Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TIF1B_HUMAN
Description:tripartite motif containing 28 [Source:HGNC Symbol;Acc:16384]
Location:chr19 q13.43
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S471SGVKRsRSGEGPhosphoSitePlus; HPRD; phosphoELM
T541TAPAGtPGAPPPhosphoSitePlus; HPRD; phosphoELM
Y369SKKLIyFQLHRPhosphoSitePlus
S258RKLLAsLVKRLHPRD; phosphoELM
Y242HKDHQyQFLEDzf-B_box; DUF1664PhosphoSitePlus
S4AAASHPRD
S479GEGEVsGLMRKPhosphoSitePlus; HPRD
S17AASAAsGSPGPPhosphoSitePlus; HPRD
S50SAAASsPAGGGPhosphoSitePlus; HPRD; phosphoELM
S697VVAKLsPANQRPhosphoSitePlus; HPRD
S596RLASPsGSTSSPhosphoSitePlus; HPRD; phosphoELM
S612APEGTsAPGGGPhosphoSitePlus; HPRD
T620GGGPGtLDDSAHPRD
S756LSPPYsSPQEFPhosphoSitePlus; HPRD; phosphoELM
Y517STTEDyNLIVIPhosphoSitePlus
S19SAASGsPGPGEPhosphoSitePlus; HPRD; phosphoELM
S601SGSTSsGLEVVPhosphoSitePlus; HPRD; phosphoELM
S460DDPYSsAEPHVPhosphoSitePlus
S26GPGEGsAGGEKPhosphoSitePlus; HPRD
S594GPRLAsPSGSTPhosphoSitePlus; HPRD; phosphoELM
S757SPPYSsPQEFAPhosphoSitePlus; HPRD; phosphoELM
S683EDGSLsLDGADPhosphoSitePlus; HPRD
S784KADVQsIIGLQPhosphoSitePlus
S823PGAGLsSQELSPhosphoSitePlus; HPRD; phosphoELM
S466AEPHVsGVKRSPhosphoSitePlus; HPRD; phosphoELM
S258RKLLAsLVKRLDUF1664PhosphoSitePlus
S4__MAAsAAAASPhosphoSitePlus
S681KEEDGsLSLDGPhosphoSitePlus; HPRD
T514FPGSTtEDYNLPhosphoSitePlus
T599SPSGStSSGLEPhosphoSitePlus; HPRD; phosphoELM
Y133DIVENyFMRDSPhosphoSitePlus
S45ASASAsAAASSPhosphoSitePlus; phosphoELM
T611VAPEGtSAPGGPhosphoSitePlus; HPRD; phosphoELM
S9SAAAAsAAAASPhosphoSitePlus; HPRD
S600PSGSTsSGLEVPhosphoSitePlus; HPRD; phosphoELM
S689LDGADsTGVVAHPRD
S14SAAAAsAASGSPhosphoSitePlus; HPRD
S437LSKQGsGSSQPPhosphoSitePlus; HPRD; phosphoELM
S624GTLDDsATICRPhosphoSitePlus; HPRD; phosphoELM
Y458SGDDPySSAEPPhosphoSitePlus
Y449EVQEGyGFGSGPhosphoSitePlus
Y755KLSPPySSPQEHPRD; phosphoELM
S138YFMRDsGSKAAHPRD
S459GDDPYsSAEPHPhosphoSitePlus
S752LQEKLsPPYSSPhosphoSitePlus; HPRD; phosphoELM
T626LDDSAtICRVCHPRD; phosphoELM
S501DLTADsQPPVFPhosphoSitePlus; HPRD; phosphoELM
S49ASAAAsSPAGGPhosphoSitePlus; HPRD; phosphoELM
S598ASPSGsTSSGLPhosphoSitePlus; HPRD; phosphoELM
S816EPPPMsLPGAGPhosphoSitePlus
S439KQGSGsSQPMEPhosphoSitePlus; HPRD; phosphoELM
S453GYGFGsGDDPYPhosphoSitePlus
T536TGQPGtAPAGTPhosphoSitePlus
S473VKRSRsGEGEVPhosphoSitePlus; HPRD; phosphoELM
T498LDLDLtADSQPPhosphoSitePlus; HPRD
S440QGSGSsQPMEVPhosphoSitePlus; HPRD; phosphoELM
S828SSQELsGGPGDPhosphoSitePlus; HPRD; phosphoELM
S824GAGLSsQELSGPhosphoSitePlus; HPRD; phosphoELM
S489KVPRVsLERLDPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
TIF1B_HUMAN do not have dephosphorylation site.

Mutation site
TIF1B_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000253024Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.1419422301
ENSP00000253024Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496

Hyperphosphorylation site
TIF1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MKNK2_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TIF1B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005719nuclear euchromatinIEAcellular_component
GO:0005720nuclear heterochromatinIEAcellular_component
GO:0043565sequence-specific DNA bindingISSmolecular_function
GO:0008270zinc ion bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0070087chromo shadow domain bindingIPImolecular_function
GO:0016567protein ubiquitinationIDAbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0045739positive regulation of DNA repairIDAbiological_process
GO:0051259protein oligomerizationIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005654nucleoplasmIEAcellular_component
GO:0060028convergent extension involved in axis elongationIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060669embryonic placenta morphogenesisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0000785chromatinIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0016925protein sumoylationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0006281DNA repairIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0001837epithelial to mesenchymal transitionISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process