Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACV1B_HUMAN
Description:activin A receptor, type IB [Source:HGNC Symbol;Acc:172]
Location:chr12 q13.13
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y380VGTKRyMAPEVPkinasePhosphoSitePlus
Y184LQDLVyDLSTSTGF_beta_GSPhosphoSitePlus
Y380VGTKRyMAPEVHPRD
Y156YHQRVyHNRQRPhosphoSitePlus

Dephosphorylation site
ACV1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000390477V203MBIOMARTBreast Cancer21930507, 21930502
ENSP00000390477D402EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000257963W275*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000397550G214VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000442656R485*COSMICBreast Cancer20668451
ENSP00000257963G214VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000390477G214VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000257963D402EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000397550V203MBIOMARTBreast Cancer21930507, 21930502
ENSP00000257963V203MBIOMARTBreast Cancer21930507, 21930502
ENSP00000397550D402EBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
ACV1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACV1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INHBA_HUMANACV1B_HUMANligand -> receptorHPMR
NODAL_HUMANACV1B_HUMANligand -> receptorHPMR
ACV1B_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANSMAD2_HUMANkinase -> substrateRegPhos
ACV1B_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034711inhibin bindingIPImolecular_function
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:1901165positive regulation of trophoblast cell migrationIDAbiological_process
GO:0038092nodal signaling pathwayIGIbiological_process
GO:0006917induction of apoptosisIMPbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0046545development of primary female sexual characteristiIEAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0045648positive regulation of erythrocyte differentiationIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0023014signal transduction by phosphorylationIEAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0032924activin receptor signaling pathwayIDAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process
GO:0032927positive regulation of activin receptor signaling IDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0007178transmembrane receptor protein serine/threonine kiTASbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0007165signal transductionIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0016361activin receptor activity, type ITASmolecular_function
GO:0048185activin bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0009966regulation of signal transductionIEAbiological_process
GO:0019838growth factor bindingIPImolecular_function
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0004675transmembrane receptor protein serine/threonine kiNASmolecular_function
GO:0017002activin-activated receptor activityIDAmolecular_function