Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SENP1_HUMAN
Description:SUMO1/sentrin specific peptidase 1 [Source:HGNC Symbol;Acc:17927]
Location:chr12 q13.11
Node attribute:substrate; desumoylation(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S126ETRKTsSGLSNPhosphoSitePlus
S80NPSSDsFLGSGPhosphoSitePlus
S180QRRHVsTAEETPhosphoSitePlus
Y349ELTSVyDSRARPhosphoSitePlus
T330DSQTPtPSSTFPhosphoSitePlus
S132SGLSNsFAGKSPhosphoSitePlus
T414KGHKLtDSEDEPhosphoSitePlus
S170RRSLLsPKKTQPhosphoSitePlus
S78SDNPSsDSFLGPhosphoSitePlus
T102QWRNStPSSSSPhosphoSitePlus
T328VKDSQtPTPSSPhosphoSitePlus
S149SAYEKsFPIKPPhosphoSitePlus
S157IKPVPsPSWSGPhosphoSitePlus; phosphoELM

Dephosphorylation site
SENP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000394791D468YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000394791I4TCOSMICLung Cancer20668451
ENSP00000004980D468YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000450076I4TCOSMICLung Cancer20668451

Differential expressed protein
SENP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SENP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANSENP1_HUMANkinase -> substrateNetPath
SENP1_HUMANHDAC1_HUMANdesumoylationNetPath

Function Annotation
KEGG Pathway
SENP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016926protein desumoylationIEAbiological_process
GO:0004175endopeptidase activityTASmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0032435negative regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIGIbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0008234cysteine-type peptidase activityIEAmolecular_function
GO:0010724regulation of definitive erythrocyte differentiatiIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0097190apoptotic signaling pathwayIMPbiological_process
GO:0016929SUMO-specific protease activityIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23