| UniProt/SwissProt ID: | EF2K_HUMAN |
| Description: | eukaryotic elongation factor-2 kinase [Source:HGNC Symbol;Acc:24615] |
| Location: | chr16 p12.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T340 | AVNQNtKLLQS | PhosphoSitePlus | |
| S78 | GSPANsFHFKE | AMPKa2 | RegPhos |
| S398 | LPSSPsSATPH | PRKAA1 | HPRD |
| S398 | LPSSPsSATPH | PRKAA2 | HPRD |
| S366 | QVRTLsGSRPP | PhosphoSitePlus | |
| S416 | HWPVFsDLDNM | PhosphoSitePlus | |
| S396 | DSLPSsPSSAT | eEF2K | RegPhos |
| S366 | RVRTLsGSRPP | RPS6KA1 | HPRD |
| S396 | DSLPSsPSSAT | JNK2 | RegPhos |
| S396 | DSLPSsPSSAT | JNK1 | RegPhos |
| S477 | EDSLGsSGRVC | PhosphoSitePlus; HPRD; phosphoELM | |
| S396 | DSLPSsPSSAT | PhosphoSitePlus; phosphoELM | |
| S27 | GHDGDsDGDSD | PhosphoSitePlus; HPRD; RegPhos | |
| S78 | GSPANsFHFKE | AMPKa1 | RegPhos |
| S395 | FDSLPsSPSSA | PhosphoSitePlus | |
| S366 | RVRTLsGSRPP | p70S6K | RegPhos |
| S491 | WNLLNsSRLHL | PhosphoSitePlus | |
| S399 | PSSPSsATPHS | PhosphoSitePlus | |
| S366 | RVRTLsGSRPP | p70S6K_group | phosphoELM |
| S500 | HLPRAsAVALE | PRKACA | HPRD |
| S135 | LIKMAsQPFGR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S31 | DSDGDsDDEEG | PhosphoSitePlus; HPRD; RegPhos | |
| S366 | RVRTLsGSRPP | RSK3 | RegPhos |
| S380 | PLSENsGDENM | PhosphoSitePlus | |
| S78 | GSPANsFHFKE | AMPK_group | phosphoELM; RegPhos |
| S78 | GSPANsFHFKE | PhosphoSitePlus | |
| S396 | DSLPSsPSSAT | p38b | RegPhos |
| S396 | DSLPSsPSSAT | p38d | RegPhos |
| S366 | RVRTLsGSRPP | RPS6KB1 | HPRD |
| S71 | SERYSsSGSPA | RegPhos | |
| S441 | ENSGDsGYPSE | PhosphoSitePlus | |
| S392 | DVTFDsLPSSP | PhosphoSitePlus | |
| S66 | SNLTKsERYSS | PhosphoSitePlus | |
| S366 | RVRTLsGSRPP | AMPK_group | phosphoELM; RegPhos |
| S366 | RVRTLsGSRPP | p70_group | RegPhos |
| T401 | SPSSAtPHSQK | PhosphoSitePlus | |
| S377 | LLRPLsENSGD | PhosphoSitePlus | |
| S18 | VDGGQsPRAGH | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S359 | EEKCGsPRVRT | p38d(MAPK13 | RegPhos |
| S396 | DSLPSsPSSAT | p38a | RegPhos |
| S500 | HLPRAsAVALE | PKACa | RegPhos |
| Y37 | DDEEGyFICPI | PhosphoSitePlus | |
| Y600 | TKGFDyLLKAA | PhosphoSitePlus; HPRD | |
| S359 | EEKCGsPQVRT | PhosphoSitePlus | |
| S396 | DSLPSsPSSAT | MAPK14 | HPRD |
| S396 | DSLPSsPSSAT | MAPK13 | HPRD |
| S396 | DSLPSsPSSAT | MAPK8 | HPRD |
| S396 | DSLPSsPSSAT | MAPK9 | HPRD |
| Y468 | YSNRKyESDED | HPRD; phosphoELM | |
| S366 | RVRTLsGSRPP | PRKACA | HPRD |
| S61 | VNKYYsNLTKS | PhosphoSitePlus | |
| S78 | GSPANsFHFKE | PRKAA2 | HPRD |
| S78 | GSPANsFHFKE | PRKAA1 | HPRD |
| S72 | ERYSSsGSPAN | PhosphoSitePlus; HPRD; phosphoELM | |
| S398 | LPSSPsSATPH | AMPKa2 | RegPhos |
| S398 | LPSSPsSATPH | AMPKa1 | RegPhos |
| S366 | RVRTLsGSRPP | PKACa | RegPhos |
| S474 | ESDEDsLGSSG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S359 | EEKCGsPRVRT | MAPK13 | HPRD; phosphoELM |
| T353 | TILRGtEEKCG | PhosphoSitePlus | |
| S445 | DSGYPsEKRGE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S377 | LLRPLsENSGD | MAPKAPK2 | HPRD; phosphoELM; RegPhos |
| S377 | LLRPLsENSGD | MAPKAPK5 | HPRD; RegPhos |
| S366 | RVRTLsGSRPP | AMPKa2 | RegPhos |
| S366 | RVRTLsGSRPP | AMPKa1 | RegPhos |
| Y236 | YIEGKyIKYNS | Alpha_kinase | PhosphoSitePlus |
| Y69 | TKSERySSSGS | HPRD; RegPhos | |
| S500 | HLPRAsAVALE | PhosphoSitePlus | |
| S366 | RVRTLsGSRPP | RSK_group | phosphoELM; RegPhos |
| S366 | RVRTLsGSRPP | PRKAA1 | HPRD |
| S366 | RVRTLsGSRPP | PRKAA2 | HPRD |
| S359 | EEKCGsPRVRT | p38d | RegPhos |
| S396 | DSLPSsPSSAT | p38g | RegPhos |
| T364 | SPQVRtLSGSR | PhosphoSitePlus | |
| Y59 | SKVNKyYSNLT | PhosphoSitePlus | |
| S74 | YSSSGsPANSF | PhosphoSitePlus; HPRD; phosphoELM | |
| Y60 | KVNKYySNLTK | PhosphoSitePlus | |
| S377 | LLRPLsENSGD | MAPKAPK3 | HPRD; RegPhos |
| Y443 | SGDSGyPSEKR | PhosphoSitePlus | |
| S70 | KSERYsSSGSP | PhosphoSitePlus; HPRD; RegPhos | |
| S470 | NRKYEsDEDSL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S398 | LPSSPsSATPH | AMPK_group | phosphoELM; RegPhos |
| S398 | LPSSPsSATPH | PhosphoSitePlus | |
| T348 | LQSAKtILRGT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S396 | DSLPSsPSSAT | MAPK12 | HPRD |
| S396 | DSLPSsPSSAT | MAPK11 | HPRD |
| Dephosphorylation site |
| EF2K_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263026 | Y533* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263026 | T291M | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000263026 | Q632H | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000263026 | T291M | HPI | Colorectal Cancer | 17344846 |
| Differential expressed protein |
| EF2K_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EF2K_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | EF2K_HUMAN | kinase -> substrate | RegPhos |
| KS6A1_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| KS6A2_HUMAN | EF2K_HUMAN | kinase -> substrate | RegPhos |
| EF2K_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| MAPK5_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; RegPhos |
| EF2K_HUMAN | BAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EF2K_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EF2K_HUMAN | TULP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EF2K_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK3_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; RegPhos |
| EF2K_HUMAN | NXF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EF2K_HUMAN | EF2_HUMAN | kinase -> substrate | HPRD |
| AAPK1_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| MK14_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| MK08_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MAPK2_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MK12_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| EF2K_HUMAN | AAPK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MK13_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK11_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| KS6B1_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| AAPK2_HUMAN | EF2K_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| EF2K_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006414 | translational elongation | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0031952 | regulation of protein autophosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0008135 | translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0004686 | elongation factor-2 kinase activity | IEA | molecular_function |
| GO:0004686 | elongation factor-2 kinase activity | IDA | molecular_function |
| GO:0005516 | calmodulin binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |