Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHOA_HUMAN
Description:ras homolog family member A [Source:HGNC Symbol;Acc:667]
Location:chr3 p21.31
Node attribute:PPI(source); substrate; effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y156IGAFGyMECSARasPhosphoSitePlus
Y66AGQEDyDRLRPRasPhosphoSitePlus
S188RGKKKsGCLVLPhosphoSitePlus
S188RGKKKsGCLVLPKA_groupRegPhos
S188RGKKKsGCLPKA_groupphosphoELM
Y34QFPEVyVPTVFRasPhosphoSitePlus
S188RGKKKsGCLPRKACAHPRD
S188RGKKKsGCLVLPKACaRegPhos

Dephosphorylation site
RHOA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000400175D76NCOSMICOvarian Cancer21720365
ENSP00000400175G17VCOSMICOvarian Cancer21720365
ENSP00000400175E40QCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000400175Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueUp17593366
ENSP00000400175Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.219120023
ENSP00000400175Gastric CancerMetastasiscell lineDown0.3517022644

Hyperphosphorylation site
RHOA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB1_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG1_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG12_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBB3_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG2_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG10_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG3_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBB5_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG5_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG8_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG13_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBG11_HUMANRHOA_HUMANGprotein -> effectorgpDB
KPCA_HUMANRHOA_HUMANkinase -> substrateHPRD
RHOA_HUMANML12B_HUMANotherKEGG
RHOA_HUMANROCK1_HUMANotherKEGG
RHOA_HUMANRAC1_HUMANotherKEGG
TGFR2_HUMANRHOA_HUMANotherKEGG
RHOA_HUMANDIAP1_HUMANotherKEGG
VAV3_HUMANRHOA_HUMANotherKEGG
RGRF1_HUMANRHOA_HUMANotherKEGG
RHG35_HUMANRHOA_HUMANotherKEGG
RHOA_HUMANPI51C_HUMANotherKEGG
GNDS_HUMANRHOA_HUMANotherKEGG
ARHGC_HUMANRHOA_HUMANotherKEGG
RHOA_HUMANMK08_HUMANotherKEGG
RHOA_HUMANDAAM1_HUMANotherKEGG
KPCA_HUMANRHOA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa05200Pathways in cancer
hsa04520Adherens junction
hsa04360Axon guidance
hsa04350TGF-beta signaling pathway
hsa05152Tuberculosis
hsa05133Pertussis
hsa05203Viral carcinogenesis
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04660T cell receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa04310Wnt signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04972Pancreatic secretion
hsa05210Colorectal cancer
hsa04530Tight junction
hsa04144Endocytosis
hsa04722Neurotrophin signaling pathway
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043296apical junction complexIDAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0008064regulation of actin polymerization or depolymerizaIEAbiological_process
GO:0061383trabecula morphogenesisIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0043149stress fiber assemblyIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0001666response to hypoxiaIEAbiological_process
GO:0045666positive regulation of neuron differentiationIMPbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0071803positive regulation of podosome assemblyIEAbiological_process
GO:0030496midbodyIEAcellular_component
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0050772positive regulation of axonogenesisTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0050771negative regulation of axonogenesisTASbiological_process
GO:0043931ossification involved in bone maturationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0031098stress-activated protein kinase signaling cascadeIEAbiological_process
GO:0050773regulation of dendrite developmentIEAbiological_process
GO:0051496positive regulation of stress fiber assemblyIDAbiological_process
GO:0030054cell junctionTAScellular_component
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0033688regulation of osteoblast proliferationIEAbiological_process
GO:0017022myosin bindingIPImolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0090307spindle assembly involved in mitosisIMPbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0050770regulation of axonogenesisTASbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0032154cleavage furrowIEAcellular_component
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0036089cleavage furrow formationIDAbiological_process
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0033144negative regulation of intracellular steroid hormoIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045727positive regulation of translationIEAbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0043297apical junction assemblyIEAbiological_process
GO:0030334regulation of cell migrationIMPbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042346positive regulation of NF-kappaB import into nucleNASbiological_process
GO:0005938cell cortexIDAcellular_component
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0030521androgen receptor signaling pathwayIEAbiological_process