Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATN1_HUMAN
Description:atrophin 1 [Source:HGNC Symbol;Acc:3033]
Location:chr12 p13.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S77RSEEIsESESEHPRD; phosphoELM; RegPhos
Y783ARSDLyFVPLEHPRD
S896RPHVMsPGNRNAtrophin-1PhosphoSitePlus
S717PAAPAsGPPLSHPRD
S734YETPEsPVPPAMAPK8phosphoELM
S746VPPARsPSPPPHPRD
T653AYKTAtPPGYKHPRD
S101LPRPQsPSDLDAtrophin-1PhosphoSitePlus
S79EEISEsESEETAtrophin-1PhosphoSitePlus
S119NDDGSsDPRDIHPRD; phosphoELM; RegPhos
S63RVEEAsTPKVNHPRD
S661GYKPGsPPSFRAtrophin-1PhosphoSitePlus
S107PSDLDsLDGRSHPRD; phosphoELM; RegPhos
S9RQNKDsMSMRSAtrophin-1PhosphoSitePlus
T669SFRTGtPPGYRHPRD
T646PGAYKtATPPGphosphoELM
S107PSDLDsLDGRSAtrophin-1PhosphoSitePlus
S389AASSSsSSSSSAtrophin-1PhosphoSitePlus
S632GYKTAsPPGPPHPRD
S739YETPEsPVPPAHPRD
S743PARSPsPPPKVphosphoELM; RegPhos
S656GYKPGsPPSFRphosphoELM; RegPhos
S734YETPEsPVPPAMAPK10phosphoELM
S34SRGRAsPGGVSAtrophin-1PhosphoSitePlus
S748PARSPsPPPKVAtrophin-1PhosphoSitePlus
Y729EPAEEyETPESphosphoELM
S81ISESEsEETNAHPRD; phosphoELM
S645GKRAPsPGAYKAtrophin-1PhosphoSitePlus
S661GYKPGsPPSFRHPRD
S739YETPEsPVPPAAtrophin-1PhosphoSitePlus
T653AYKTAtPPGYKAtrophin-1PhosphoSitePlus
S640GKRAPsPGAYKphosphoELM; RegPhos
S11NKDSMsMRSGRAtrophin-1PhosphoSitePlus
S101LPRPQsPSDLDHPRD; phosphoELM; RegPhos
S734YETPEsPVPPAJNK3(MAPK10RegPhos
T669SFRTGtPPGYRAtrophin-1PhosphoSitePlus
T684PAGPGtFKPGSHPRD
S741VPPARsPSPPPphosphoELM; RegPhos
S34SRGRAsPGGVSHPRD; phosphoELM; RegPhos
Y657ATPPGyKPGSPAtrophin-1PhosphoSitePlus
S388AAASSsSSSSSAtrophin-1PhosphoSitePlus
Y905RNHPFyVPLGAAtrophin-1PhosphoSitePlus
S896RPHVMsPGNRNHPRD
S748PARSPsPPPKVHPRD
S103RPQSPsDLDSLHPRD; phosphoELM; RegPhos
S77RSEEIsESESEAtrophin-1PhosphoSitePlus
S112SLDGRsLNDDGHPRD; phosphoELM; RegPhos
S627GYKTAsPPGPPphosphoELM; RegPhos
S734YETPEsPVPPAJNK1(MAPK8RegPhos
T664SFRTGtPPGYRphosphoELM; RegPhos
T691KPGSPtVGPGPHPRD
S390ASSSSsSSSSSAtrophin-1PhosphoSitePlus
S119NDDGSsDPRDIAtrophin-1PhosphoSitePlus
T648AYKTAtPPGYKphosphoELM; RegPhos
S734YETPEsPVPPAphosphoELM; RegPhos
S780NSCARsDLYFVHPRD
S746VPPARsPSPPPAtrophin-1PhosphoSitePlus
S112SLDGRsLNDDGAtrophin-1PhosphoSitePlus
S103RPQSPsDLDSLAtrophin-1PhosphoSitePlus
S722SGPPLsATQIKHPRD
S645GKRAPsPGAYKHPRD
T64VEEAStPKVNKAtrophin-1PhosphoSitePlus
S391SSSSSsSSSSAAtrophin-1PhosphoSitePlus
S168PLFPPsPQPPDAtrophin-1PhosphoSitePlus
Y734EPAEEyETPESHPRD
S39SPGGVsTSSSDAtrophin-1PhosphoSitePlus
S79EEISEsESEETHPRD; phosphoELM; RegPhos
S632GYKTAsPPGPPAtrophin-1PhosphoSitePlus
T651PGAYKtATPPGHPRD

Dephosphorylation site
ATN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000441744E142KTCGAOvarian Cancer21720365, 18772890
ENSP00000349076A1071VTCGAOvarian Cancer21720365, 18772890
ENSP00000379915A1071VTCGAOvarian Cancer21720365, 18772890
ENSP00000379915A1071VCOSMICOvarian Cancer21720365
ENSP00000379915P862LCOSMICSkin Cancer21984974
ENSP00000379915E806KCOSMICBreast Cancer17932254
ENSP00000379915E142KCOSMICOvarian Cancer21720365
ENSP00000379915E142KTCGAOvarian Cancer21720365, 18772890
ENSP00000349076E142KTCGAOvarian Cancer21720365, 18772890
ENSP00000441744A1071VTCGAOvarian Cancer21720365, 18772890
ENSP00000379915P852QCOSMICBreast Cancer17932254
ENSP00000379915S575FCOSMICSkin Cancer21984974

Differential expressed protein
ATN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ATN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANATN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANATN1_HUMANkinase -> substrateRegPhos
MK08_HUMANATN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
ATN1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0007417central nervous system developmentTASbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030011maintenance of cell polarityIEAbiological_process
GO:0050827toxin receptor bindingIEAmolecular_function
GO:0016477cell migrationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016363nuclear matrixIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0051402neuron apoptotic processIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009404toxin metabolic processIEAbiological_process
GO:0019904protein domain specific bindingIPImolecular_function
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process


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