Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK07_HUMAN
Description:mitogen-activated protein kinase 7 [Source:HGNC Symbol;Acc:6880]
Location:chr17 p11.2
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y221YFMTEyVATRWHPRD
S754EFLNQsFDMGVPhosphoSitePlus
S720QQLSKsQVEDPPhosphoSitePlus; HPRD
S421DVEMPsPWAPSPhosphoSitePlus
S562AGLVLsDNDRSU79_P34PhosphoSitePlus
S71YGVVSsARRRLPkinasePhosphoSitePlus
Y82YFMTEyVATRWHPRD
S282VLGTPsPAVIQPkinasePhosphoSitePlus
S718VTQQLsKSQVEPhosphoSitePlus
S592LPPVFsGTPKGHPRD
T80HQYFMtEYVATHPRD
S567SDNDRsLLERWU79_P34PhosphoSitePlus
S707SSMSEsPDVNLPhosphoSitePlus
S472KDGAIsDNTKAPhosphoSitePlus
T280MMVLGtPSPAVPkinasePhosphoSitePlus
T219HQYFMtEYVATPkinasePhosphoSitePlus
T584AAPALtSVPAPPhosphoSitePlus; HPRD
S322DRQALsLLGRMPkinasePhosphoSitePlus
S776ASLSAsLLADWPhosphoSitePlus
S770DGQADsASLSAPhosphoSitePlus
T445AAPALtSVPAPHPRD
S581QQLSKsQVEDPHPRD
S70AYGVVsSARRRPkinasePhosphoSitePlus
S486AALLKsLRSRLPhosphoSitePlus
S31AHTAAsVAAKNPhosphoSitePlus
Y221YFMTEyVATRWPkinasePhosphoSitePlus
S433DCAMEsPPPAPPhosphoSitePlus
S496LRDGPsAPLEAPhosphoSitePlus
S731LPPVFsGTPKGPhosphoSitePlus; HPRD
T218HQYFMtEYVATphosphoELM
Y220YFMTEyVATRWphosphoELM
T733PVFSGtPKGSGPhosphoSitePlus; HPRD
T28AEPAHtAASVAPhosphoSitePlus
T594PVFSGtPKGSGHPRD
S774DSASLsASLLAPhosphoSitePlus
Y216PAEHQyFMTEYPkinasePhosphoSitePlus
S772QADSAsLSASLPhosphoSitePlus
T219HQYFMtEYVATHPRD
T224TEYVAtRWYRAPkinasePhosphoSitePlus
S803EIQMDsPMLLAPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y221HQYFMTEyVATRWYRPTPRRHPRD
Y82HQYFMTEyVATRWYRPTPRRHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378968A590TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000378968G697RBIOMARTLung Cancer21930507, 21930502
ENSP00000378966A590TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000378966G697RDing2008Lung Cancer18948947
ENSP00000378968G697RDing2008Lung Cancer18948947
ENSP00000311005A590TTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
MK07_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK07_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK07_HUMANETS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
JAK2_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
STK38_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMEF2C_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK07_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
RAGE_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMP2K5_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANSGK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PKN1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KCC2B_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANTF3C3_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANNR4A1_HUMANkinase -> substrateKEGG
MK07_HUMANCXA1_HUMANkinase -> substrateHPRD
MK07_HUMANRXRA_HUMANkinase -> substrateHPRD
MK07_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMEF2D_HUMANkinase -> substrateHPRD
MK07_HUMANMEF2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MP2K5_HUMANMK07_HUMANkinase -> substrateKEGG
PTPRR_HUMANMK07_HUMANphosphatase -> substrateHPRD
KPCA_HUMANMK07_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04540Gap junction
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0071363cellular response to growth factor stimulusIGIbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0070301cellular response to hydrogen peroxideIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIGIbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0051534negative regulation of NFAT protein import into nuIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0071499cellular response to laminar fluid shear stressTASbiological_process
GO:0043066negative regulation of apoptotic processIGIbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034115negative regulation of heterotypic cell-cell adhesIGIbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0051019mitogen-activated protein kinase bindingIPImolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0060761negative regulation of response to cytokine stimulIGIbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0060548negative regulation of cell deathIMPbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0051247positive regulation of protein metabolic processIGIbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0050728negative regulation of inflammatory responseTASbiological_process
GO:0036003positive regulation of transcription from RNA polyIMPbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process