Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BTK_HUMAN
Description:Bruton agammaglobulinemia tyrosine kinase [Source:HGNC Symbol;Acc:1133]
Location:chrX q22.1
Node attribute:substrate; kinase; effector; Enzyme(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y225VALYDyMPMNAHPRD
Y40HKLSYyEYDFEPHPhosphoSitePlus
Y551VLDDEyTSSVGLynphosphoELM; RegPhos
S180LKPGSsHRKTKPRKCBHPRD
S342CSTPQsQYYLASH2PhosphoSitePlus
Y461KLVQLyGVCTKPkinase_TyrPhosphoSitePlus
Y223KVVALyDYMPMautocatalysisRegPhos
S180LKPGSsHRKTKPKCbRegPhos
Y551VLDDEyTSSVGPkinase_TyrPhosphoSitePlus
Y225VALYDyMPMNASH3_1PhosphoSitePlus
Y551VLDDEyTSSVGLYNHPRD; RegPhos
S366YHQHNsAGLISPhosphoSitePlus
S604ERFTNsETAEHPkinase_TyrPhosphoSitePlus
Y551VLDDEyTSSVGSYKHPRD; RegPhos
S564FPVRWsPPEVLPkinase_TyrPhosphoSitePlus
Y223KVVALyDYMPMAblphosphoELM
Y375ISRLKyPVSQQPhosphoSitePlus
Y223KVVALyDYMPMTECHPRD; RegPhos
S180LKPGSsHRKTKPhosphoSitePlus
S543SDFGLsRYVLDPkinase_TyrPhosphoSitePlus
Y551VLDDEyTSSVGautocatalysisRegPhos
Y361PELINyHQHNSSH2PhosphoSitePlus
S371SAGLIsRLKYPPhosphoSitePlus
Y263NGQEGyIPSNYSH3_1PhosphoSitePlus
Y223KVVALyDYMPMABL1HPRD; RegPhos
T602PYERFtNSETAPkinase_TyrPhosphoSitePlus
Y617QGLRLyRPHLAHPRD; RegPhos
Y344TPQSQyYLAEKRegPhos
Y511CEAMEyLESKQPkinase_TyrPhosphoSitePlus
S21QKKKTsPLNFKPHPhosphoSitePlus
S553DDEYTsSVGSKPkinase_TyrPhosphoSitePlus
S659VMDEEs_____PhosphoSitePlus
Y551VLDDEyTSSVGBTKphosphoELM; RegPhos
Y279DSIEMyEWYSKPhosphoSitePlus
Y345PQSQYyLAEKHSH2PhosphoSitePlus
T191KPLPPtPEEDQPhosphoSitePlus
Y334GVIRHyVVCSTSH2PhosphoSitePlus
Y361PELINyHQHNSHPRD
Y223KVVALyDYMPMBTKHPRD; phosphoELM; RegPhos
Y40HKLSYyEYDFERegPhos
Y551VLDDEyTSSVGphosphoELM
T552LDDEYtSSVGSPkinase_TyrPhosphoSitePlus
Y223KVVALyDYMPMSH3_1PhosphoSitePlus
Y344TPQSQyYLAEKSH2PhosphoSitePlus
Y223KVVALyDYMPMITKHPRD; RegPhos
S55GSKKGsIDVEKPHPhosphoSitePlus
Y223KVVALyDYMPMphosphoELM
S179SLKPGsSHRKTPhosphoSitePlus

Dephosphorylation site
BTK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308176P190KHPINon-small cell lung carcinoma8594569 9016530 17344846
ENSP00000308176S55ABIOMARTBreast Cancer21930507, 21930502
ENSP00000308176P190KGreenman2007Lung Cancer16140923, 17344846, 18428421, 8594569, 9016530, 8594569, 9016530, 17344846

Differential expressed protein
BTK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BTK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG3_HUMANBTK_HUMANGprotein -> effectorgpDB
GBB3_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG5_HUMANBTK_HUMANGprotein -> effectorgpDB
GBB1_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG12_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG8_HUMANBTK_HUMANGprotein -> effectorgpDB
GNAQ_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG11_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG2_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG1_HUMANBTK_HUMANGprotein -> effectorgpDB
GBB2_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG13_HUMANBTK_HUMANGprotein -> effectorgpDB
GBG10_HUMANBTK_HUMANGprotein -> effectorgpDB
GBB5_HUMANBTK_HUMANGprotein -> effectorgpDB
BTK_HUMANNRIP2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANITK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BTK_HUMANSTA5B_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANZN655_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANTGFI1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANBTK_HUMANkinase -> substrateRegPhos
BTK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANBTK_HUMANkinase -> substrateNetPath
BTK_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANIKBA_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANZW10_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANPDCD2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANCND3_HUMANkinase -> substrateRobert H Newman (2013)
KPCB_HUMANBTK_HUMANkinase -> substrateHPRD; NetPath
BTK_HUMANBMX_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BTK_HUMANATF6A_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANCCM2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANWASP_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KSYK_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANKAT5_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANPLCG2_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
BTK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANBTK_HUMANkinase -> substrateKEGG; HPRD; RegPhos; NetPath; Robert H Newman (201
BTK_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANBCAP_HUMANkinase -> substrateNetPath
BTK_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANNELFB_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
TEC_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANSTA5A_HUMANkinase -> substrateHPRD; RegPhos
JAK1_HUMANBTK_HUMANkinase -> substrateNetPath
BTK_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANGTF2I_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
BTK_HUMANNADAP_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANTEC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BTK_HUMANCD19_HUMANkinase -> substrateRegPhos
BTK_HUMANPLCG1_HUMANkinase -> substrateKEGG; NetPath
BTK_HUMANRAD51_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANZN397_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANPER3_HUMANkinase -> substrateRobert H Newman (2013)
PTN6_HUMANBTK_HUMANphosphatase -> substrateKEGG
PI3R5_HUMANBTK_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04064NF-kappa B signaling pathway
hsa05340Primary immunodeficiency
hsa04380Osteoclast differentiation
hsa04664Fc epsilon RI signaling pathway
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042113B cell activationTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0002721regulation of B cell cytokine productionTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0005524ATP bindingTASmolecular_function
GO:0002902regulation of B cell apoptotic processTASbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0097190apoptotic signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayTASbiological_process
GO:0019722calcium-mediated signalingTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0002250adaptive immune responseTASbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0007498mesoderm developmentTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0045579positive regulation of B cell differentiationTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0035556intracellular signal transductionTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048469cell maturationIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process