Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARAP1_HUMAN
Description:ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol;Acc:16925]
Location:chr11 q13.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T354WVRLDtDHLRYHPRD
Y231FDDSDyDEVPEHPRD
T109WVRLDtDHLRYHPRD
Y431RLSSAyLLGVPHPRD
Y186RLSSAyLLGVPHPRD
S229PEFDDsDYDEVHPRD
Y492PLEKHySVVLPHPRD
S1190NEMRRsVAAFTHPRD
S428ARARLsSAYLLHPRD
S1435NEMRRsVAAFTHPRD
Y737PLEKHySVVLPHPRD
Y730IPVIVyRCVDYHPRD
T173LVSLPtKEEESHPRD
Y975IPVIVyRCVDYHPRD
S183ARARLsSAYLLHPRD
Y735IPVIVyRCVDYphosphoELM

Dephosphorylation site
ARAP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377230E527KCOSMICSkin Cancer21984974
ENSP00000377230S188FCOSMICMelanoma21499247
ENSP00000377230A884fs*34COSMICOvarian Cancer21720365

Differential expressed protein
ARAP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARAP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK4_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ARAP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051270regulation of cellular component movementIMPbiological_process
GO:0030037actin filament reorganization involved in cell cycTASbiological_process
GO:0005100Rho GTPase activator activityIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005096GTPase activator activityIEAmolecular_function
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0032312regulation of ARF GTPase activityIEAbiological_process
GO:0051497negative regulation of stress fiber assemblyIMPbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0051491positive regulation of filopodium assemblyIMPbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008060ARF GTPase activator activityIDAmolecular_function
GO:0043089positive regulation of Cdc42 GTPase activityIDAbiological_process


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