| UniProt/SwissProt ID: | ELK1_HUMAN |
| Description: | ELK1, member of ETS oncogene family [Source:HGNC Symbol;Acc:3321] |
| Location: | chrX p11.23 |
| Node attribute: | gene; substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S198 | PSGSRsTSPSP | HPRD | |
| S383 | FWSTLsPIAPR | TAO2 | RegPhos |
| S160 | RSGLYsTFTIQ | PhosphoSitePlus | |
| S389 | PIAPRsPAKLS | JNK2 | RegPhos |
| Y57 | KTNMNyDKLSR | Ets | PhosphoSitePlus |
| T417 | VDGLStPVVLS | PRP4 | phosphoELM; RegPhos |
| S383 | FWSTLsPIAPR | MAPK9 | HPRD |
| S383 | FWSTLsPIAPR | MAPK1 | HPRD |
| S383 | FWSTLsPIAPR | MAPK3 | phosphoELM |
| S383 | FWSTLsPIAPR | Erk2(MAPK1 | RegPhos |
| T368 | TPVLLtPSSLP | PhosphoSitePlus | |
| S166 | TFTIQsLQPQP | PhosphoSitePlus | |
| S389 | PIAPRsPAKLS | JNK2(MAPK9 | RegPhos |
| S383 | FWSTLsPIAPR | PhosphoSitePlus; phosphoELM | |
| S383 | FWSTLsPIAPR | MAPK14 | HPRD; phosphoELM |
| S416 | SVDGLsTPVVL | PhosphoSitePlus | |
| S383 | FWSTLsPIAPR | Erk1(MAPK3 | RegPhos |
| S389 | PIAPRsPAKLS | p38a(MAPK14 | RegPhos |
| S324 | LELPLsPSLLG | Erk2(MAPK1 | RegPhos |
| S383 | FWSTLsPIAPR | p38a(MAPK14 | RegPhos |
| T363 | PTHTLtPVLLT | PhosphoSitePlus | |
| S324 | LELPLsPSLLG | PhosphoSitePlus; HPRD; phosphoELM | |
| S389 | PIAPRsPAKLS | Erk2(MAPK1 | RegPhos |
| S422 | TPVVLsPGPQK | PhosphoSitePlus | |
| S422 | TPVVLsPGPQK | Erk2(MAPK1 | RegPhos |
| S304 | GHAASsPEISQ | PhosphoSitePlus; HPRD; phosphoELM | |
| S389 | PIAPRsPAKLS | p38a | RegPhos |
| S383 | FWSTLsPIAPR | JNK2(MAPK9 | RegPhos |
| S389 | PIAPRsPAKLS | PhosphoSitePlus; phosphoELM | |
| S383 | FWSTLsPIAPR | Erk2 | RegPhos |
| S389 | PIAPRsPAKLS | Erk1(MAPK3 | RegPhos |
| S383 | FWSTLsPIAPR | p38a | RegPhos |
| T417 | VDGLStPVVLS | PhosphoSitePlus | |
| T353 | PGPALtPSLLP | PhosphoSitePlus | |
| S389 | PIAPRsPAKLS | MAPK3 | phosphoELM |
| S389 | PIAPRsPAKLS | MAPK9 | HPRD |
| S383 | FWSTLsPIAPR | JNK2 | RegPhos |
| T336 | PGPERtPGSGS | Erk2(MAPK1 | RegPhos |
| S389 | PIAPRsPAKLS | MAPK14 | HPRD; phosphoELM |
| S383 | FWSTLsPIAPR | TAOK2 | HPRD |
| S326 | LPLSPsLLGGP | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| ELK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000366182 | P131Q | COSMIC | Skin Cancer | 21984974 | ENSP00000366182 | C99F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000366182 | K35N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000247161 | K35N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000247161 | C99F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000247161 | P131Q | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| ELK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| T417 | ISVDGLStPVVLSPG | colorectal carcinoma | 23114923 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | ELK1_HUMAN | kinase -> substrate | KEGG; Robert H Newman (2013) |
| MK03_HUMAN | ELK1_HUMAN | kinase -> substrate | NetPath; Robert H Newman (2013) |
| MK14_HUMAN | ELK1_HUMAN | kinase -> substrate | KEGG; HPRD; NetPath; Robert H Newman (2013) |
| MK09_HUMAN | ELK1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| PRP4_HUMAN | ELK1_HUMAN | kinase -> substrate | RegPhos |
| MK01_HUMAN | ELK1_HUMAN | kinase -> substrate | NetPath |
| TAOK2_HUMAN | ELK1_HUMAN | kinase -> substrate | HPRD |
| ELK1_HUMAN | CCND1_HUMAN | TF -> target gene | KEGG |
| ELK1_HUMAN | BIRC2_HUMAN | TF -> target gene | KEGG |
| ELK1_HUMAN | ELK1_HUMAN | TF -> target gene | TRANSFAC |
| EGR1_HUMAN | ELK1_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | NOS3_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | SRF_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | FOS_HUMAN | TF -> target gene | TRANSFAC |
| SRF_HUMAN | ELK1_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | EGR2_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | ACTB_HUMAN | TF -> target gene | TRANSFAC |
| ELK1_HUMAN | TNFA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04510 | Focal adhesion |
| hsa04910 | Insulin signaling pathway |
| hsa05020 | Prion diseases |
| hsa05213 | Endometrial cancer |
| hsa04010 | MAPK signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa05140 | Leishmaniasis |
| hsa04912 | GnRH signaling pathway |
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005634 | nucleus | IC | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |