| UniProt/SwissProt ID: | MITF_HUMAN |
| Description: | microphthalmia-associated transcription factor [Source:HGNC Symbol;Acc:7105] |
| Location: | chr3 p14.1 |
| Node attribute: | gene; substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S50 | ANQVLsLPCPN | HPRD | |
| S401 | VSPGAsKTSSR | HPRD | |
| S378 | MDDTLsPVGVT | HPRD | |
| S482 | LLSSVsPGASK | HPRD | |
| S292 | RAHGLsLIPST | GSK3B | HPRD |
| S150 | PPVPGsSAPNS | HPRD | |
| S508 | VSPGAsKTSSR | PhosphoSitePlus | |
| S132 | ANQVLsLPCPN | HPRD | |
| S392 | STGLCsPDLVN | HPRD | |
| S175 | PPVPGsSAPNS | HPRD | |
| S477 | VSPGAsKTSSR | HPRD | |
| S511 | GASKTsSRRSS | PhosphoSitePlus | |
| S491 | MDDTLsPVGVT | PhosphoSitePlus | |
| S399 | RAHGLsLIPST | GSK3B | HPRD |
| S497 | LLSSVsPGASK | HPRD | |
| S307 | STGLCsPDLVN | HPRD | |
| S469 | MDDTLsPVGVT | HPRD | |
| S164 | SSAPNsPMAML | HPRD | |
| S502 | VSPGAsKTSSR | HPRD | |
| S391 | LLSSVsPGASK | HPRD | |
| S498 | LLSSVsPGASK | HPRD | |
| S383 | RAHGLsLIPST | GSK3B | HPRD |
| T510 | PGASKtSSRRS | PhosphoSitePlus | |
| S298 | RAHGLsLIPST | GSK3B | HPRD |
| S485 | MDDTLsPVGVT | HPRD | |
| S398 | RAHGLsLIPST | GSK3B | HPRD |
| T54 | SSSSMtSRILL | PhosphoSitePlus; RegPhos | |
| S473 | LLSSVsPGASK | HPRD | |
| S180 | SSAPNsPMAML | PhosphoSitePlus; HPRD | |
| S407 | STGLCsPDLVN | HPRD | |
| S460 | MDDTLsPVGVT | HPRD | |
| S68 | PPVPGsSAPNS | HPRD | |
| S484 | MDDTLsPVGVT | HPRD | |
| S395 | VSPGAsKTSSR | HPRD | |
| S501 | VSPGAsKTSSR | HPRD | |
| S157 | ANQVLsLPCPN | PhosphoSitePlus; HPRD | |
| S301 | STGLCsPDLVN | HPRD | |
| S397 | LLSSVsPGASK | HPRD | |
| S405 | RAHGLsLIPST | GSK_group | RegPhos |
| S174 | PPVPGsSAPNS | HPRD | |
| S156 | ANQVLsLPCPN | HPRD | |
| S32 | TLCLFsRSSSA | HPRD | |
| S504 | LLSSVsPGASK | PhosphoSitePlus | |
| S159 | PPVPGsSAPNS | HPRD | |
| S414 | STGLCsPDLVN | PhosphoSitePlus; phosphoELM; SysPTM | |
| S408 | STGLCsPDLVN | HPRD | |
| S486 | VSPGAsKTSSR | HPRD | |
| S384 | MDDTLsPVGVT | HPRD | |
| S502 | DPLLSsVSPGA | PhosphoSitePlus | |
| S141 | ANQVLsLPCPN | HPRD | |
| S374 | RAHGLsLIPST | GSK3B | HPRD |
| S383 | STGLCsPDLVN | HPRD | |
| S179 | SSAPNsPMAML | HPRD | |
| S405 | RAHGLsLIPST | GSK3B | RegPhos |
| S155 | SSAPNsPMAML | HPRD | |
| S73 | SSAPNsPMAML | HPRD | |
| Dephosphorylation site |
| MITF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377880 | R270L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000377880 | N323T | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| MITF_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MITF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | MITF_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | MITF_HUMAN | kinase -> substrate | RegPhos |
| KS6A1_HUMAN | MITF_HUMAN | kinase -> substrate | NetPath |
| MK01_HUMAN | MITF_HUMAN | kinase -> substrate | NetPath |
| FAK1_HUMAN | MITF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | MITF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MITF_HUMAN | BCL2_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | SUIS_HUMAN | TF -> target gene | TRANSFAC |
| SOX10_HUMAN | MITF_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | TYRP2_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | U627C_HUMAN | TF -> target gene | TRANSFAC |
| LEF1_HUMAN | MITF_HUMAN | TF -> target gene | TRANSFAC |
| CREB1_HUMAN | MITF_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | TYRO_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | TYRP1_HUMAN | TF -> target gene | TRANSFAC |
| PAX3_HUMAN | MITF_HUMAN | TF -> target gene | TRANSFAC |
| MITF_HUMAN | MAR1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa04380 | Osteoclast differentiation |
| hsa04916 | Melanogenesis |
| hsa05218 | Melanoma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0030316 | osteoclast differentiation | IEA | biological_process |
| GO:0010468 | regulation of gene expression | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0045165 | cell fate commitment | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0006461 | protein complex assembly | IDA | biological_process |
| GO:0043473 | pigmentation | IEA | biological_process |
| GO:0001077 | RNA polymerase II core promoter proximal region se | IDA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0045670 | regulation of osteoclast differentiation | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0030318 | melanocyte differentiation | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0046849 | bone remodeling | IEA | biological_process |
| GO:0042981 | regulation of apoptotic process | IEA | biological_process |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0043010 | camera-type eye development | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0030318 | melanocyte differentiation | NAS | biological_process |
| GO:0043234 | protein complex | IDA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |