Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RIPK2_HUMAN
Description:receptor-interacting serine-threonine kinase 2 [Source:HGNC Symbol;Acc:10020]
Location:chr8 q21.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S178MSLSQsRSSKSPkinasePhosphoSitePlus; SysPTM
Y474IMKEDyELVSTCARDPhosphoSitePlus
Y520MGLQPyPEILVHPRD
S531VSRSPsLNLLQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S345GPQEEsCGSSQPhosphoSitePlus; HPRD
S348EESCGsSQLHEHPRD
S176RMMSLsQSRSSHPRD; phosphoELM; SysPTM
T482VSTKPtRTSKVHPRD
S168ADFGLsKWRMMHPRD; SysPTM
S539LLQNKHPRD; SysPTM
S527EILVVsRSPSLPhosphoSitePlus; HPRD; SysPTM
S357HENSGsPETSRPhosphoSitePlus
S178MSLSQsRSSKSHPRD; SysPTM
S393CPGNHsWDSTIPhosphoSitePlus
S363PETSRsLPAPQPhosphoSitePlus; HPRD; SysPTM
S176RMMSLsQSRSSPkinasePhosphoSitePlus; SysPTM
S539LLQNKsM____PhosphoSitePlus; SysPTM
S529LVVSRsPSLNLPhosphoSitePlus; HPRD; SysPTM
S168ADFGLsKWRMMPkinasePhosphoSitePlus; SysPTM
S174KWRMMsLSQSRPkinasePhosphoSitePlus
S181SQSRSsKSAPEPkinasePhosphoSitePlus
Y474IMKEDyELVSTHPRD
Y381KAQDCyFMKLHPhosphoSitePlus; HPRD

Dephosphorylation site
RIPK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000441623*404SCOSMICCentral Nervous System Neoplasms10560660
ENSP00000220751I208NTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RIPK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y474CARDDLIMKEDyELVSTKPCrohn disease21123652PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
RIPK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANCDKL3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RIPK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0032728positive regulation of interferon-beta productionNASbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayIEAbiological_process
GO:0045087innate immune responseISSbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0070555response to interleukin-1IEAbiological_process
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0070673response to interleukin-18IEAbiological_process
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0071223cellular response to lipoteichoic acidIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0002250adaptive immune responseISSbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0071224cellular response to peptidoglycanIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0070427nucleotide-binding oligomerization domain containiIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0032874positive regulation of stress-activated MAPK cascaIEAbiological_process
GO:0001961positive regulation of cytokine-mediated signalingIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0032743positive regulation of interleukin-2 productionIEAbiological_process
GO:0032727positive regulation of interferon-alpha productionNASbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0030274LIM domain bindingIPImolecular_function
GO:0070431nucleotide-binding oligomerization domain containiIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyNASbiological_process
GO:0032735positive regulation of interleukin-12 productionNASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeISSbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0033091positive regulation of immature T cell proliferatiIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0050700CARD domain bindingIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0045627positive regulation of T-helper 1 cell differentiaIEAbiological_process
GO:0070671response to interleukin-12IEAbiological_process
GO:0002250adaptive immune responseIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0032722positive regulation of chemokine productionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002827positive regulation of T-helper 1 type immune respIEAbiological_process
GO:0031398positive regulation of protein ubiquitinationIMPbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process