Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRK6_HUMAN
Description:G protein-coupled receptor kinase 6 [Source:HGNC Symbol;Acc:4545]
Location:chr5 q35.3
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S111TQNFLsHTGPDRGSPhosphoSitePlus
Y152RLTHEyLSVAPRGSPhosphoSitePlus
S484DIEQFsTVKGVautocatalysis RegPhos
S557LQRLFsRQDCCPhosphoSitePlus
T485IEQFStVKGVEGPRK6RegPhos
S484DIEQFsTVKGVPhosphoSitePlus; phosphoELM; RegPhos
T106CGRQLtQNFLSRGSPhosphoSitePlus
Y161APFADyLDSIYRGSPhosphoSitePlus
S484DIEQFsTVKGVGRK6HPRD
Y166YLDSIyFNRFLRGSPhosphoSitePlus
T485IEQFStVKGVEPhosphoSitePlus; phosphoELM; RegPhos
T113NFLSHtGPDLIRGSPhosphoSitePlus
S484DIEQFsTVKGVGPRK6RegPhos
T485IEQFStVKGVEautocatalysis RegPhos
T485IEQFStVKGVEGRK6HPRD

Dephosphorylation site
GRK6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347655R31QHPIGastric Cancer17344846
ENSP00000347655I275MHPIbreast ductal carcinoma17344846

Differential expressed protein
GRK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRK6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA15_HUMANGRK6_HUMANGprotein -> effectorgpDB
GRK6_HUMANGRK6_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANGRK6_HUMANkinase -> substrateRegPhos
GRK6_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
GRK6_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
GRK6_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
GRK6_HUMANNHRF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GRK6_HUMANBKRB2_HUMANkinase -> substrateRegPhos
GRK6_HUMANLT4R1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa05032Morphine addiction
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function


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