Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFAC4_HUMAN
Description:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [Source:HGNC Symbol;Acc:7778]
Location:chr14 q12
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S168GGAFFsPSPGSPhosphoSitePlus
S285ASPALsRRGSLPhosphoSitePlus
T256SAPGPtPASPRPhosphoSitePlus
S676GRRKRsPTQSFRSK_groupphosphoELM
S173SPSPGsSSLSSPhosphoSitePlus
S676GRRKRsPTQSFTIGPhosphoSitePlus
S168GGAFFsPSPGSp38a(MAPK14RegPhos
S272GKRRYsSSGTPPhosphoSitePlus; phosphoELM
S532LKLRNsDIELRRHDPhosphoSitePlus
S221PSPRAsPRPWTPhosphoSitePlus; HPRD
S676GRRKRsPTQSFErk1(MAPK3RegPhos
S217GSPLPsPRASPPhosphoSitePlus; HPRD
S170AFFSPsPGSSSp38a(MAPK14RegPhos
S676GRRKRsPTQSFRSK2RegPhos
T333QKTRRtSSEQAPhosphoSitePlus
S334KTRRTsSEQAVPhosphoSitePlus; phosphoELM
Y234DPWSLyGPSPGPhosphoSitePlus; HPRD
S168GGAFFsPSPGSMAPK14HPRD; phosphoELM
S335TRRTSsEQAVAPhosphoSitePlus; phosphoELM
S654TVPEYsNKRVSTIGPhosphoSitePlus
S213RFGLGsPLPSPPhosphoSitePlus; HPRD
S168GGAFFsPSPGSp38aRegPhos
S264SPRPAsPCGKRPhosphoSitePlus
Y653LTVPEySNKRVTIGPhosphoSitePlus
S281TPSSAsPALSRPhosphoSitePlus
S676GRRKRsPTQSFRSK-2phosphoELM
S246RGPEDsWLLLSPhosphoSitePlus
S237SLYGPsPGGRGPhosphoSitePlus
S344VALPRsEEPASPhosphoSitePlus
S676GRRKRsPTQSFMAPK3phosphoELM
S170AFFSPsPGSSSPhosphoSitePlus
S170AFFSPsPGSSSMAPK14HPRD; phosphoELM
S676GRRKRsPTQSFErk2(MAPK1RegPhos
S289LSRRGsLGEEGPhosphoSitePlus; HPRD; RegPhos; SysPTM
T226SPRPWtPEDPWPhosphoSitePlus
S676GRRKRsPTQSFMAPK1phosphoELM
S170AFFSPsPGSSSp38aRegPhos

Dephosphorylation site
NFAC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000250373E739KCOSMICMelanoma21499247
ENSP00000388910P125HTCGAOvarian Cancer21720365, 18772890
ENSP00000250373P62HCOSMICOvarian Cancer21720365
ENSP00000250373G357ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000250373P304LCOSMICSkin Cancer21984974

Differential expressed protein
NFAC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFAC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK36_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
TRIB3_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
EPHB1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
IGF1R_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANNFAC4_HUMANkinase -> substrateRegPhos
ITK_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
VRK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
DCLK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNFAC4_HUMANkinase -> substrateKEGG
SLTM_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANNFAC4_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
STK38_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANNFAC4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PXK_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
UHMK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CHP1_HUMANNFAC4_HUMANphosphatase -> substrateKEGG
NFAC4_HUMANPPARG_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04010MAPK signaling pathway
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0034644cellular response to UVIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045333cellular respirationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0055001muscle cell developmentIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function