Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATF2_HUMAN
Description:activating transcription factor 2 [Source:HGNC Symbol;Acc:784]
Location:chr2 q31.1
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T69IVADQtPTPTRMAPK14HPRD
T71ADQTPtPTRFLMAPK9HPRD
T53ADQTPtPTRFLMAPK8phosphoELM
S322QTQSTsGRRRRPKC_betaphosphoELM
S307LVRTQsEESRPPhosphoSitePlus
T69IVADQtPTPTRMAPK9HPRD
T98LSPLAtPIIRSphosphoELM
T305SGLVRtQSEESPhosphoSitePlus
S62PARNDsVIVADPhosphoSitePlus
T333SPAHTtPQTQSPhosphoSitePlus
T53ADQTPtPTRFLJNK1(MAPK8RegPhos
S349NRAAAsRCRQKPKC_betaphosphoELM
S472TEPALsQIVMAATMphosphoELM; RegPhos
S44PARNDsVIVADVRK1RegPhos
S322QTQSTsGRRRRPKC_groupphosphoELM; RegPhos
S367NRAAAsRCRQKbZIP_1PhosphoSitePlus
T51IVADQtPTPTRp38aRegPhos
T53ADQTPtPTRFLJNK2RegPhos
S94MPLDLsPLATPphosphoELM; RegPhos; SysPTM
T290QHPPVtNGDTVPhosphoSitePlus
S72FNELAsPFENEp38aRegPhos
S44PARNDsVIVADphosphoELM
S328TETPAsPAHTTPhosphoSitePlus
S490TEPALsQIVMAPhosphoSitePlus
S310TETPAsPAHTTphosphoELM
S498VMAPSsQSQPSPhosphoSitePlus
S121TPIIRsKIEEPPhosphoSitePlus
S322QTQSTsGRRRRPKCb(PKC betaRegPhos
S480VMAPSsQSQPSATMphosphoELM; RegPhos
S340QTQSTsGRRRRPhosphoSitePlus
T283LKAALtQQHPPPhosphoSitePlus
T51IVADQtPTPTRp38a(MAPK14RegPhos
T53ADQTPtPTRFLp38a(MAPK14RegPhos
T55QTPTPtRFLKNphosphoELM
T73QTPTPtRFLKNPhosphoSitePlus; HPRD
T336HTTPQtQSTSGPhosphoSitePlus
S136TTHQDsPLPHPPhosphoSitePlus
S349NRAAAsRCRQKPKC_groupphosphoELM; RegPhos
T69IVADQtPTPTRPhosphoSitePlus
T51IVADQtPTPTRJNK2RegPhos
T51IVADQtPTPTRJNK1(MAPK8RegPhos
T116LSPLAtPIIRSPhosphoSitePlus; HPRD
T53ADQTPtPTRFLphosphoELM
T71ADQTPtPTRFLPhosphoSitePlus
S349NRAAAsRCRQKPKCb(PKC betaRegPhos
S112MPLDLsPLATPPhosphoSitePlus; HPRD
T52HKHEMtLKFGPPhosphoSitePlus
T55QTPTPtRFLKNVRK1phosphoELM; RegPhos
S90FNELAsPFENEMAPK14HPRD
T53ADQTPtPTRFLp38aRegPhos
T71ADQTPtPTRFLMAPK14HPRD
S44PARNDsVIVADPKA_groupphosphoELM; RegPhos
T53ADQTPtPTRFLMAPK14phosphoELM
T51IVADQtPTPTRphosphoELM
S90FNELAsPFENEPhosphoSitePlus

Dephosphorylation site
ATF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376327D352HHPIBreast Cancer16959974
ENSP00000264110D352HHPIBreast Cancer16959974

Differential expressed protein
ATF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ATF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANATF2_HUMANkinase -> substrateRegPhos
MK10_HUMANATF2_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANATF2_HUMANkinase -> substrateRegPhos
VRK1_HUMANATF2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
DYRK2_HUMANATF2_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANATF2_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK08_HUMANATF2_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK11_HUMANATF2_HUMANkinase -> substrateNetPath
MK09_HUMANATF2_HUMANkinase -> substrateRegPhos
ATF2_HUMANTPA_HUMANTF -> target geneTRANSFAC
ATF2_HUMANCCL5_HUMANTF -> target geneTRANSFAC
ATF2_HUMANMLTK_HUMANTF -> target geneTRANSFAC
AP2A_HUMANATF2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANFOS_HUMANTF -> target geneTRANSFAC
ATF2_HUMANGLHA_HUMANTF -> target geneTRANSFAC
ATF2_HUMANFINC_HUMANTF -> target geneTRANSFAC
SP1_HUMANATF2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANIFNB_HUMANTF -> target geneTRANSFAC
ATF2_HUMANRB_HUMANTF -> target geneTRANSFAC
ATF2_HUMANTNFA_HUMANTF -> target geneTRANSFAC
ATF2_HUMANUROK_HUMANTF -> target geneTRANSFAC
ATF2_HUMANTGFB2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANATF3_HUMANTF -> target geneTRANSFAC
ATF2_HUMANLYAM2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANATF2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANVIP_HUMANTF -> target geneTRANSFAC
ATF2_HUMANDPOLB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05030Cocaine addiction
hsa05034Alcoholism
hsa04728Dopaminergic synapse
hsa05166HTLV-I infection
hsa05031Amphetamine addiction
hsa05169Epstein-Barr virus infection
hsa05164Influenza A
hsa04010MAPK signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001076RNA polymerase II transcription factor binding traICmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIICbiological_process
GO:0016020membraneIEAcellular_component
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0035497cAMP response element bindingIDAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0008140cAMP response element binding protein bindingIDAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060612adipose tissue developmentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiICmolecular_function
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0006970response to osmotic stressIDAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0001102RNA polymerase II activating transcription factor IPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0035497cAMP response element bindingIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0006366transcription from RNA polymerase II promoterICbiological_process
GO:0032915positive regulation of transforming growth factor IEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process