Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VDAC1_HUMAN
Description:voltage-dependent anion channel 1 [Source:HGNC Symbol;Acc:12669]
Location:chr5 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S101KLTFDsSFSPNTM; Porin_3PhosphoSitePlus
T98RGLKLtFDSSFHPRD
Y195FGGSIyQKVNKHPRD
T107SFSPNtGKKNAPorin_3PhosphoSitePlus
T165AKSRVtQSNFATM; Porin_3PhosphoSitePlus
S193TEFGGsIYQKVTM; Porin_3PhosphoSitePlus
Y225GIAAKyQIDPDTM; Porin_3PhosphoSitePlus
Y67YRWTEyGLTFTPorin_3PhosphoSitePlus
Y173NFAVGyKTDEFHPRD
S102LTFDSsFSPNTHPRD
Y62SLETKyRWTEYTM; Porin_3PhosphoSitePlus
S241KVNNSsLIGLGPorin_3PhosphoSitePlus
T107SFSPNtGKKNAHPRD
S101KLTFDsSFSPNHPRD; phosphoELM
Y195FGGSIyQKVNKTM; Porin_3PhosphoSitePlus
Y22VFTKGyGFGLIPorin_3PhosphoSitePlus
Y247LIGLGyTQTLKTM; Porin_3PhosphoSitePlus
S104FDSSFsPNTGKTM; Porin_3PhosphoSitePlus
S43GLEFTsSGSANTM; Porin_3PhosphoSitePlus
T19ARDVFtKGYGFPorin_3PhosphoSitePlus
S13ADLGKsARDVFPorin_3PhosphoSitePlus
S104FDSSFsPNTGKHPRD; phosphoELM
S240AKVNNsSLIGLPorin_3PhosphoSitePlus
Y67YRWTEyGLTFTHPRD; phosphoELM

Dephosphorylation site
VDAC1_HUMAN do not have dephosphorylation site.

Mutation site
VDAC1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378487papillary thyroid carcinomaNormal vs. CancertissueUp3.816788983
ENSP00000378487Breast CancerNormal vs. Cancercell lineDown0.6120052998
ENSP00000378487Breast CancerNormal vs. Cancercell lineDown0.4720052998
ENSP00000378487Breast CancerMetastasiscell lineDown0.7820052998
ENSP00000378487chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.320417730
ENSP00000378487Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp219422301

Hyperphosphorylation site
VDAC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANVDAC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
VDAC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0055085transmembrane transportIEAbiological_process
GO:0046930pore complexTAScellular_component
GO:0015288porin activityIEAmolecular_function
GO:0008308voltage-gated anion channel activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0005739mitochondrionTAScellular_component
GO:0007612learningIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0006820anion transportTASbiological_process
GO:0016020membraneISScellular_component
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0042645mitochondrial nucleoidIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0001662behavioral fear responseIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0007270neuron-neuron synaptic transmissionIEAbiological_process
GO:0005886plasma membraneIEAcellular_component


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