Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MITF_HUMAN
Description:microphthalmia-associated transcription factor [Source:HGNC Symbol;Acc:7105]
Location:chr3 p14.1
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S50ANQVLsLPCPNHPRD
S401VSPGAsKTSSRHPRD
S378MDDTLsPVGVTHPRD
S482LLSSVsPGASKHPRD
S292RAHGLsLIPSTGSK3BHPRD
S150PPVPGsSAPNSHPRD
S508VSPGAsKTSSRPhosphoSitePlus
S132ANQVLsLPCPNHPRD
S392STGLCsPDLVNHPRD
S175PPVPGsSAPNSHPRD
S477VSPGAsKTSSRHPRD
S511GASKTsSRRSSPhosphoSitePlus
S491MDDTLsPVGVTPhosphoSitePlus
S399RAHGLsLIPSTGSK3BHPRD
S497LLSSVsPGASKHPRD
S307STGLCsPDLVNHPRD
S469MDDTLsPVGVTHPRD
S164SSAPNsPMAMLHPRD
S502VSPGAsKTSSRHPRD
S391LLSSVsPGASKHPRD
S498LLSSVsPGASKHPRD
S383RAHGLsLIPSTGSK3BHPRD
T510PGASKtSSRRSPhosphoSitePlus
S298RAHGLsLIPSTGSK3BHPRD
S485MDDTLsPVGVTHPRD
S398RAHGLsLIPSTGSK3BHPRD
T54SSSSMtSRILLPhosphoSitePlus; RegPhos
S473LLSSVsPGASKHPRD
S180SSAPNsPMAMLPhosphoSitePlus; HPRD
S407STGLCsPDLVNHPRD
S460MDDTLsPVGVTHPRD
S68PPVPGsSAPNSHPRD
S484MDDTLsPVGVTHPRD
S395VSPGAsKTSSRHPRD
S501VSPGAsKTSSRHPRD
S157ANQVLsLPCPNPhosphoSitePlus; HPRD
S301STGLCsPDLVNHPRD
S397LLSSVsPGASKHPRD
S405RAHGLsLIPSTGSK_groupRegPhos
S174PPVPGsSAPNSHPRD
S156ANQVLsLPCPNHPRD
S32TLCLFsRSSSAHPRD
S504LLSSVsPGASKPhosphoSitePlus
S159PPVPGsSAPNSHPRD
S414STGLCsPDLVNPhosphoSitePlus; phosphoELM; SysPTM
S408STGLCsPDLVNHPRD
S486VSPGAsKTSSRHPRD
S384MDDTLsPVGVTHPRD
S502DPLLSsVSPGAPhosphoSitePlus
S141ANQVLsLPCPNHPRD
S374RAHGLsLIPSTGSK3BHPRD
S383STGLCsPDLVNHPRD
S179SSAPNsPMAMLHPRD
S405RAHGLsLIPSTGSK3BRegPhos
S155SSAPNsPMAMLHPRD
S73SSAPNsPMAMLHPRD

Dephosphorylation site
MITF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377880R270LTCGAOvarian Cancer21720365, 18772890
ENSP00000377880N323TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
MITF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MITF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANMITF_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANMITF_HUMANkinase -> substrateRegPhos
KS6A1_HUMANMITF_HUMANkinase -> substrateNetPath
MK01_HUMANMITF_HUMANkinase -> substrateNetPath
FAK1_HUMANMITF_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMITF_HUMANkinase -> substrateRobert H Newman (2013)
MITF_HUMANBCL2_HUMANTF -> target geneTRANSFAC
MITF_HUMANSUIS_HUMANTF -> target geneTRANSFAC
SOX10_HUMANMITF_HUMANTF -> target geneTRANSFAC
MITF_HUMANTYRP2_HUMANTF -> target geneTRANSFAC
MITF_HUMANU627C_HUMANTF -> target geneTRANSFAC
LEF1_HUMANMITF_HUMANTF -> target geneTRANSFAC
CREB1_HUMANMITF_HUMANTF -> target geneTRANSFAC
MITF_HUMANTYRO_HUMANTF -> target geneTRANSFAC
MITF_HUMANTYRP1_HUMANTF -> target geneTRANSFAC
PAX3_HUMANMITF_HUMANTF -> target geneTRANSFAC
MITF_HUMANMAR1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04380Osteoclast differentiation
hsa04916Melanogenesis
hsa05218Melanoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005634nucleusNAScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0030316osteoclast differentiationIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006461protein complex assemblyIDAbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0045670regulation of osteoclast differentiationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0030318melanocyte differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0046849bone remodelingIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0043010camera-type eye developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0030318melanocyte differentiationNASbiological_process
GO:0043234protein complexIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


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