Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RXRA_HUMAN
Description:retinoid X receptor, alpha [Source:HGNC Symbol;Acc:10477]
Location:chr9 q34.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S21NSSLTsPTGRGHPRD; phosphoELM
S260GLNPSsPNDPVErk1(MAPK3RegPhos
S260GLNPSsPNDPVMAPK_groupphosphoELM; RegPhos
T82MSVPTtPTLGFMAPK_groupphosphoELM; RegPhos
Y150KHYGVySCEGCzf-C4PhosphoSitePlus
T82MSVPTtPTLGFNuc_recep-AF1PhosphoSitePlus
S260GLNPSsPNDPVErk2(MAPK1RegPhos
S260GLNPSsPNDPVHormone_recepPhosphoSitePlus
S260GLNPSsPNDPVMAPK1HPRD; phosphoELM
S260GLNPSsPNDPVMAPK7HPRD
Y403ASLEAyCKHKYHormone_recepPhosphoSitePlus
Y397LREKVyASLEAHormone_recepPhosphoSitePlus
Y249PKTETyVEANMMAP2K4phosphoELM; RegPhos
S260GLNPSsPNDPVMAPK3phosphoELM
T82MSVPTtPTLGFMAPK7HPRD
S21NSSLTsPTGRGNuc_recep-AF1PhosphoSitePlus
Y249PKTETyVEANMPhosphoSitePlus
S32SMAAPsLHPSLNuc_recep-AF1PhosphoSitePlus
S260GLNPSsPNDPVErk2RegPhos
S32SMAAPsLHPSLphosphoELM; RegPhos
S260GLNPSsPNDPVErk5RegPhos
S27PTGRGsMAAPSNuc_recep-AF1PhosphoSitePlus
T82MSVPTtPTLGFErk5RegPhos

Dephosphorylation site
RXRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000419692R426HCOSMICHead and Neck Cancer21798897
ENSP00000419692Y397CTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
RXRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S260Hormone_recepNMGLNPSsPNDPVTNhepatocellular carcinoma11826406PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3A_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANRXRA_HUMANkinase -> substrateRegPhos
MK03_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANRXRA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK01_HUMANRXRA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK08_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANRXRA_HUMANkinase -> substrateHPRD
AKT1_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
RXRA_HUMANEGFR_HUMANTF -> target geneTRANSFAC
RXRA_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
RXRA_HUMANRARB_HUMANTF -> target geneTRANSFAC
RXRA_HUMANCABP1_HUMANTF -> target geneTRANSFAC
RXRA_HUMANACADM_HUMANTF -> target geneTRANSFAC
RXRA_HUMANRARG_HUMANTF -> target geneTRANSFAC
RXRA_HUMANADH1G_HUMANTF -> target geneTRANSFAC
RXRA_HUMANPLTP_HUMANTF -> target geneTRANSFAC
RXRA_HUMANRET4_HUMANTF -> target geneTRANSFAC
RXRA_HUMANAPOA1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05216Thyroid cancer
hsa03320PPAR signaling pathway
hsa04976Bile secretion
hsa05223Non-small cell lung cancer
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0044323retinoic acid-responsive element bindingIDAmolecular_function
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048384retinoic acid receptor signaling pathwayIMPbiological_process
GO:0008203cholesterol metabolic processTASbiological_process
GO:0003708retinoic acid receptor activityTASmolecular_function
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001893maternal placenta developmentIEAbiological_process
GO:00048869-cis retinoic acid receptor activityIEAmolecular_function
GO:0055012ventricular cardiac muscle cell differentiationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIDAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0042809vitamin D receptor bindingIPImolecular_function
GO:0007566embryo implantationIEAbiological_process
GO:0048384retinoic acid receptor signaling pathwayIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0006766vitamin metabolic processTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0060528secretory columnal luminar epithelial cell differeIEAbiological_process
GO:0032526response to retinoic acidIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0070644vitamin D response element bindingIDAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0060038cardiac muscle cell proliferationIEAbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0055010ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0019048virus-host interactionIDAbiological_process
GO:0001890placenta developmentIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0060687regulation of branching involved in prostate glandIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0035357peroxisome proliferator activated receptor signaliIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0010467gene expressionTASbiological_process