Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD4_HUMAN
Description:SMAD family member 4 [Source:HGNC Symbol;Acc:6770]
Location:chr18 q21.2
Node attribute:PPI(source); PPI(target); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S343TFKVPsSCPIVMH2PhosphoSitePlus
T77VTIQRtLDGRLMH1PhosphoSitePlus
S504CILRMsFVKGWMH2PhosphoSitePlus
T277RTAPYtPNLPHMAPK1HPRD
T277RTAPYtPNLPHMAPK3phosphoELM
S22LSIVHsLMCHRPhosphoSitePlus
T9MSITNtPTSNDPhosphoSitePlus
T277RTAPYtPNLPHErk1(MAPK3RegPhos
S138YERVVsPGIDLPhosphoSitePlus
T277RTAPYtPNLPHErk2RegPhos
Y95FPHVIyARLWRMH1PhosphoSitePlus
S32RQGGEsETFAKPhosphoSitePlus

Dephosphorylation site
SMAD4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381452A274EDing2008, COSMICLung Cancer18948947
ENSP00000381452R515fs*22COSMICPancreatic Cancer
ENSP00000381452C363RCOSMICPancreatic Cancer18772397
ENSP00000341551S432GCOSMICThyroid Carcinoma15940269
ENSP00000341551V539GCOSMICPancreatic Cancer17436386
ENSP00000381452D351HDing2008Pancreatic Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000381452D351NHPIColorectal Cancer16959974
ENSP00000381452H317QCOSMICThyroid Carcinoma15940269
ENSP00000381452G86VCOSMICPancreatic Cancer18772397
ENSP00000381452Q116*COSMICPancreatic Cancer
ENSP00000341551N263SCOSMICThyroid Carcinoma15940269
ENSP00000381452I527VCOSMICThyroid Carcinoma15940269
ENSP00000381452D493HOMIM, COSMIC, HPIPancreatic Cancer8653691, 18772397, 8553070 17994767
ENSP00000381452E538*COSMICIntestines Cancer10479724
ENSP00000381452Y195fs*1COSMICPancreatic Cancer9892110
ENSP00000341551Y95SCOSMICPancreatic Cancer
ENSP00000341551R515fs*22COSMICPancreatic Cancer
ENSP00000341551E526*COSMICHead and Neck Cancer8653689
ENSP00000381452I383KCOSMICPancreatic Cancer11040453
ENSP00000341551P550SCOSMICThyroid Carcinoma15940269
ENSP00000341551I326fs*10COSMICIntestines Cancer10479724
ENSP00000381452E330*COSMICIntestines Cancer
ENSP00000381452D351NSjoblom2006Intestines Cancer16959974
ENSP00000341551C115RCOSMICIntestines Cancer10340381
ENSP00000381452E526*COSMICHead and Neck Cancer8653689
ENSP00000341551Q534fs*3COSMICPancreatic Cancer
ENSP00000341551W268fs*0COSMICPancreatic Cancer
ENSP00000341551V44GBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551R531WCOSMICIntestines Cancer17167985
ENSP00000381452Y276*Ding2008, COSMICLung Cancer18948947
ENSP00000341551I527VCOSMICThyroid Carcinoma15940269
ENSP00000341551Y412*COSMICPancreatic Cancer18772397
ENSP00000341551G491VCOSMICIntestines Cancer15814640
ENSP00000381452Q245*COSMICPancreatic Cancer15014009
ENSP00000341551D351NSjoblom2006Intestines Cancer16959974
ENSP00000381452G247ECOSMICIntestines Cancer19527492
ENSP00000341551P203LCOSMICThyroid Carcinoma15940269
ENSP00000381452E330QCOSMICIntestines Cancer11196171
ENSP00000381452V128MCOSMICThyroid Carcinoma15940269
ENSP00000341551R515*COSMICPancreatic Cancer8553070
ENSP00000341551H262RCOSMICLung Cancer20668451
ENSP00000341551H317QCOSMICThyroid Carcinoma15940269
ENSP00000381452L533VCOSMICIntestines Cancer15814640
ENSP00000341551V126ACOSMICPancreatic Cancer15014009
ENSP00000341551A406TCOSMICPancreatic Cancer9892110
ENSP00000341551L536QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452S343*COSMICPancreatic Cancer8653691
ENSP00000341551G30*COSMICLung Cancer
ENSP00000381452N369DCOSMICPancreatic Cancer10327057
ENSP00000341551D494GCOSMICPancreatic Cancer
ENSP00000381452Q311*COSMICIntestines Cancer11481457
ENSP00000381452R416SCOSMICIntestines Cancer12569386
ENSP00000381452Q516*COSMICIntestines Cancer9155588
ENSP00000381452Y322*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452S432GCOSMICThyroid Carcinoma15940269
ENSP00000341551M331TCOSMICThyroid Carcinoma15940269
ENSP00000381452R515*COSMICPancreatic Cancer8553070
ENSP00000381452V126ACOSMICPancreatic Cancer15014009
ENSP00000341551Y328*COSMICPancreatic Cancer15014009
ENSP00000381452F339SCOSMICThyroid Carcinoma15940269
ENSP00000341551F408SCOSMICIntestines Cancer11172591
ENSP00000381452V44GBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452W99RCOSMICPancreatic Cancer15014009
ENSP00000341551W524CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551S343*COSMICPancreatic Cancer8653691
ENSP00000381452R100TCOSMICPancreatic Cancer8653691
ENSP00000381452C25YCOSMICIntestines Cancer19527492
ENSP00000381452R445*COSMICPancreatic Cancer18772397
ENSP00000381452R502GCOSMICBiliary Tract Cancer9515793
ENSP00000341551Y353CCOSMICIntestines Cancer15014009
ENSP00000341551R445*COSMICPancreatic Cancer18772397
ENSP00000341551P356LCOSMICIntestines Cancer14647445
ENSP00000381452I314NCOSMICThyroid Carcinoma15940269
ENSP00000381452D351HDing2008Intestines Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000341551L540RCOSMICIntestines Cancer11481457
ENSP00000341551E538*COSMICIntestines Cancer10479724
ENSP00000341551I383KCOSMICPancreatic Cancer11040453
ENSP00000381452D332GCOSMICHepatocellular Carcinoma10490821
ENSP00000381452Q334*COSMICGastric Cancer9331080
ENSP00000341551D355ACOSMICIntestines Cancer11196171
ENSP00000381452K507QCOSMICIntestines Cancer10340381
ENSP00000381452R531WCOSMICIntestines Cancer17167985
ENSP00000341551P130LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452M331TCOSMICThyroid Carcinoma15940269
ENSP00000341551Q116*COSMICPancreatic Cancer
ENSP00000341551Q239*COSMICIntestines Cancer11481457
ENSP00000381452Y412*COSMICPancreatic Cancer18772397
ENSP00000341551G86VCOSMICPancreatic Cancer18772397
ENSP00000381452L540RCOSMICIntestines Cancer11481457
ENSP00000341551A226TCOSMICThyroid Carcinoma15940269
ENSP00000381452D355ACOSMICIntestines Cancer11196171
ENSP00000341551Q83*COSMICPancreatic Cancer
ENSP00000341551K340ECOSMICIntestines Cancer8898652
ENSP00000341551R135*COSMICPancreatic Cancer18772397
ENSP00000381452P130SHPIColorectal Cancer16959974
ENSP00000341551W99RCOSMICPancreatic Cancer15014009
ENSP00000341551H132LCOSMICIntestines Cancer11791187
ENSP00000341551N129KCOSMICIntestines Cancer10479724
ENSP00000341551E330*COSMICIntestines Cancer
ENSP00000381452V492FCOSMICBiliary Tract Cancer15014009
ENSP00000381452P130SSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000381452C324YCOSMICThyroid Carcinoma15940269
ENSP00000381452Y95SCOSMICPancreatic Cancer
ENSP00000341551Q334*COSMICGastric Cancer9331080
ENSP00000341551D351HDing2008Pancreatic Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000381452P550SCOSMICThyroid Carcinoma15940269
ENSP00000341551S504RCOSMICOvarian Cancer10451707
ENSP00000381452Y131CCOSMICPancreatic Cancer
ENSP00000341551A433VCOSMICIntestines Cancer11172591
ENSP00000381452R361HSjoblom2006Intestines Cancer10340381, 16959974, 18428421
ENSP00000381452W509*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000341551Y195fs*1COSMICPancreatic Cancer9892110
ENSP00000341551G247ECOSMICIntestines Cancer19527492
ENSP00000381452Q534fs*3COSMICPancreatic Cancer
ENSP00000381452G168*COSMICIntestines Cancer10340381
ENSP00000381452F408SCOSMICIntestines Cancer11172591
ENSP00000341551Q516*COSMICIntestines Cancer9155588
ENSP00000381452V539GCOSMICPancreatic Cancer17436386
ENSP00000341551C523WCOSMICPancreatic Cancer11161385
ENSP00000341551Y322*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551R497HCOSMICIntestines Cancer10340381
ENSP00000381452R135*COSMICPancreatic Cancer18772397
ENSP00000341551W302RCOSMICIntestines Cancer11172591
ENSP00000341551R361HSjoblom2006Intestines Cancer10340381, 16959974, 18428421, 21930507, 21930502
ENSP00000341551Y276*Ding2008, COSMICLung Cancer18948947
ENSP00000341551C324YCOSMICThyroid Carcinoma15940269
ENSP00000381452G491VCOSMICIntestines Cancer15814640
ENSP00000341551D351HDing2008Lung Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000381452A118VCOSMICPancreatic Cancer18772397
ENSP00000381452W268fs*0COSMICPancreatic Cancer
ENSP00000381452W524CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551D351HDing2008Intestines Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000381452I326fs*10COSMICIntestines Cancer10479724
ENSP00000341551A118VCOSMICPancreatic Cancer18772397
ENSP00000341551C499YCOSMICPancreatic Cancer18772397
ENSP00000381452C523WCOSMICPancreatic Cancer11161385
ENSP00000341551R420HCOSMICLung Cancer8665501
ENSP00000341551K507QCOSMICIntestines Cancer10340381
ENSP00000341551I314NCOSMICThyroid Carcinoma15940269
ENSP00000381452S144*COSMICSkin Cancer
ENSP00000341551G386RCOSMICIntestines Cancer10698524
ENSP00000341551A274EDing2008, COSMICLung Cancer18948947
ENSP00000341551D351NHPIColorectal Cancer16959974
ENSP00000381452W509*COSMICCentral Nervous System Neoplasms18772890
ENSP00000381452Q83*COSMICPancreatic Cancer
ENSP00000381452A406TCOSMICPancreatic Cancer9892110
ENSP00000381452C115RCOSMICIntestines Cancer10340381
ENSP00000341551C401RCOSMICHepatocellular Carcinoma10490821
ENSP00000341551R361CCOSMICIntestines Cancer15014009
ENSP00000341551E526VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551R416SCOSMICIntestines Cancer12569386
ENSP00000341551V350DCOSMICIntestines Cancer8898652
ENSP00000341551L54SCOSMICIntestines Cancer19527492
ENSP00000341551R361HBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000381452R420HCOSMICLung Cancer8665501
ENSP00000381452D351HDing2008, COSMICOvarian Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000341551C25YCOSMICIntestines Cancer19527492
ENSP00000381452N263SCOSMICThyroid Carcinoma15940269
ENSP00000341551R496HCOSMICThyroid Carcinoma15940269
ENSP00000341551D351HDing2008, COSMICOvarian Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000381452R361CCOSMICIntestines Cancer15014009
ENSP00000381452Q366*COSMICPancreatic Cancer18772397
ENSP00000341551P102LCOSMICLymphoma11244507
ENSP00000341551R441PCOSMICLung Cancer8665501
ENSP00000381452K340ECOSMICIntestines Cancer8898652
ENSP00000381452S504RCOSMICOvarian Cancer10451707
ENSP00000341551F339SCOSMICThyroid Carcinoma15940269
ENSP00000381452G358*COSMICPancreatic Cancer18772397
ENSP00000341551C363RCOSMICPancreatic Cancer18772397
ENSP00000341551V128MCOSMICThyroid Carcinoma15940269
ENSP00000341551N369DCOSMICPancreatic Cancer10327057
ENSP00000341551Q256*COSMICHead and Neck Cancer
ENSP00000341551D332GCOSMICHepatocellular Carcinoma10490821
ENSP00000381452E526VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452R497HCOSMICIntestines Cancer10340381
ENSP00000381452Y195*COSMICIntestines Cancer10340381
ENSP00000381452R76ICOSMICIntestines Cancer19527492
ENSP00000381452W302RCOSMICIntestines Cancer11172591
ENSP00000341551A457SCOSMICPancreatic Cancer10327057
ENSP00000381452G386RCOSMICIntestines Cancer10698524
ENSP00000341551S144*COSMICSkin Cancer
ENSP00000341551R100TCOSMICPancreatic Cancer8653691
ENSP00000381452A457SCOSMICPancreatic Cancer10327057
ENSP00000341551P130SHPIColorectal Cancer16959974
ENSP00000381452A433VCOSMICIntestines Cancer11172591
ENSP00000341551Q366*COSMICPancreatic Cancer18772397
ENSP00000341551L43SCOSMICPancreatic Cancer9892110
ENSP00000341551P130SSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000381452F310LBIOMARTBreast Cancer21930507, 21930502
ENSP00000341551E330QCOSMICIntestines Cancer11196171
ENSP00000381452A226TCOSMICThyroid Carcinoma15940269
ENSP00000381452A379TCOSMICOvarian Cancer10451707
ENSP00000381452V350DCOSMICIntestines Cancer8898652
ENSP00000381452Q248*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452N129KCOSMICIntestines Cancer10479724
ENSP00000381452Q239*COSMICIntestines Cancer11481457
ENSP00000341551F310LBIOMARTBreast Cancer21930507, 21930502
ENSP00000381452L54SCOSMICIntestines Cancer19527492
ENSP00000381452V506MCOSMICIntestines Cancer14647445
ENSP00000341551D493HOMIM, COSMIC, HPIPancreatic Cancer8653691, 18772397, 8553070 17994767
ENSP00000381452C499YCOSMICPancreatic Cancer18772397
ENSP00000341551R76ICOSMICIntestines Cancer19527492
ENSP00000341551W509*COSMICCentral Nervous System Neoplasms18772890
ENSP00000381452R441PCOSMICLung Cancer8665501
ENSP00000381452L57*COSMICGastric Cancer20682711
ENSP00000341551A379TCOSMICOvarian Cancer10451707
ENSP00000381452D494GCOSMICPancreatic Cancer
ENSP00000381452Q256*COSMICHead and Neck Cancer
ENSP00000341551V492FCOSMICBiliary Tract Cancer15014009
ENSP00000381452C401RCOSMICHepatocellular Carcinoma10490821
ENSP00000381452G30*COSMICLung Cancer
ENSP00000341551D537YCOSMICIntestines Cancer11481457
ENSP00000381452R361HHPIColorectal Cancer16959974
ENSP00000381452L43SCOSMICPancreatic Cancer9892110
ENSP00000341551Y195*COSMICIntestines Cancer10340381
ENSP00000341551G358*COSMICPancreatic Cancer18772397
ENSP00000341551Q245*COSMICPancreatic Cancer15014009
ENSP00000341551A39TCOSMICIntestines Cancer19527492
ENSP00000381452A39TCOSMICIntestines Cancer19527492
ENSP00000381452D537YCOSMICIntestines Cancer11481457
ENSP00000341551Y131CCOSMICPancreatic Cancer
ENSP00000381452H262RCOSMICLung Cancer20668451
ENSP00000381452Y353CCOSMICIntestines Cancer15014009
ENSP00000341551L57*COSMICGastric Cancer20682711
ENSP00000381452D351HDing2008Lung Cancer10451707, 11040453, 11481457, 18428421, 18948947, 8653691, 9285566
ENSP00000341551R502GCOSMICBiliary Tract Cancer9515793
ENSP00000381452P203LCOSMICThyroid Carcinoma15940269
ENSP00000341551V506MCOSMICIntestines Cancer14647445
ENSP00000381452P102LCOSMICLymphoma11244507
ENSP00000381452P356LCOSMICIntestines Cancer14647445
ENSP00000341551Q311*COSMICIntestines Cancer11481457
ENSP00000341551W509*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000381452R496HCOSMICThyroid Carcinoma15940269
ENSP00000341551G168*COSMICIntestines Cancer10340381
ENSP00000381452Y328*COSMICPancreatic Cancer15014009
ENSP00000381452L536QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381452P130LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341551L533VCOSMICIntestines Cancer15814640
ENSP00000381452H132LCOSMICIntestines Cancer11791187
ENSP00000341551Q248*BIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
SMAD4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMAD4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
YES_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
M3K11_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
RAGE_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANSMAD4_HUMANkinase -> substrateHPRD
MK09_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
SMAD2_HUMANSMAD4_HUMANotherKEGG
SMAD1_HUMANSMAD4_HUMANotherKEGG
SMAD4_HUMANLEF1_HUMANotherKEGG
SMAD4_HUMANPAI1_HUMANTF -> target geneTRANSFAC
SMAD4_HUMANJUN_HUMANTF -> target geneTRANSFAC
SMAD4_HUMANMMP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa05220Chronic myeloid leukemia
hsa04520Adherens junction
hsa05200Pathways in cancer
hsa05212Pancreatic cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032525somite rostral/caudal axis specificationIEAbiological_process
GO:0032909regulation of transforming growth factor beta2 proIMPbiological_process
GO:0072133metanephric mesenchyme morphogenesisIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0048729tissue morphogenesisIEAbiological_process
GO:0071141SMAD protein complexIDAcellular_component
GO:0042803protein homodimerization activityIPImolecular_function
GO:0060021palate developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0042177negative regulation of protein catabolic processIMPbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0048733sebaceous gland developmentIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0030511positive regulation of transforming growth factor IDAbiological_process
GO:0060391positive regulation of SMAD protein import into nuIEAbiological_process
GO:0072134nephrogenic mesenchyme morphogenesisIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0048589developmental growthIEAbiological_process
GO:0030616transforming growth factor beta receptor, common-pIDAmolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0060391positive regulation of SMAD protein import into nuISSbiological_process
GO:0060021palate developmentISSbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0000988protein binding transcription factor activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0005518collagen bindingIEAmolecular_function
GO:0032444activin responsive factor complexIDAcellular_component
GO:0051098regulation of bindingIEAbiological_process
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0048859formation of anatomical boundaryIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0014033neural crest cell differentiationIEAbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIDAmolecular_function
GO:0001666response to hypoxiaIMPbiological_process
GO:0030513positive regulation of BMP signaling pathwayIMPbiological_process
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0017015regulation of transforming growth factor beta receIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007498mesoderm developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0071559response to transforming growth factor beta stimulIDAbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tISSbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0051797regulation of hair follicle developmentIEAbiological_process