Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRAF2_HUMAN
Description:TNF receptor-associated factor 2 [Source:HGNC Symbol;Acc:12032]
Location:chr9 q34.3
Node attribute:PPI(target); ubiquitination(source); ubiquitination(target); substrate; receptor; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S5TPPGHPRD
T431FNQKVtLMLLDMATHPhosphoSitePlus
S5_MAAAsVTPPGPhosphoSitePlus
T7AAASVtPPGSLPhosphoSitePlus
S55GHRYCsFCLASzf-C3HC4PhosphoSitePlus
T117CTWKGtLKEYEPhosphoSitePlus
T7PGSLHPRD
S11VTPPGsLELLQPhosphoSitePlus; HPRD
S20LQPGFsKTLLGHPRD
T401LNGDGtGRGTHMATHPhosphoSitePlus
T22PGFSKtLLGTKPhosphoSitePlus; HPRD
S274LQRCEsLEKKTReo_sigmaC; Cep57_CLDPhosphoSitePlus
Y121GTLKEyESCHEPhosphoSitePlus
T26KTLLGtKLEAKPhosphoSitePlus

Dephosphorylation site
TRAF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000446414L268FCOSMICOvarian Cancer21720365
ENSP00000247668R385TBIOMARTBreast Cancer21930507, 21930502
ENSP00000446414E200DCOSMICHead and Neck Cancer21798893
ENSP00000446414Q457LCOSMICBreast Cancer
ENSP00000247668Q457LCOSMICBreast Cancer
ENSP00000247668L268FCOSMICOvarian Cancer21720365
ENSP00000247668L268FTCGAOvarian Cancer21720365, 18772890
ENSP00000247668E200DCOSMICHead and Neck Cancer21798893
ENSP00000446414L268FTCGAOvarian Cancer21720365, 18772890
ENSP00000352685R437TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000247668Uterine CancerNormal vs. Cancercell lineDown0.2215838902

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S55zf-C3HC4QCGHRYCsFCLASILHodgkin's lymphoma19336568PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GSTP1_HUMANTRAF2_HUMANligand -> receptorHPMR
KPCE_HUMANTRAF2_HUMANkinase -> substrateNetPath
KPCD_HUMANTRAF2_HUMANkinase -> substrateNetPath
KPCZ_HUMANTRAF2_HUMANkinase -> substrateNetPath
BIRC2_HUMANTRAF2_HUMANubiquitinationNetPath
CSN5_HUMANTRAF2_HUMANubiquitinationNetPath
TRAF2_HUMANRIPK1_HUMANubiquitinationNetPath
TNR1B_HUMANTRAF2_HUMANotherKEGG
TRAF2_HUMANMK08_HUMANotherKEGG
TRAF2_HUMANM4K2_HUMANotherKEGG
TNR1A_HUMANTRAF2_HUMANotherKEGG
TRADD_HUMANTRAF2_HUMANotherKEGG
TRAF2_HUMANIKKA_HUMANotherKEGG
TRAF2_HUMANMTOR_HUMANotherKEGG
TRAF2_HUMANM3K1_HUMANotherKEGG
TRAF2_HUMANM3K5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04622RIG-I-like receptor signaling pathway
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa04380Osteoclast differentiation
hsa04210Apoptosis
hsa05222Small cell lung cancer
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05203Viral carcinogenesis
hsa04920Adipocytokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0051865protein autoubiquitinationTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035631CD40 receptor complexIEAcellular_component
GO:0033209tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0030163protein catabolic processIEAbiological_process
GO:0002726positive regulation of T cell cytokine productionIMPbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0046625sphingolipid bindingIDAmolecular_function
GO:0007250activation of NF-kappaB-inducing kinase activityIMPbiological_process
GO:0051023regulation of immunoglobulin secretionIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0032743positive regulation of interleukin-2 productionIMPbiological_process
GO:0043623cellular protein complex assemblyIEAbiological_process
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005164tumor necrosis factor receptor bindingIPImolecular_function
GO:0043507positive regulation of JUN kinase activityIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0004871signal transducer activityNASmolecular_function
GO:0090073positive regulation of protein homodimerization acIMPbiological_process
GO:0050870positive regulation of T cell activationICbiological_process
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0070207protein homotrimerizationIPIbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005174CD40 receptor bindingIEAmolecular_function
GO:0031996thioesterase bindingIPImolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function


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