| UniProt/SwissProt ID: | GRK6_HUMAN |
| Description: | G protein-coupled receptor kinase 6 [Source:HGNC Symbol;Acc:4545] |
| Location: | chr5 q35.3 |
| Node attribute: | kinase; effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S111 | TQNFLsHTGPD | RGS | PhosphoSitePlus |
| Y152 | RLTHEyLSVAP | RGS | PhosphoSitePlus |
| S484 | DIEQFsTVKGV | autocatalysis | RegPhos |
| S557 | LQRLFsRQDCC | PhosphoSitePlus | |
| T485 | IEQFStVKGVE | GPRK6 | RegPhos |
| S484 | DIEQFsTVKGV | PhosphoSitePlus; phosphoELM; RegPhos | |
| T106 | CGRQLtQNFLS | RGS | PhosphoSitePlus |
| Y161 | APFADyLDSIY | RGS | PhosphoSitePlus |
| S484 | DIEQFsTVKGV | GRK6 | HPRD |
| Y166 | YLDSIyFNRFL | RGS | PhosphoSitePlus |
| T485 | IEQFStVKGVE | PhosphoSitePlus; phosphoELM; RegPhos | |
| T113 | NFLSHtGPDLI | RGS | PhosphoSitePlus |
| S484 | DIEQFsTVKGV | GPRK6 | RegPhos |
| T485 | IEQFStVKGVE | autocatalysis | RegPhos |
| T485 | IEQFStVKGVE | GRK6 | HPRD |
| Dephosphorylation site |
| GRK6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000347655 | R31Q | HPI | Gastric Cancer | 17344846 | ENSP00000347655 | I275M | HPI | breast ductal carcinoma | 17344846 |
| Differential expressed protein |
| GRK6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRK6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNA15_HUMAN | GRK6_HUMAN | Gprotein -> effector | gpDB |
| GRK6_HUMAN | GRK6_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | GRK6_HUMAN | kinase -> substrate | RegPhos |
| GRK6_HUMAN | KPCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK6_HUMAN | MK08_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK6_HUMAN | SYUA_HUMAN | kinase -> substrate | HPRD; RegPhos |
| GRK6_HUMAN | NHRF1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| GRK6_HUMAN | BKRB2_HUMAN | kinase -> substrate | RegPhos |
| GRK6_HUMAN | LT4R1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa05032 | Morphine addiction |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0008277 | regulation of G-protein coupled receptor protein s | TAS | biological_process |
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |