| UniProt/SwissProt ID: | JIP3_HUMAN |
| Description: | mitogen-activated protein kinase 8 interacting protein 3 [Source:HGNC Symbol;Acc:6884] |
| Location: | chr16 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S314 | REKRDsRNMEV | PhosphoSitePlus | |
| T779 | WILTStLTTSK | PhosphoSitePlus | |
| T206 | RKERPtSLNVF | PhosphoSitePlus | |
| T265 | SSAAAtPSTTG | MAPK_group | RegPhos |
| T605 | YKSPTtAGFSQ | PhosphoSitePlus | |
| S602 | NIHYKsPTTAG | PhosphoSitePlus | |
| T275 | GTKSNtPTSSV | MAPK_group | RegPhos |
| S365 | DRTGSsPTQGI | PhosphoSitePlus; RegPhos | |
| T265 | SSAAAtPSTTG | MAPK8 | HPRD |
| S585 | FSSSSsPPPAK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T286 | PSAAVtPLNES | MAPK8 | HPRD |
| T275 | GTKSNtPTSSV | MAPK10 | HPRD |
| T913 | EPETAtLRPGP | PhosphoSitePlus; HPRD | |
| T684 | GGQEDtRMKNV | PhosphoSitePlus; HPRD | |
| S364 | LDRTGsSPTQG | PhosphoSitePlus | |
| T275 | GTKSNtPTSSV | JNK3 | RegPhos |
| T275 | GTKSNtPTSSV | JNK1 | RegPhos |
| T265 | SSAAAtPSTTG | JNK3 | RegPhos |
| T265 | SSAAAtPSTTG | JNK1 | RegPhos |
| T286 | PSAAVtPLNES | MAPK_group | RegPhos |
| S676 | KYKQLsPNGGQ | PhosphoSitePlus; HPRD; RegPhos | |
| S1286 | NVLVLsGGEGY | PhosphoSitePlus | |
| T275 | GTKSNtPTSSV | MAPK8 | HPRD |
| S1143 | GKLGFsFVRIT | PhosphoSitePlus; HPRD; phosphoELM | |
| S267 | AAATPsTTGTK | RegPhos | |
| T286 | PSAAVtPLNES | MAPK10 | HPRD |
| T265 | SSAAAtPSTTG | MAPK10 | HPRD |
| S716 | AGVNLsGWRPN | PhosphoSitePlus; HPRD | |
| T286 | PSAAVtPLNES | JNK1 | RegPhos |
| T286 | PSAAVtPLNES | JNK3 | RegPhos |
| Dephosphorylation site |
| JIP3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000250894 | R550Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| JIP3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| JIP3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK10_HUMAN | JIP3_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | JIP3_HUMAN | kinase -> substrate | RegPhos |
| MK08_HUMAN | JIP3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007257 | activation of JUN kinase activity | IEA | biological_process |
| GO:0019894 | kinesin binding | IEA | molecular_function |
| GO:0009791 | post-embryonic development | IEA | biological_process |
| GO:0048286 | lung alveolus development | IEA | biological_process |
| GO:0005790 | smooth endoplasmic reticulum | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030673 | axolemma | IEA | cellular_component |
| GO:0016192 | vesicle-mediated transport | ISS | biological_process |
| GO:0043507 | positive regulation of JUN kinase activity | IEA | biological_process |
| GO:0007585 | respiratory gaseous exchange | IEA | biological_process |
| GO:0046328 | regulation of JNK cascade | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046328 | regulation of JNK cascade | ISS | biological_process |
| GO:0019894 | kinesin binding | ISS | molecular_function |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0010468 | regulation of gene expression | IEA | biological_process |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0005078 | MAP-kinase scaffold activity | IEA | molecular_function |
| GO:0031434 | mitogen-activated protein kinase kinase binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0031435 | mitogen-activated protein kinase kinase kinase bin | IEA | molecular_function |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0008432 | JUN kinase binding | IEA | molecular_function |
| GO:0019901 | protein kinase binding | ISS | molecular_function |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0008104 | protein localization | IEA | biological_process |
| GO:0060425 | lung morphogenesis | IEA | biological_process |
| GO:0000139 | Golgi membrane | ISS | cellular_component |
| GO:0005078 | MAP-kinase scaffold activity | ISS | molecular_function |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0007254 | JNK cascade | IEA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |