Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JIP1_HUMAN
Description:mitogen-activated protein kinase 8 interacting protein 1 [Source:HGNC Symbol;Acc:6882]
Location:chr11 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S181TLNNNsLGKKHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T103DATGDtPGAEDJNK1(MAPK8RegPhos
T284EEIYLtPVQRPJNK1RegPhos
T241PCRRStATQMAPhosphoSitePlus
T448LSEDStPDEPDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S235GTSTDsPCRRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S444PPACLsEDSTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S197VSRSSsPLKTGJNK_groupphosphoELM; RegPhos
S195DRVSRsSSPLKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S29GLHIAsPPNFRMAPK8HPRD
S366PPPRAsLSSDTPhosphoSitePlus; phosphoELM; RegPhos
S409SDESDsATVYDPhosphoSitePlus; phosphoELM; RegPhos
S341FDCLSsPERAEJNK1RegPhos
S196RVSRSsSPLKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T103DATGDtPGAEDJNK_groupRegPhos
S340GFDCLsSPERAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T205KTGEQtPPHEHJNK1(MAPK8RegPhos
S193WQDRVsRSSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T205KTGEQtPPHEHJNK1RegPhos
T284EEIYLtPVQRPJNK_groupphosphoELM; RegPhos
S40LTHDIsLEEFEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S341FDCLSsPERAEJNK_groupphosphoELM; RegPhos
S187LGKKHsWQDRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S152SQGPGsGDTYRPhosphoSitePlus; phosphoELM; RegPhos
S197VSRSSsPLKTGMAPK8HPRD
S472GRSRSsSAESFPhosphoSitePlus; phosphoELM; RegPhos
S15GGGAAsPPAASJNK1RegPhos
T702QFVEYtCPTEDPhosphoSitePlus
S421CASVSsPYESAJNK_groupphosphoELM; RegPhos
S469FMSGRsRSSSAPhosphoSitePlus; phosphoELM; RegPhos
S421CASVSsPYESAMAPK8HPRD
S15GGGAAsPPAASPhosphoSitePlus
S341FDCLSsPERAEPhosphoSitePlus
T205KTGEQtPPHEHPhosphoSitePlus
T100DLIDAtGDTPGPhosphoSitePlus
S407DYSDEsDSATVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S355GGWRGsLGEPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S421CASVSsPYESAJNK1RegPhos
T411ESDSAtVYDNCPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S473RSRSSsAESFGPhosphoSitePlus; phosphoELM; RegPhos
S447CLSEDsTPDEPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T201SSPLKtGEQTPPhosphoSitePlus
T284EEIYLtPVQRPMAPK8HPRD
S330PHPSIsEEEEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T205KTGEQtPPHEHJNK3(MAPK10RegPhos
S29GLHIAsPPNFRJNK1RegPhos
T103DATGDtPGAEDMAPK8HPRD; phosphoELM
T103DATGDtPGAEDMAPK9phosphoELM
S328GRPHPsISEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T205KTGEQtPPHEHJNK2(MAPK9RegPhos
T103DATGDtPGAEDJNK3(MAPK10RegPhos
S29GLHIAsPPNFRJNK_groupphosphoELM; RegPhos
S197VSRSSsPLKTGJNK1RegPhos
S369RASLSsDTSALPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S214EHICLsDELPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T103DATGDtPGAEDJNK1RegPhos
S15GGGAAsPPAASJNK_groupphosphoELM; RegPhos
S240SPCRRsTATQMPhosphoSitePlus
T103DATGDtPGAEDJNK2(MAPK9RegPhos
T284EEIYLtPVQRPPhosphoSitePlus
S471SGRSRsSSAESPhosphoSitePlus; phosphoELM; RegPhos
T205KTGEQtPPHEHMAPK8HPRD
S15GGGAAsPPAASMAPK8HPRD
T205KTGEQtPPHEHJNK_groupphosphoELM; RegPhos
T103DATGDtPGAEDPhosphoSitePlus
S341FDCLSsPERAEMAPK8HPRD
S421CASVSsPYESAPhosphoSitePlus
S311RMSVSsDPDPAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T243RRSTAtQMAPPPhosphoSitePlus
S197VSRSSsPLKTGPhosphoSitePlus
S29GLHIAsPPNFRPhosphoSitePlus

Dephosphorylation site
JIP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000241014P664LCOSMICSkin Cancer21984974
ENSP00000241014M465ICOSMICMelanoma21499247
ENSP00000241014R194GBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000241014Y542CTCGAOvarian Cancer21720365, 18772890
ENSP00000241014Y542CCOSMICOvarian Cancer21720365

Differential expressed protein
JIP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
JIP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANJIP1_HUMANkinase -> substrateRegPhos
MK10_HUMANJIP1_HUMANkinase -> substrateRegPhos
MK08_HUMANJIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANJIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031966mitochondrial membraneIEAcellular_component
GO:0008432JUN kinase bindingIEAmolecular_function
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005078MAP-kinase scaffold activityIEAmolecular_function
GO:0044302dentate gyrus mossy fiberIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0046328regulation of JNK cascadeISSbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043508negative regulation of JUN kinase activityIEAbiological_process
GO:0016192vesicle-mediated transportISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0019894kinesin bindingIPImolecular_function
GO:0044295axonal growth coneIEAcellular_component
GO:0004860protein kinase inhibitor activityTASmolecular_function
GO:0030424axonIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005078MAP-kinase scaffold activityIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0046329negative regulation of JNK cascadeIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0019894kinesin bindingIEAmolecular_function
GO:0007258JUN phosphorylationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0044294dendritic growth coneIEAcellular_component
GO:0045202synapseIEAcellular_component