular componentIEAcellular_component
GO:0008033tRNA processingIEAbiological_process
GO:0006364rRNA processingIEAbiological_process
GO:0016074snoRNA metabolic processIEAbiological_process
GO:0015030Cajal bodyIDAcellular_component
GO:0031428box C/D snoRNP complexNAScellular_component
GO:0005730nucleolusIEAcellular_component
GO:0001651dense fibrillar componentIEAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0015030Cajal bodyIEAcellular_component


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