Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MP2K4_HUMAN
Description:mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:6844]
Location:chr17 p12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S80RLRTHsIESSGAKT_groupRegPhos
S5SGGGHPRD
S257GQLVDsIAKTRMAP2K4HPRD; phosphoELM; RegPhos
T261DSIAKtRDAGCphosphoELM
T261DSIAKtRDAGCMAP2K4HPRD; phosphoELM; RegPhos
T78IERLRtHSIESPhosphoSitePlus
S80RLRTHsIESSGPKB_groupphosphoELM
T261DSIAKtRDAGCMAP3K11phosphoELM
S80RLRTHsIESSGPhosphoSitePlus
S394PATPSsPMYVDPhosphoSitePlus
S257GQLVDsIAKTRPkinasePhosphoSitePlus
S7AAPSPsGGGGSPhosphoSitePlus
T261DSIAKtRDAGCMLK3(MAP3K11RegPhos
S90GKLKIsPEQHWPhosphoSitePlus; HPRD; phosphoELM
T56PPFKStARFTLPhosphoSitePlus
T261DSIAKtRDAGCMAP3K5phosphoELM; RegPhos
S36HPAVSsMQGKRHPRD
S26PGPVGsPAPGHHPRD
T261DSIAKtRDAGCPkinasePhosphoSitePlus
S393MPATPsSPMYHPRD
S80RLRTHsIESSGAKT1HPRD; RegPhos
S394PATPSsPMYHPRD
S5_MAAPsPSGGGPhosphoSitePlus
T391DQMPAtPSSPMHPRD

Dephosphorylation site
MP2K4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262445R154WHPIColorectal Cancer17344846
ENSP00000262445S184LBIOMARTBreast Cancer21930507, 21930502
ENSP00000262445Q142LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000262445R304*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000262445S233ABIOMARTBreast Cancer21930507, 21930502
ENSP00000410402S95*BIOMARTBreast Cancer21930507, 21930502
ENSP00000410402S244ABIOMARTBreast Cancer21930507, 21930502
ENSP00000262445V151LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000410402R292*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262445A279THPIColorectal Cancer17344846
ENSP00000262445W310*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000262445S251NGreenman2007Skin Cancer17344846, 18428421
ENSP00000410402V162LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000410402S195LBIOMARTBreast Cancer21930507, 21930502
ENSP00000262445S84*BIOMARTBreast Cancer21930507, 21930502
ENSP00000262445R110*TCGAOvarian Cancer21720365, 18772890
ENSP00000262445R281*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262445R154WGreenman2007Intestines Cancer17344846, 18428421
ENSP00000262445G303VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262445A279TGreenman2007Intestines Cancer17344846, 18428421
ENSP00000262445N234IGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
MP2K4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MP2K4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MP2K4_HUMANMK12_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
M3K5_HUMANMP2K4_HUMANkinase -> substrateRegPhos
MP2K4_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMK08_HUMANkinase -> substrateKEGG; HPRD; RegPhos; NetPath; Robert H Newman (201
MP2K4_HUMANZRAB2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANUBC9_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANRS20_HUMANkinase -> substrateRobert H Newman (2013)
M3K1_HUMANMP2K4_HUMANkinase -> substrateKEGG
MP2K4_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMK10_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
M3K11_HUMANMP2K4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K4_HUMANRXRA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K4_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMK09_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
MP2K4_HUMANMP2K4_HUMANkinase -> substrateRegPhos
MP2K4_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANMP2K4_HUMANkinase -> substrateHPRD; RegPhos
AKT3_HUMANMP2K4_HUMANkinase -> substrateKEGG
MP2K4_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANMP2K4_HUMANkinase -> substrateKEGG
PPM1A_HUMANMP2K4_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection
hsa04620Toll-like receptor signaling pathway
hsa05164Influenza A
hsa04010MAPK signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05169Epstein-Barr virus infection
hsa04012ErbB signaling pathway
hsa04912GnRH signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0007254JNK cascadeTASbiological_process
GO:0005515protein bindingIEAmolecular_function