Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GCR_HUMAN
Description:nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [Source:HGNC Symbol;Acc:7978]
Location:chr5 q31.3
Node attribute:TF; PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S226ENCLLsPLAGEErk2RegPhos
Y301KLGTVyCQASFGCRPhosphoSitePlus
S650HMLYVsSELHRHPRD
T38LRGGAtVKVSAHPRD
T32MDFYKtLRGGAHPRD
S132ANLNRsTSVPEGCRPhosphoSitePlus
S267DLVLSsPSNVTHPRD; phosphoELM; SysPTM
S305VYCQAsFPGANGCRPhosphoSitePlus
S79QQPDLsKAVSLGCRPhosphoSitePlus
S266GDLVLsSPSNVHPRD
S508ATTGVsQETSEDNA-PKphosphoELM
T95MGETEtKVMGNGCRPhosphoSitePlus
T93LYMGEtETKVMGCRPhosphoSitePlus
S226ENCLLsPLAGEMAPK_groupphosphoELM; RegPhos
S226ENCLLsPLAGEJNK1RegPhos
S651MLYVSsELHRLHPRD
S226ENCLLsPLAGEMAPK1HPRD
S226ENCLLsPLAGEMAPK8HPRD
S267DLVLSsPSNVTGCRPhosphoSitePlus; SysPTM
Y89LSMGLyMGETEGCRPhosphoSitePlus
S226ENCLLsPLAGEJNK_groupphosphoELM; RegPhos
S226ENCLLsPLAGEphosphoELM; RegPhos
S651HMLYVsSELHRHPRD
S134LNRSTsVPENPGCRPhosphoSitePlus; SysPTM
S44VKVSAsSPSLAGCRPhosphoSitePlus
T133NLNRStSVPENGCRPhosphoSitePlus
S234AGEDDsFLLEGHPRD; phosphoELM
S509ATTGVsQETSEPRKDCHPRD
Y649CKHMLyVSSELHPRD
T38LRGGAtVKVSAGCRPhosphoSitePlus
S211KETNEsPWRSDHPRD; phosphoELM; RegPhos
S56ASQSDsKQRRLGCRPhosphoSitePlus
S113GQISLsSGETDHPRD; phosphoELM; RegPhos
S203EFSSGsPGKETHPRD; phosphoELM; RegPhos
S508ATTGVsQETSEDNAPKRegPhos
S404RPDVSsPPSSSPhosphoSitePlus
S211KETNEsPWRSDGCRPhosphoSitePlus
T8SKESLtPGREEPhosphoSitePlus; HPRD; phosphoELM
S203EFSSGsPGKETGCRPhosphoSitePlus
Y30DVMDFyKTLRGGCRPhosphoSitePlus
Y648CKHMLyVSSELHPRD
S45KVSASsPSLAVHPRD; phosphoELM; SysPTM
S508ATTGVsQETSEPRKDCHPRD
S226ENCLLsPLAGEGCRPhosphoSitePlus
S317IGNKMsAISVHGCRPhosphoSitePlus
S45KVSASsPSLAVGCRPhosphoSitePlus; SysPTM
T32MDFYKtLRGGAGCRPhosphoSitePlus
S141PENPKsSASTAHPRD; phosphoELM; RegPhos
S652MLYVSsELHRLHPRD
S134LNRSTsVPENPHPRD; phosphoELM; SysPTM

Dephosphorylation site
GCR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343205L753FHPILeukemia8358735 8316249 10766198 8938150 8895760 7812967
ENSP00000231509P531LCOSMICSkin Cancer21984974
ENSP00000231509L773PCOSMICOvarian Cancer21720365
ENSP00000377977C421YHPILeukemia8358735 7823916
ENSP00000343205C421YHPILeukemia8358735 7823916
ENSP00000377977L753FHPILeukemia8358735 8316249 10766198 8938150 8895760 7812967
ENSP00000231509E279QCOSMICHead and Neck Cancer21798893
ENSP00000231509M605ICOSMICOvarian Cancer21720365
ENSP00000231509G91ECOSMICSkin Cancer21984974

Differential expressed protein
GCR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GCR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANGCR_HUMANkinase -> substrateHPRD
MK08_HUMANGCR_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANGCR_HUMANkinase -> substrateRegPhos
PRKDC_HUMANGCR_HUMANkinase -> substrateHPRD
GLHA_HUMANGCR_HUMANotherKEGG
GCR_HUMANGLHA_HUMANTF -> target geneTRANSFAC
GCR_HUMANIL6_HUMANTF -> target geneTRANSFAC
GCR_HUMANIBP1_HUMANTF -> target geneTRANSFAC
RHG35_HUMANGCR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005496steroid bindingIEAmolecular_function
GO:0008211glucocorticoid metabolic processIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0043402glucocorticoid mediated signaling pathwayIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0016568chromatin modificationIEAbiological_process
GO:0042921glucocorticoid receptor signaling pathwayIEAbiological_process
GO:0060603mammary gland duct morphogenesisIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006111regulation of gluconeogenesisIEAbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0005759mitochondrial matrixTAScellular_component
GO:0005829cytosolIEAcellular_component
GO:0004883glucocorticoid receptor activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0031946regulation of glucocorticoid biosynthetic processIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function


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