| UniProt/SwissProt ID: | JUND_HUMAN |
| Description: | jun D proto-oncogene [Source:HGNC Symbol;Acc:6206] |
| Location: | chr19 p13.11 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S315 | LASTAsLLREQ | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| S251 | VPDVPsFGESP | HPRD; phosphoELM | |
| S251 | VPDVPsFGESP | Jun | PhosphoSitePlus |
| S259 | ESPPLsPIDMD | DUF3450; HAP1_N; IncA | PhosphoSitePlus |
| S312 | NTELAsTASLL | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| T308 | LKSQNtELAST | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| T245 | KDEPQtVPDVP | HPRD | |
| T117 | GLVTTtPTSSQ | HPRD | |
| S255 | PSFGEsPPLSP | Jun; IncA | PhosphoSitePlus; SysPTM |
| S259 | ESPPLsPIDMD | HPRD; phosphoELM | |
| T117 | GLVTTtPTSSQ | Jun | PhosphoSitePlus |
| T313 | TELAStASLLR | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| S43 | TAAAGsMMKKD | Jun | PhosphoSitePlus |
| S100 | LLKLAsPELER | HPRD; phosphoELM | |
| T265 | PIDMDtQERIK | HPRD; phosphoELM | |
| S90 | DGLLAsPDLGL | Jun | PhosphoSitePlus |
| T38 | PGAPPtAAAGS | Jun | PhosphoSitePlus |
| S294 | KLERIsRLEEK | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| T71 | AAPPPtPLRAD | Jun | PhosphoSitePlus |
| S100 | LLKLAsPELER | Jun | PhosphoSitePlus |
| S305 | VKTLKsQNTEL | DUF3450; bZIP_1; HAP1_N; | PhosphoSitePlus |
| S255 | PSFGEsPPLSP | HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| JUND_HUMAN do not have dephosphorylation site. |
| Mutation site |
| JUND_HUMAN do not have mutation site. |
| Differential expressed protein |
| JUND_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S100 | Jun | LGLLKLAsPELERLI | ovarian cancer | 17001009 | PhosphoSitePlus | S100 | Jun | LGLLKLAsPELERLI | melanoma skin cancer | 17001009 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | JUND_HUMAN | kinase -> substrate | KEGG |
| JUND_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | IL5_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | INVO_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | SFTPD_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | FOSL1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0009612 | response to mechanical stimulus | IEA | biological_process |
| GO:0009416 | response to light stimulus | IEA | biological_process |
| GO:0007568 | aging | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0071277 | cellular response to calcium ion | IEA | biological_process |
| GO:0045669 | positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0000785 | chromatin | TAS | cellular_component |
| GO:0043434 | response to peptide hormone stimulus | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0014070 | response to organic cyclic compound | IEA | biological_process |
| GO:0007623 | circadian rhythm | IEA | biological_process |
| GO:0002076 | osteoblast development | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016922 | ligand-dependent nuclear receptor binding | IEA | molecular_function |
| GO:0003690 | double-stranded DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |