Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ASAP2_HUMAN
Description:ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [Source:HGNC Symbol;Acc:2721]
Location:chr2 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T900GADKStPLTNKPhosphoSitePlus
S722EDRPIsFYQLGPhosphoSitePlus
S338GFLTIsHGTANPHPhosphoSitePlus
S294QSTAYsLHQPQPhosphoSitePlus
T903KSTPLtNKGQPPhosphoSitePlus
S701EDLDEsDDDMDPhosphoSitePlus; HPRD; phosphoELM
S329QKRKCsVKNGFPHPhosphoSitePlus
S728FYQLGsNQLQSPhosphoSitePlus
Y201LQMCEyLLKVNGLTPPhosphoSitePlus
Y689HVHVEyEWRLLPhosphoSitePlus
T336KNGFLtISHGTPHPhosphoSitePlus
Y293RQSTAySLHQPPhosphoSitePlus
S822RQRSSsDPPAVPhosphoSitePlus; HPRD; phosphoELM
S809LWKTNsVSVDGPhosphoSitePlus
S820GSRQRsSSDPPPhosphoSitePlus
T556CEAVKtRDIFGPhosphoSitePlus
Y763LQNETyGALLSPhosphoSitePlus
Y724RPISFyQLGSNPhosphoSitePlus

Dephosphorylation site
ASAP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281419S294NCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000281419LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineDown17449014

Hyperphosphorylation site
ASAP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GRK5_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
NEK10_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ASAP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0008047enzyme activator activityTASmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0032312regulation of ARF GTPase activityIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043085positive regulation of catalytic activityTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function


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