Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK12_HUMAN
Description:mitogen-activated protein kinase 12 [Source:HGNC Symbol;Acc:6874]
Location:chr22 q13.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y185SEMTGyVVTRWPkinasePhosphoSitePlus
S180ARQADsEMTGYPkinasePhosphoSitePlus
S3___MSsPPPARPhosphoSitePlus
S3MSSPPpARp38gRegPhos
Y27EVRAVyRDLQPHPRD; phosphoELM; RegPhos; SysPTM
Y185SEMTGyVVTRWHPRD; phosphoELM; RegPhos
T183ADSEMtGYVVTMAP2K3HPRD; phosphoELM; RegPhos
T183ADSEMtGYVVTMAP2K6HPRD; phosphoELM; RegPhos
T183ADSEMtGYVVTPkinasePhosphoSitePlus
T183ADSEMtGYVVTRegPhos
S3MSSPPpARp38g(MAPK12RegPhos
Y185SEMTGyVVTRWMAP2K3phosphoELM; RegPhos
Y185SEMTGyVVTRWMAP2K4HPRD; phosphoELM; RegPhos
Y185SEMTGyVVTRWMAP2K6phosphoELM; RegPhos
S3PPARMAPK12HPRD; phosphoELM

Dephosphorylation site
MK12_HUMAN do not have dephosphorylation site.

Mutation site
MK12_HUMAN do not have mutation site.

Differential expressed protein
MK12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y185PkinaseADSEMTGyVVTRWYRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MP2K4_HUMANMK12_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CDK5_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MK12_HUMANMK12_HUMANkinase -> substrateHPRD
MK12_HUMAN3BP5_HUMANkinase -> substrateHPRD
MAPK5_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK12_HUMANkinase -> substrateRegPhos
KSYK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MP2K3_HUMANMK12_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK12_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MK12_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANMK12_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
AAPK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MK12_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MK12_HUMANEF2K_HUMANkinase -> substrateHPRD
MK12_HUMANTAU_HUMANkinase -> substrateHPRD
MK08_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
MK12_HUMANSNTA1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK12_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04728Dopaminergic synapse
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04914Progesterone-mediated oocyte maturation
hsa04912GnRH signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04010MAPK signaling pathway
hsa05169Epstein-Barr virus infection
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa05133Pertussis
hsa04370VEGF signaling pathway
hsa05152Tuberculosis
hsa05140Leishmaniasis
hsa04722Neurotrophin signaling pathway
hsa05132Salmonella infection
hsa05131Shigellosis
hsa05164Influenza A
hsa05142Chagas disease (American trypanosomiasis)
hsa04380Osteoclast differentiation
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04664Fc epsilon RI signaling pathway
hsa04114Oocyte meiosis
hsa04621NOD-like receptor signaling pathway
hsa05160Hepatitis C
hsa05145Toxoplasmosis
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0007517muscle organ developmentTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042692muscle cell differentiationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0000165MAPK cascadeIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006975DNA damage induced protein phosphorylationTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0045445myoblast differentiationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0007050cell cycle arrestTASbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function