Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:B2CL1_HUMAN
Description:BCL2-like 1 [Source:HGNC Symbol;Acc:992]
Location:chr20 q11.21
Node attribute:PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T47ESEMEtPSAINMAPK8phosphoELM
S49EMETPsAINGNPhosphoSitePlus
S62WHLADsPAVNGMAPK8phosphoELM
S62WHLADsPAVNGPhosphoSitePlus
T47ESEMEtPSAINPhosphoSitePlus
T115SQLHItPGTAYBcl-2PhosphoSitePlus
T115SQLHItPGTAYMAPK8phosphoELM

Dephosphorylation site
B2CL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302564Q26KBIOMARTBreast Cancer21930507, 21930502
ENSP00000405563A200TCOSMICCentral Nervous System Neoplasms
ENSP00000365230Q26KBIOMARTBreast Cancer21930507, 21930502
ENSP00000405563Q26KBIOMARTBreast Cancer21930507, 21930502
ENSP00000302564A200TCOSMICCentral Nervous System Neoplasms
ENSP00000365223Q26KBIOMARTBreast Cancer21930507, 21930502
ENSP00000365230A200TCOSMICCentral Nervous System Neoplasms

Differential expressed protein
B2CL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
B2CL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANB2CL1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
B2CL1_HUMANCYC_HUMANotherKEGG
SOS1_HUMANB2CL1_HUMANTF -> target geneKEGG
BCL6_HUMANB2CL1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa05145Toxoplasmosis
hsa05202Transcriptional misregulation in cancer
hsa05200Pathways in cancer
hsa04064NF-kappa B signaling pathway
hsa04210Apoptosis
hsa05212Pancreatic cancer
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05166HTLV-I infection
hsa04630Jak-STAT signaling pathway
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0009314response to radiationIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046898response to cycloheximideIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005741mitochondrial outer membraneNAScellular_component
GO:0008637apoptotic mitochondrial changesTASbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0071780mitotic cell cycle G2/M transition checkpointIMPbiological_process
GO:0031966mitochondrial membraneIEAcellular_component
GO:0009615response to virusIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0044429mitochondrial partIEAcellular_component
GO:0040007growthIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0051434BH3 domain bindingIPImolecular_function
GO:0046902regulation of mitochondrial membrane permeabilityIDAbiological_process
GO:0051881regulation of mitochondrial membrane potentialIDAbiological_process
GO:0097136Bcl-2 family protein complexIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0034097response to cytokine stimulusIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0090201negative regulation of release of cytochrome c froICbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:2001243negative regulation of intrinsic apoptotic signaliIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0071312cellular response to alkaloidIEAbiological_process
GO:0009566fertilizationIEAbiological_process
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0010507negative regulation of autophagyTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0090005negative regulation of establishment of protein loIDAbiological_process
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0060154cellular process regulating host cell cycle in resIEAbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0000910cytokinesisIMPbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0071480cellular response to gamma radiationIEAbiological_process