Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ELK1_HUMAN
Description:ELK1, member of ETS oncogene family [Source:HGNC Symbol;Acc:3321]
Location:chrX p11.23
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S198PSGSRsTSPSPHPRD
S383FWSTLsPIAPRTAO2RegPhos
S160RSGLYsTFTIQPhosphoSitePlus
S389PIAPRsPAKLSJNK2RegPhos
Y57KTNMNyDKLSREtsPhosphoSitePlus
T417VDGLStPVVLSPRP4phosphoELM; RegPhos
S383FWSTLsPIAPRMAPK9HPRD
S383FWSTLsPIAPRMAPK1HPRD
S383FWSTLsPIAPRMAPK3phosphoELM
S383FWSTLsPIAPRErk2(MAPK1RegPhos
T368TPVLLtPSSLPPhosphoSitePlus
S166TFTIQsLQPQPPhosphoSitePlus
S389PIAPRsPAKLSJNK2(MAPK9RegPhos
S383FWSTLsPIAPRPhosphoSitePlus; phosphoELM
S383FWSTLsPIAPRMAPK14HPRD; phosphoELM
S416SVDGLsTPVVLPhosphoSitePlus
S383FWSTLsPIAPRErk1(MAPK3RegPhos
S389PIAPRsPAKLSp38a(MAPK14RegPhos
S324LELPLsPSLLGErk2(MAPK1RegPhos
S383FWSTLsPIAPRp38a(MAPK14RegPhos
T363PTHTLtPVLLTPhosphoSitePlus
S324LELPLsPSLLGPhosphoSitePlus; HPRD; phosphoELM
S389PIAPRsPAKLSErk2(MAPK1RegPhos
S422TPVVLsPGPQKPhosphoSitePlus
S422TPVVLsPGPQKErk2(MAPK1RegPhos
S304GHAASsPEISQPhosphoSitePlus; HPRD; phosphoELM
S389PIAPRsPAKLSp38aRegPhos
S383FWSTLsPIAPRJNK2(MAPK9RegPhos
S389PIAPRsPAKLSPhosphoSitePlus; phosphoELM
S383FWSTLsPIAPRErk2RegPhos
S389PIAPRsPAKLSErk1(MAPK3RegPhos
S383FWSTLsPIAPRp38aRegPhos
T417VDGLStPVVLSPhosphoSitePlus
T353PGPALtPSLLPPhosphoSitePlus
S389PIAPRsPAKLSMAPK3phosphoELM
S389PIAPRsPAKLSMAPK9HPRD
S383FWSTLsPIAPRJNK2RegPhos
T336PGPERtPGSGSErk2(MAPK1RegPhos
S389PIAPRsPAKLSMAPK14HPRD; phosphoELM
S383FWSTLsPIAPRTAOK2HPRD
S326LPLSPsLLGGPPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
ELK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366182P131QCOSMICSkin Cancer21984974
ENSP00000366182C99FCOSMICOvarian Cancer21720365
ENSP00000366182K35NCOSMICOvarian Cancer21720365
ENSP00000247161K35NCOSMICOvarian Cancer21720365
ENSP00000247161C99FCOSMICOvarian Cancer21720365
ENSP00000247161P131QCOSMICSkin Cancer21984974

Differential expressed protein
ELK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T417ISVDGLStPVVLSPGcolorectal carcinoma23114923PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANELK1_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
MK03_HUMANELK1_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK14_HUMANELK1_HUMANkinase -> substrateKEGG; HPRD; NetPath; Robert H Newman (2013)
MK09_HUMANELK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PRP4_HUMANELK1_HUMANkinase -> substrateRegPhos
MK01_HUMANELK1_HUMANkinase -> substrateNetPath
TAOK2_HUMANELK1_HUMANkinase -> substrateHPRD
ELK1_HUMANCCND1_HUMANTF -> target geneKEGG
ELK1_HUMANBIRC2_HUMANTF -> target geneKEGG
ELK1_HUMANELK1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANELK1_HUMANTF -> target geneTRANSFAC
ELK1_HUMANNOS3_HUMANTF -> target geneTRANSFAC
ELK1_HUMANSRF_HUMANTF -> target geneTRANSFAC
ELK1_HUMANFOS_HUMANTF -> target geneTRANSFAC
SRF_HUMANELK1_HUMANTF -> target geneTRANSFAC
ELK1_HUMANEGR2_HUMANTF -> target geneTRANSFAC
ELK1_HUMANACTB_HUMANTF -> target geneTRANSFAC
ELK1_HUMANTNFA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04910Insulin signaling pathway
hsa05020Prion diseases
hsa05213Endometrial cancer
hsa04010MAPK signaling pathway
hsa05166HTLV-I infection
hsa05140Leishmaniasis
hsa04912GnRH signaling pathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005634nucleusICcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process


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