Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPARA_HUMAN
Description:peroxisome proliferator-activated receptor alpha [Source:HGNC Symbol;Acc:9232]
Location:chr22 q13.31
Node attribute:TF; PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S21AGDLEsPLSEEMAPK1HPRD
S12PLCPLsPLEAGMAPK_groupphosphoELM; RegPhos
S21AGDLEsPLSEEMAPK_groupphosphoELM; RegPhos
S21AGDLEsPLSEEMAPK3HPRD
S21AGDLEsPLSEEErk2RegPhos
S12PLCPLsPLEAGMAPK1HPRD
S12PLCPLsPLEAGMAPK3HPRD
S12PLCPLsPLEAGErk1RegPhos
S12PLCPLsPLEAGErk2RegPhos
S230ARVILsGKASNPhosphoSitePlus
S21AGDLEsPLSEEPhosphoSitePlus
S12PLCPLsPLEAGPhosphoSitePlus
S21AGDLEsPLSEEErk1RegPhos
S6MVDTEsPLCPLPhosphoSitePlus
S179GRMPRsEKAKLPhosphoSitePlus

Dephosphorylation site
PPARA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379322G58ACOSMICOvarian Cancer21720365
ENSP00000262735E20QCOSMICHead and Neck Cancer21798893
ENSP00000262735R172CCOSMICSkin Cancer21984974
ENSP00000262735DR140DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385523E20QCOSMICHead and Neck Cancer21798893
ENSP00000385246E20QCOSMICHead and Neck Cancer21798893
ENSP00000385246DR140DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385246R172CCOSMICSkin Cancer21984974
ENSP00000262735G58ACOSMICOvarian Cancer21720365
ENSP00000379322G58ATCGAOvarian Cancer21720365, 18772890
ENSP00000379322DR140DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379322R172CCOSMICSkin Cancer21984974
ENSP00000379322E20QCOSMICHead and Neck Cancer21798893
ENSP00000262735K358RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385523R172CCOSMICSkin Cancer21984974
ENSP00000385523G58ATCGAOvarian Cancer21720365, 18772890
ENSP00000385523K358RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385523DR140DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379322K358RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385246G58ACOSMICOvarian Cancer21720365
ENSP00000385246G58ATCGAOvarian Cancer21720365, 18772890
ENSP00000385523G58ACOSMICOvarian Cancer21720365
ENSP00000262735G58ATCGAOvarian Cancer21720365, 18772890
ENSP00000385246K358RCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
PPARA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPARA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANPPARA_HUMANkinase -> substrateHPRD
MK03_HUMANPPARA_HUMANkinase -> substrateHPRD
MK08_HUMANPPARA_HUMANkinase -> substrateRobert H Newman (2013)
OBRG_HUMANPPARA_HUMANotherKEGG
ADR1_HUMANPPARA_HUMANotherKEGG
PPARA_HUMANCPT1C_HUMANTF -> target geneKEGG
HNF4A_HUMANPPARA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa05160Hepatitis C
hsa03320PPAR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045820negative regulation of glycolysisICbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0032000positive regulation of fatty acid beta-oxidationTASbiological_process
GO:0072366regulation of cellular ketone metabolic process byIDAbiological_process
GO:0010887negative regulation of cholesterol storageIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0015908fatty acid transportTASbiological_process
GO:0031624ubiquitin conjugating enzyme bindingIPImolecular_function
GO:0051525NFAT protein bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006629lipid metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0042157lipoprotein metabolic processIEAbiological_process
GO:0072369regulation of lipid transport by positive regulatiIDAbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0019217regulation of fatty acid metabolic processIEAbiological_process
GO:0097371MDM2/MDM4 family protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:2000678negative regulation of transcription regulatory reIEAbiological_process
GO:1901215negative regulation of neuron deathIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0032099negative regulation of appetiteIEAbiological_process
GO:0008144drug bindingIDAmolecular_function
GO:0019902phosphatase bindingIEAmolecular_function
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0030522intracellular receptor mediated signaling pathwayIDAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0003707steroid hormone receptor activityIDAmolecular_function
GO:0010871negative regulation of receptor biosynthetic proceIDAbiological_process
GO:0072363regulation of glycolysis by positive regulation ofIDAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0004872receptor activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0035095behavioral response to nicotineIEAbiological_process
GO:0010745negative regulation of macrophage derived foam celICbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0070166enamel mineralizationIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0046321positive regulation of fatty acid oxidationIEAbiological_process
GO:0032091negative regulation of protein bindingIEAbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0010891negative regulation of sequestering of triglyceridIDAbiological_process