Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JIP3_HUMAN
Description:mitogen-activated protein kinase 8 interacting protein 3 [Source:HGNC Symbol;Acc:6884]
Location:chr16 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S314REKRDsRNMEVPhosphoSitePlus
T779WILTStLTTSKPhosphoSitePlus
T206RKERPtSLNVFPhosphoSitePlus
T265SSAAAtPSTTGMAPK_groupRegPhos
T605YKSPTtAGFSQPhosphoSitePlus
S602NIHYKsPTTAGPhosphoSitePlus
T275GTKSNtPTSSVMAPK_groupRegPhos
S365DRTGSsPTQGIPhosphoSitePlus; RegPhos
T265SSAAAtPSTTGMAPK8HPRD
S585FSSSSsPPPAKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T286PSAAVtPLNESMAPK8HPRD
T275GTKSNtPTSSVMAPK10HPRD
T913EPETAtLRPGPPhosphoSitePlus; HPRD
T684GGQEDtRMKNVPhosphoSitePlus; HPRD
S364LDRTGsSPTQGPhosphoSitePlus
T275GTKSNtPTSSVJNK3RegPhos
T275GTKSNtPTSSVJNK1RegPhos
T265SSAAAtPSTTGJNK3RegPhos
T265SSAAAtPSTTGJNK1RegPhos
T286PSAAVtPLNESMAPK_groupRegPhos
S676KYKQLsPNGGQPhosphoSitePlus; HPRD; RegPhos
S1286NVLVLsGGEGYPhosphoSitePlus
T275GTKSNtPTSSVMAPK8HPRD
S1143GKLGFsFVRITPhosphoSitePlus; HPRD; phosphoELM
S267AAATPsTTGTKRegPhos
T286PSAAVtPLNESMAPK10HPRD
T265SSAAAtPSTTGMAPK10HPRD
S716AGVNLsGWRPNPhosphoSitePlus; HPRD
T286PSAAVtPLNESJNK1RegPhos
T286PSAAVtPLNESJNK3RegPhos

Dephosphorylation site
JIP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000250894R550QBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
JIP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
JIP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANJIP3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANJIP3_HUMANkinase -> substrateRegPhos
MK08_HUMANJIP3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0019894kinesin bindingIEAmolecular_function
GO:0009791post-embryonic developmentIEAbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0005790smooth endoplasmic reticulumIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0030673axolemmaIEAcellular_component
GO:0016192vesicle-mediated transportISSbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0007585respiratory gaseous exchangeIEAbiological_process
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046328regulation of JNK cascadeISSbiological_process
GO:0019894kinesin bindingISSmolecular_function
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0005078MAP-kinase scaffold activityIEAmolecular_function
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0008432JUN kinase bindingIEAmolecular_function
GO:0019901protein kinase bindingISSmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0008104protein localizationIEAbiological_process
GO:0060425lung morphogenesisIEAbiological_process
GO:0000139Golgi membraneISScellular_component
GO:0005078MAP-kinase scaffold activityISSmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function


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