| UniProt/SwissProt ID: | SENP1_HUMAN |
| Description: | SUMO1/sentrin specific peptidase 1 [Source:HGNC Symbol;Acc:17927] |
| Location: | chr12 q13.11 |
| Node attribute: | substrate; desumoylation(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S126 | ETRKTsSGLSN | PhosphoSitePlus | |
| S80 | NPSSDsFLGSG | PhosphoSitePlus | |
| S180 | QRRHVsTAEET | PhosphoSitePlus | |
| Y349 | ELTSVyDSRAR | PhosphoSitePlus | |
| T330 | DSQTPtPSSTF | PhosphoSitePlus | |
| S132 | SGLSNsFAGKS | PhosphoSitePlus | |
| T414 | KGHKLtDSEDE | PhosphoSitePlus | |
| S170 | RRSLLsPKKTQ | PhosphoSitePlus | |
| S78 | SDNPSsDSFLG | PhosphoSitePlus | |
| T102 | QWRNStPSSSS | PhosphoSitePlus | |
| T328 | VKDSQtPTPSS | PhosphoSitePlus | |
| S149 | SAYEKsFPIKP | PhosphoSitePlus | |
| S157 | IKPVPsPSWSG | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| SENP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000394791 | D468Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000394791 | I4T | COSMIC | Lung Cancer | 20668451 | ENSP00000004980 | D468Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000450076 | I4T | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| SENP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SENP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | SENP1_HUMAN | kinase -> substrate | NetPath |
| SENP1_HUMAN | HDAC1_HUMAN | desumoylation | NetPath |
| Function Annotation |
| KEGG Pathway |
| SENP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016926 | protein desumoylation | IEA | biological_process |
| GO:0004175 | endopeptidase activity | TAS | molecular_function |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0032435 | negative regulation of proteasomal ubiquitin-depen | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IGI | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | IMP | biological_process |
| GO:0008234 | cysteine-type peptidase activity | IEA | molecular_function |
| GO:0010724 | regulation of definitive erythrocyte differentiati | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0097190 | apoptotic signaling pathway | IMP | biological_process |
| GO:0016929 | SUMO-specific protease activity | IEA | molecular_function |